Complement and Its Receptors: New Insights into Human Disease

Complement: a key system for immune surveillance and homeostasis

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Evolving concepts of rheumatoid arthritis

Firestein, G. S. (2003) · Nature · doi:10.1038/nature01661 · Cited by 3,601 · see citing works

The Classical Complement Cascade Mediates CNS Synapse Elimination

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The Instructive Role of Innate Immunity in the Acquired Immune Response

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C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity

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Generation of C5a in the absence of C3: a new complement activation pathway

Huber-Lang, M. S., Sarma, J. V., Zetoune, F. S., Rittirsch, D., Neff, T. A., McGuire, S. R., Lambris, J. D., Warner, R. L., Flierl, M. A., Hoesel, L. M., et al. (2006) · Nature Medicine · doi:10.1038/nm1419 · Cited by 976 · see citing works

MOLECULAR ORGANIZATION AND FUNCTION OF THE COMPLEMENT SYSTEM

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Discovery and Development of the Complement Inhibitor Eculizumab for the Treatment of Paroxysmal Nocturnal Hemoglobinuria

Rother, R. P., Rollins, S. A., Mojcik, C. F., Brodsky, R. A., & Bell, L. (2007) · Nature Biotechnology · doi:10.1038/nbt1344 · Cited by 778 · see citing works

Modulation of the antitumor immune response by complement

Markiewski, M. M., DeAngelis, R. A., Benencia, F., Ricklin-Lichtsteiner, S. K., Koutoulaki, A., Gerard, C. J., Coukos, G., & Lambris, J. D. (2008) · Nature Immunology · doi:10.1038/ni.1655 · Cited by 770 · see citing works

Molecular Intercommunication between the Complement and Coagulation Systems

Amara, U., Flierl, M. A., Rittirsch, D., Klos, A., Chen, H., Acker, B., Brückner, U. B., Nilsson, B., Gebhard, F. T., Lambris, J. D., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903678 · Cited by 719 · see citing works

Complement and coagulation: strangers or partners in crime?

Markiewski, M., Nilsson, B., Ekdahl, K., Mollnes, T., & Lambris, J. D. (2007) · Trends in immunology · doi:10.1016/j.it.2007.02.006 · Cited by 664 · see citing works

Drusen complement components C3a and C5a promote choroidal neovascularization

Nozaki, M., Raisler, B. J., Sakurai, E., Sarma, J. V., Barnum, S. R., Lambris, J. D., Chen, Y., Zhang, K., Ambati, B. K., Baffi, J. Z., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408835103 · Cited by 650 · see citing works

Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells

Phan, T. G., Grigorova, I., Okada, T., & Cyster, J. G. (2007) · Nature Immunology · doi:10.1038/ni1494 · Cited by 644 · see citing works

Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts

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CRIg: A Macrophage Complement Receptor Required for Phagocytosis of Circulating Pathogens

Helmy, K. Y., Katschke, K. J., Gorgani, N. N., Kljavin, N. M., Elliott, J. M., Diehl, L. J., Scales, S. J., Ghilardi, N., & Campagne, M. V. L. (2006) · Cell · doi:10.1016/j.cell.2005.12.039 · Cited by 629 · see citing works

THE ROLE OF COMPLEMENT AND COMPLEMENT RECEPTORS IN INDUCTION AND REGULATION OF IMMUNITY

Carroll, M. C. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.545 · Cited by 602 · see citing works

Aquaporin 4 and neuromyelitis optica

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Structure and biology of complement protein C3, a connecting link between innate and acquired immunity

Sahu, A., & Lambris, J. D. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1800103.x · Cited by 527 · see citing works

Genetic insights into common pathways and complex relationships among immune-mediated diseases

Parkes, M., Cortés, A., van Heel, D. A., & Brown, M. A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3502 · Cited by 522 · see citing works

Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction

Girardi, G., Yarilin, D. A., Thurman, J. M., Holers, V. M., & Salmon, J. E. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061022 · Cited by 507 · see citing works

Control of the Complement System

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A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration

Hughes, A. E., Orr, N., Esfandiary, H., Diaz-Torres, M., Goodship, T., & Chakravarthy, U. (2006) · Nature Genetics · doi:10.1038/ng1890 · Cited by 467 · see citing works

The Regulators of Complement Activation (RCA) Gene Cluster

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The proinflammatory mediators C3a and C5a are essential for liver regeneration

Strey, C. W., Markiewski, M., Mastellos, D., Tudoran, R., Spruce, L. A., Greenbaum, L. E., & Lambris, J. D. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030374 · Cited by 436 · see citing works

Eculizumab in AQP4-IgG-positive relapsing neuromyelitis optica spectrum disorders: an open-label pilot study

Pittock, S. J., Lennon, V. A., McKeon, A. B., Mandrekar, J. N., Weinshenker, B. G., Lucchinetti, C. F., O’Toole, O., & Wingerchuk, D. M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70076-0 · Cited by 392 · see citing works

A Critical Role for Complement in Maintenance of Self-Tolerance

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Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo

Zhang, X., Kimura, Y., Fang, C., Zhou, L., Sfyroera, G., Lambris, J. D., Wetsel, R. A., Miwa, T., & Song, W. (2007) · Blood · doi:10.1182/blood-2006-12-063636 · Cited by 373 · see citing works

C3 glomerulopathy: a new classification

Fakhouri, F., Frémeaux‐Bacchi, V., Noël, L., Cook, H. T., & Pickering, M. C. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.85 · Cited by 361 · see citing works

Complement fraction 3 binding on erythrocytes as additional mechanism of disease in paroxysmal nocturnal hemoglobinuria patients treated by eculizumab

Risitano, A. M., Notaro, R., Marando, L., Serio, B., Ranaldi, D., Seneca, E., Ricci, P., Alfinito, F., Camera, A., Gianfaldoni, G., et al. (2009) · Blood · doi:10.1182/blood-2008-11-189944 · Cited by 361 · see citing works

A role for the C3a anaphylatoxin receptor in the effector phase of asthma

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Extrahepatic complement biosynthesis: where, when and why?

Morgan, B. P., & Gasque, P. (1997) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1997.d01-890.x · Cited by 351 · see citing works

Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis

Gale, D. P., de Jorge, E. G., Cook, H. T., Martínez‐Barricarte, R., Hadjisavvas, A., McLean, A. G., Pusey, C. D., Pierides, A., Kyriacou, K. C., Athanasiou, Y., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60670-8 · Cited by 326 · see citing works

Complement driven by conformational changes

Gros, P., Milder, F. J., & Janssen, B. J. C. (2007) · Nature reviews. Immunology · doi:10.1038/nri2231 · Cited by 324 · see citing works

Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3+ regulatory T cells

Strainic, M. G., Shevach, E. M., An, F., Lin, F., & Medof, M. E. (2012) · Nature Immunology · doi:10.1038/ni.2499 · Cited by 302 · see citing works

C1q, Autoimmunity and Apoptosis

Botto, M. (2002) · Immunobiology · doi:10.1078/0171-2985-00141 · Cited by 291 · see citing works

Dimerization of complement factor H-related proteins modulates complement activation in vivo

de Jorge, E. G., Caesar, J. J. E., Malik, T. H., Patel, M., Colledge, M., Johnson, S., Hakobyan, S., Morgan, B. P., Harris, C. L., Pickering, M. C., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219260110 · Cited by 290 · see citing works

Mutations in Complement Regulatory Proteins Predispose to Preeclampsia: A Genetic Analysis of the PROMISSE Cohort

Salmon, J. E., Heuser, C. C., Triebwasser, M. P., Liszewski, M. K., Kavanagh, D., Roumenina, L. T., Branch, D. W., Goodship, T. H. J., Frémeaux‐Bacchi, V., & Atkinson, J. P. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001013 · Cited by 285 · see citing works

Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains

Pickering, M. C., de Jorge, E. G., Martínez‐Barricarte, R., Recalde, S., García‐Layana, A., Rose, K. L., Moss, J., Walport, M. J., Cook, H. T., de Córdoba, S. R., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070301 · Cited by 278 · see citing works

C5a Negatively Regulates Toll-like Receptor 4-Induced Immune Responses

Hawlisch, H., Belkaid, Y., Bälder, R., Hildeman, D. A., Gerard, C. J., & Köhl, J. (2005) · Immunity · doi:10.1016/j.immuni.2005.02.006 · Cited by 277 · see citing works

Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer’s Disease

Fonseca, M. I., Ager, R. R., Chu, S.-H., Yazan, O., Sanderson, S. D., LaFerla, F. M., Taylor, S. M., Woodruff, T. M., & Tenner, A. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901005 · Cited by 268 · see citing works

Complement in human diseases: Lessons from complement deficiencies

Botto, M., Kirschfink, M., Macor, P., Pickering, M. C., Würzner, R., & Tedesco, F. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.04.029 · Cited by 264 · see citing works

Inhibition of Mannose-Binding Lectin Reduces Postischemic Myocardial Reperfusion Injury

Jordan, J. E., Montalto, M. C., & Stahl, G. L. (2001) · Circulation · doi:10.1161/hc3601.095578 · Cited by 263 · see citing works

Factor H family proteins and human diseases

Józsi, M., & Zipfel, P. F. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.04.008 · Cited by 254 · see citing works

Factor H family proteins: on complement, microbes and human diseases

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C1 Inhibitor and Hereditary Angioneurotic Edema

Davis, A. E. (1988) · Annual Review of Immunology · doi:10.1146/annurev.iy.06.040188.003115 · Cited by 247 · see citing works

Complement receptors and phagocytosis

Brown, E. J. (1991) · Current Opinion in Immunology · doi:10.1016/0952-7915(91)90081-b · Cited by 243 · see citing works

The Role of Complement in B Cell Activation and Tolerance

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Structural basis for engagement by complement factor H of C3b on a self surface

Morgan, H. P., Schmidt, C. Q., Guariento, M., Blaum, B. S., Gillespie, D., Herbert, A. P., Kavanagh, D., Mertens, H. D. T., Svergun, D. I., Johansson, C. M., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2018 · Cited by 239 · see citing works

Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk

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Microbial Hijacking of Complement–Toll-Like Receptor Crosstalk

Wang, M., Krauss, J. L., Domon, H., Hosur, K. B., Liang, S., Magotti, P., Triantafilou, M., Triantafilou, K., Lambris, J. D., & Hajishengallis, G. (2010) · Science Signaling · doi:10.1126/scisignal.2000697 · Cited by 229 · see citing works

The Amplification Loop of the Complement Pathways

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C1 Inhibitor And Hereditary Angioneurotic Edema

Davis, A. E. (1988) · Annual Review of Immunology · doi:10.1146/annurev.immunol.6.1.595 · Cited by 218 · see citing works

Structure, function and cellular expression of complement anaphylatoxin receptors

Wetsel, R. A. (1995) · Current Opinion in Immunology · doi:10.1016/0952-7915(95)80028-x · Cited by 211 · see citing works

The CD46-Jagged1 interaction is critical for human TH1 immunity

Friec, G. L., Sheppard, D., Whiteman, P., Karsten, C. M., Shamoun, S. A.-T., Laing, A. G., Bugeon, L., Dallman, M. J., Melchionna, T., Chillakuri, C., et al. (2012) · Nature Immunology · doi:10.1038/ni.2454 · Cited by 204 · see citing works

Complement inhibitor C4b-binding protein—friend or foe in the innate immune system?

Blom, A. M., Villoutreix, B. O., & Dahlbäck, B. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2003.12.002 · Cited by 202 · see citing works

C3 glomerulopathy–associated CFHR1 mutation alters FHR oligomerization and complement regulation

Tortajada, A., Yébenes, H., Abarrategui-Garrido, C., Anter, J., García-Fernández, J., Martínez‐Barricarte, R., Alba‐Domínguez, M., Malik, T. H., Bedoya, R., Pérez, R. C., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68280 · Cited by 197 · see citing works

Complement activation on platelet-leukocyte complexes and microparticles in enterohemorrhagic Escherichia coli–induced hemolytic uremic syndrome

Ståhl, A.-L., Sartz, L., & Karpman, D. (2011) · Blood · doi:10.1182/blood-2010-09-309161 · Cited by 197 · see citing works

Identification of immunoglobulins and complement in rheumatoid articular collagenous tissues

Cooke, T. D. V., Hurd, E. R., Jasin, H. E., Bienenstock, J., & Ziff, M. (1975) · Arthritis & Rheumatism · doi:10.1002/art.1780180603 · Cited by 194 · see citing works

A protective role for innate immunity in systemic lupus erythematosus

Carroll, M. (2004) · Nature reviews. Immunology · doi:10.1038/nri1456 · Cited by 187 · see citing works

Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis

Silasi‐Mansat, R., Zhu, H., Popescu, N. I., Peer, G. T., Sfyroera, G., Magotti, P., Ivanciu, L., Lupu, C., Mollnes, T. E., Taylor, F. B., et al. (2010) · Blood · doi:10.1182/blood-2010-02-269746 · Cited by 186 · see citing works

Translational Mini-Review Series on Complement Factor H: Renal diseases associated with complement factor H: novel insights from humans and animals

Pickering, M. C., & Cook, H. T. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03574.x · Cited by 185 · see citing works

Carboxypeptidase N: a pleiotropic regulator of inflammation

Matthews, K. R. W., Mueller‐Ortiz, S. L., & Wetsel, R. A. (2003) · Molecular Immunology · doi:10.1016/j.molimm.2003.10.002 · Cited by 185 · see citing works

Oxidation and age-related macular degeneration: insights from molecular biology

Khandhadia, S., & Lotery, A. J. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s146239941000164x · Cited by 180 · see citing works

Contribution of the innate immune system to autoimmune myocarditis: a role for complement

Kaya, Z., Afanasyeva, M., Wang, Y., Dohmen, K. M., Schlichting, J., Tretter, T., Fairweather, D., Holers, V. M., & Rose, N. R. (2001) · Nature Immunology · doi:10.1038/90686 · Cited by 175 · see citing works

BAFF and selection of autoreactive B cells

Liu, Z., & Davidson, A. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.06.004 · Cited by 171 · see citing works

Initiation of complement activation

Lachmann, P. J., & Hughes-Jones, N. C. (1984) · Springer Seminars in Immunopathology · doi:10.1007/bf01893018 · Cited by 164 · see citing works

The immunoglobulin, IgG Fc receptor and complement triangle in autoimmune diseases

Karsten, C. M., & Köhl, J. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.07.015 · Cited by 159 · see citing works

Immune complex processing in patients with systemic lupus erythematosus. In vivo imaging and clearance studies.

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Local production of complement proteins in rheumatoid arthritis synovium

Neumann, E., Barnum, S. R., Tarner, I. H., Echols, J., Fleck, M., Judex, M., Kullmann, F., Mountz, J. D., Schölmerich, J., Gay, S., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10183 · Cited by 155 · see citing works

Alternative Complement Pathway Activation Is Essential for Inflammation and Joint Destruction in the Passive Transfer Model of Collagen-Induced Arthritis

Banda, N. K., Thurman, J. M., Kraus, D., Wood, A., Carroll, M. C., Arend, W. P., & Holers, V. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1904 · Cited by 153 · see citing works

Human Complement Receptor Type 1/CD35 Is an Epstein-Barr Virus Receptor

Ogembo, J. G., Kannan, L., Ghiran, I. C., Nicholson-Weller, A., Finberg, R. W., Tsokos, G. C., & Fingeroth, J. D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.023 · Cited by 153 · see citing works

The tick-over theory revisited: Is C3 a contact-activated protein?

Nilsson, B., & Ekdahl, K. N. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.07.008 · Cited by 149 · see citing works

Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome

Fang, C. J., Frémeaux‐Bacchi, V., Liszewski, M. K., Pianetti, G., Noris, M., Goodship, T. H. J., & Atkinson, J. P. (2007) · Blood · doi:10.1182/blood-2007-04-084533 · Cited by 148 · see citing works

Ficolins: Novel pattern recognition molecules of the innate immune response

Runza, V., Schwaeble, W., & Männel, D. N. (2007) · Immunobiology · doi:10.1016/j.imbio.2007.10.009 · Cited by 142 · see citing works

Is complement good or bad for cancer patients? A new perspective on an old dilemma

Markiewski, M. M., & Lambris, J. D. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.04.002 · Cited by 139 · see citing works

Role of C3a Receptors, C5a Receptors, and Complement Protein C6 Deficiency in Collagen Antibody-Induced Arthritis in Mice

Banda, N. K., Hyatt, S., Antonioli, A. H., White, J. T., Glogowska, M. J., Takahashi, K., Merkel, T. J., Stahl, G. L., Mueller‐Ortiz, S. L., Wetsel, R. A., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102310 · Cited by 137 · see citing works

A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice

He, S., Atkinson, C., Qiao, F., Cianflone, K., Chen, X., & Tomlinson, S. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38289 · Cited by 134 · see citing works

Human complement control and complement evasion by pathogenic microbes – Tipping the balance

Zipfel, P. F., Hallström, T., & Riesbeck, K. (2013) · Molecular Immunology · doi:10.1016/j.molimm.2013.05.222 · Cited by 134 · see citing works

Cutting Edge: Localization of the Host Recognition Functions of Complement Factor H at the Carboxyl-Terminal: Implications for Hemolytic Uremic Syndrome

Pangburn, M. K. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.4702 · Cited by 133 · see citing works

Factor I is required for the development of membranoproliferative glomerulonephritis in factor H–deficient mice

Rose, K. L., Paixão-Cavalcante, D., Fish, J., Manderson, A. P., Malik, T. H., Bygrave, A. E., Lin, T., Sacks, S. H., Walport, M. J., Cook, H. T., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32525 · Cited by 132 · see citing works

C3a Is Required for the Production of CXC Chemokines by Tubular Epithelial Cells after Renal Ishemia/Reperfusion

Thurman, J. M., Lenderink, A. M., Royer, P. A., Coleman, K. E., Zhou, J., Lambris, J. D., Nemenoff, R. A., Quigg, R. J., & Holers, V. M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1819 · Cited by 131 · see citing works

Mannan-binding lectin?a soluble pattern recognition molecule

Gadjeva, M. G. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.03.015 · Cited by 131 · see citing works

The role of complement system in ocular diseases including uveitis and macular degeneration

Jha, P., Bora, P. S., & Bora, N. S. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.06.145 · Cited by 130 · see citing works

Endothelial Oxidative Stress Activates the Lectin Complement Pathway

Collard, C. D., Montalto, M. C., Reenstra, W. R., Buras, J. A., & Stahl, G. L. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61779-8 · Cited by 129 · see citing works

A Hybrid CFHR3-1 Gene Causes Familial C3 Glomerulopathy

Malik, T. H., Lavin, P., de Jorge, E. G., Vernon, K. A., Rose, K. L., Patel, M., de Leeuw, M. A., Neary, J. J., Conlon, P. J., Winn, M. P., et al. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012020166 · Cited by 129 · see citing works

Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: Role of factor B and factor H

Bora, N. S., Kaliappan, S., Jha, P., Xu, Q., Sohn, J.-H., Dhaulakhandi, D. B., Kaplan, H. J., & Bora, P. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1872 · Cited by 124 · see citing works

Crossroads of coagulation and innate immunity: the case of deep vein thrombosis

Schulz, C., Engelmann, B., & Maßberg, S. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12261 · Cited by 122 · see citing works

Effects of complement factor D deficiency on the renal disease of MRL/lpr mice

Elliott, M. K., Jarmi, T., Ruiz, P., Xu, Y., Holers, V. M., & Gilkeson, G. S. (2003) · Kidney International · doi:10.1111/j.1523-1755.2004.00371.x · Cited by 118 · see citing works

A Non Membrane-Targeted Human Soluble CD59 Attenuates Choroidal Neovascularization in a Model of Age Related Macular Degeneration

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Progress and Trends in Complement Therapeutics

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Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging

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Innate Autoimmunity

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Detection of complement activation using monoclonal antibodies against C3d

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Administration of a Soluble Recombinant Complement C3 Inhibitor Protects Against Renal Disease in MRL/lpr Mice

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The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization

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Complement C2 Receptor Inhibitor Trispanning: A Novel Human Complement Inhibitory Receptor

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Clinical Manifestations of Paroxysmal Nocturnal Hemoglobinuria: Present State and Future Problems

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Macrophage-Derived Complement Component C4 Can Restore Humoral Immunity in C4-Deficient Mice

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NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

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CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria

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A high-throughput, bead-based, antigen-specific assay to assess the ability of antibodies to induce complement activation

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Receptor-Mediated NETosis on Neutrophils

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Compendium of current complement therapeutics

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Thrombotic microangiopathy following systemic AAV administration is dependent on anti-capsid antibodies

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Complement activation and endothelial perturbation parallel COVID-19 severity and activity

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Why do we study animal toxins?

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Complement in the Initiation and Evolution of Rheumatoid Arthritis

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Myasthenia gravis: the changing treatment landscape in the era of molecular therapies

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Role of the complement system in the tumor microenvironment

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Membrane assembly of aquaporin-4 autoantibodies regulates classical complement activation in neuromyelitis optica.

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Complement in therapy and disease

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Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes

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Complement Inhibitors in Clinical Trials for Glomerular Diseases

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Challenges Posed by Immune Responses to AAV Vectors: Addressing Root Causes

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Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper

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Properdin: a tightly regulated critical inflammatory modulator

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Analysis of the Complement System in the Clinical Immunology Laboratory

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Complement regulator CD46: genetic variants and disease associations

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Fungal glycans and the innate immune recognition

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The complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain

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Regulation of complement and modulation of its activity in monoclonal antibody therapy of cancer

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Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases

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Overcoming Nanoparticle-Mediated Complement Activation by Surface PEG Pairing

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Complement analysis 2016: Clinical indications, laboratory diagnostics and quality control

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Protein Termini and Their Modifications Revealed by Positional Proteomics

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Complement C5a receptor is the key initiator of neutrophil adhesion igniting immune complex–induced arthritis

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Engineering nanoparticles to overcome immunological barriers for enhanced drug delivery

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The impact of protein corona on the biological behavior of targeting nanomedicines

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Complement Evasion: An Effective Strategy That Parasites Utilize to Survive in the Host

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Treatment with the Pseudomonas aeruginosa Glycoside Hydrolase PslG Combats Wound Infection by Improving Antibiotic Efficacy and Host Innate Immune Activity

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The multifaceted impact of complement on atherosclerosis

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Developments in anti-complement therapy; from disease to clinical trial

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Properdin: A multifaceted molecule involved in inflammation and diseases

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Targeting the Sugary Armor of Klebsiella Species

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Serum Complement C3 and C4 and COVID-19 Severity and Mortality: A Systematic Review and Meta-Analysis With Meta-Regression

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From risk to chronicity: evolution of autoreactive B cell and antibody responses in rheumatoid arthritis

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Cell-autonomous regulation of complement C3 by factor H limits macrophage efferocytosis and exacerbates atherosclerosis

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The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1

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Marginal zone B cells acquire dendritic cell functions by trogocytosis

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Effect of Lipid Nanoparticle Physico-Chemical Properties and Composition on Their Interaction with the Immune System

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Novel aspects of atypical haemolytic uraemic syndrome and the role of eculizumab

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The nasal mucosal late allergic reaction to grass pollen involves type 2 inflammation (IL-5 and IL-13), the inflammasome (IL-1β), and complement

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Bacteriophage and the Innate Immune System: Access and Signaling

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Unintended effects of drug carriers: Big issues of small particles

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Complement activation by drug carriers and particulate pharmaceuticals: Principles, challenges and opportunities

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Signaling pathways regulating neuron–glia interaction and their implications in Alzheimer's disease

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C-Reactive Protein and Its Structural Isoforms: An Evolutionary Conserved Marker and Central Player in Inflammatory Diseases and Beyond

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Nanomedicine safety in preclinical and clinical development: focus on idiosyncratic injection/infusion reactions

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Regulation of the complement system and immunological tolerance in pregnancy

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The Complement System in Lupus Nephritis

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Complement Receptors in Myeloid Cell Adhesion and Phagocytosis

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The Interplay Between Blood Proteins, Complement, and Macrophages on Nanomedicine Performance and Responses

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Complement Activation in the Vitreous of Patients With Proliferative Diabetic Retinopathy

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Expanding horizons in complement drug discovery: challenges and emerging strategies

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Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment

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Complement Activation Is a Prominent Feature of MOGAD

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The complex functioning of the complement system in xenotransplantation

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Outstanding questions in transplantation: B cells, alloantibodies, and humoral rejection

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Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody

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ARGX-117, a therapeutic complement inhibiting antibody targeting C2

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The relationship of circulating proteins in early pregnancy with preterm birth

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Activation of Human Complement System by Dextran-Coated Iron Oxide Nanoparticles Is Not Affected by Dextran/Fe Ratio, Hydroxyl Modifications, and Crosslinking

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Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis

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Complement System: An Immunotherapy Target in Colorectal Cancer

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Activation of C3a receptor is required in cigarette smoke-mediated emphysema

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Mechanisms of SARS-CoV-2-induced lung vascular disease: potential role of complement

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A quantitative lateral flow assay to detect complement activation in blood

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Understanding the bidirectional interactions between two-dimensional materials, microorganisms, and the immune system

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The hijackers guide to escaping complement: Lessons learned from pathogens

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Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer’s disease

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Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease

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Acquired decrease of the C3b/C4b receptor (CR1, CD35) and increased C4d deposits on erythrocytes from ICU COVID-19 patients

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The complement system in health and disease

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The Complement System

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Complement activation and regulation in rheumatic disease

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Complement as New Immunotherapy Target

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Complement regulation: physiology and disease relevance

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