C1q: A fresh look upon an old molecule

Complement: a key system for immune surveillance and homeostasis

Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654 · cited 1×

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Hong, S., Beja-Glasser, V. F., Nfonoyim, B. M., Frouin, A., Li, S., Ramakrishnan, S., Merry, K. M., Shi, Q., Rosenthal, A., Barres, B. A., et al. (2016) · Science · doi:10.1126/science.aad8373 · Cited by 3,343 · cited 2×

The Classical Complement Cascade Mediates CNS Synapse Elimination

Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313

Schizophrenia risk from complex variation of complement component 4

Sekar, A., Bialas, A. R., de Rivera, H., Davis, A., Hammond, T. R., Kamitaki, N., Tooley, K., Presumey, J., Baum, M., Van Doren, V., et al. (2016) · Nature · doi:10.1038/nature16549 · Cited by 2,394

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

Baechler, E. C., Batliwalla, F., Karypis, G., Gaffney, P. M., Ortmann, W. A., Espe, K. J., Shark, K. B., Grande, W. J., Hughes, K. M. H., Kapur, V., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337679100 · Cited by 2,246

Siglecs and their roles in the immune system

Crocker, P. R., Paulson, J. C., & Varki, A. P. (2007) · Nature reviews. Immunology · doi:10.1038/nri2056 · Cited by 2,032

Complement System Part I – Molecular Mechanisms of Activation and Regulation

Merle, N. S., Church, S. E., Fremeaux-Bacchi, V., & Roumenina, L. T. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00262 · Cited by 1,620

Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte

Gardai, S. J., McPhillips, K. A., Frasch, S. C., Janssen, W. J., Starefeldt, A., Murphy-Ullrich, J. E., Bratton, D. L., Oldenborg, P.-A., Michalak, M., & Henson, P. M. (2005) · Cell · doi:10.1016/j.cell.2005.08.032 · Cited by 1,473

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

Botto, M., Dell' Agnola, C., Bygrave, A. E., Thompson, E. M., Cook, H. T., Petry, F., Loos, M., Pandolfi, P. P., & Walport, M. J. (1998) · Nature Genetics · doi:10.1038/ng0598-56 · Cited by 1,434

The Uterine Spiral Arteries In Human Pregnancy: Facts and Controversies

Pijnenborg, R., Vercruysse, L., & HANSSENS, M. C. A. J. A. (2006) · Placenta · doi:10.1016/j.placenta.2005.12.006 · Cited by 1,229

C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells

Ogden, C. A., deCathelineau, A. M., Hoffmann, P. R., Bratton, D. L., Ghebrehiwet, B., Fadok, V. A., & Henson, P. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.781 · Cited by 1,148

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

Stephan, A. H., Barres, B. A., & Stevens, B. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113810 · Cited by 1,113

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

Wyss-Coray, T., & Rogers, J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006346 · Cited by 975

Advances in skin grafting and treatment of cutaneous wounds

Sun, B. K., Siprashvili, Z., & Khavari, P. A. (2014) · Science · doi:10.1126/science.1253836 · Cited by 972

Modulation of the antitumor immune response by complement

Markiewski, M. M., DeAngelis, R. A., Benencia, F., Ricklin-Lichtsteiner, S. K., Koutoulaki, A., Gerard, C. J., Coukos, G., & Lambris, J. D. (2008) · Nature Immunology · doi:10.1038/ni.1655 · Cited by 770

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

Lui, H., Zhang, J., Makinson, S. R., Cahill, M. K., Kelley, K. W., Huang, H.-Y., Shang, Y., Oldham, M. C., Martens, L. H., Gao, F., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.001 · Cited by 729

INTERACTION OF AGGREGATED γ-GLOBULIN WITH B LYMPHOCYTES

Dickler, H. B., & Kunkel, H. G. (1972) · The Journal of Experimental Medicine · doi:10.1084/jem.136.1.191 · Cited by 673

A complement–microglial axis drives synapse loss during virus-induced memory impairment

Vasek, M. J., Garber, C., Dorsey, D., Durrant, D. M., Bollman, B., Soung, A., Yu, J., Perez-Torres, C., Frouin, A., Wilton, D. K., et al. (2016) · Nature · doi:10.1038/nature18283 · Cited by 671

C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited

Korb, L. C., & Ahearn, J. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.10.4525 · Cited by 659

The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor

Shapiro, L. S., & Scherer, P. E. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70133-2 · Cited by 652

The Role of Complement in the Development of Systemic Lupus Erythematosus

Manderson, A. P., Botto, M., & Walport, M. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104549 · Cited by 538

Role of Surfactant Proteins A, D, and C1q in the Clearance of Apoptotic Cells In Vivo and In Vitro: Calreticulin and CD91 as a Common Collectin Receptor Complex

Vandivier, R. W., Ogden, C. A., Fadok, V. A., Hoffmann, P. R., Brown, K. K., Botto, M., Walport, M. J., Fisher, J. H., Henson, P. M., & Greene, K. E. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3978 · Cited by 517

Complement in the brain

Veerhuis, R., Nielsen, H. M., & Tenner, A. J. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.04.003 · Cited by 436

CHROMATOGRAPHIC RESOLUTION OF THE FIRST COMPONENT OF HUMAN COMPLEMENT INTO THREE ACTIVITIES

Lepow, I. H., Naff, G. B., Todd, E. W., Pensky, J., & Hinz, C. F. (1963) · The Journal of Experimental Medicine · doi:10.1084/jem.117.6.983 · Cited by 378

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline

Shi, Q., Colodner, K. J., Matousek, S. B., Merry, K., Hong, S., Kenison, J. E., Frost, J. L., Le, K. X., Li, S., Dodart, J.-C., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1698-15.2015 · Cited by 368

Complement activation and inhibition: a delicate balance

Sjöberg, A. P., Trouw, L. A., & Blom, A. M. (2009) · Trends in Immunology · doi:10.1016/j.it.2008.11.003 · Cited by 364

The Crystal Structure of the Globular Head of Complement Protein C1q Provides a Basis for Its Versatile Recognition Properties

Gaboriaud, C., Juanhuix, J., Gruez, A., Lacroix, M., Darnault, C., Pignol, D., Verger, D., Fontecilla-Camps, J. C., & Arlaud, G. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307764200 · Cited by 362

Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q.

Ghebrehiwet, B., Lim, B. L., Peerschke, E. I. B., Willis, A. C., & Reid, K. B. M. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.6.1809 · Cited by 347

Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain

Fonseca, M. I., Chu, S.-H., Hernandez, M. X., Fang, M. J., Modarresi, L., Selvan, P., MacGregor, G. R., & Tenner, A. J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0814-9 · Cited by 337

Subunit composition and structure of subcomponent C1q of the first component of human complement

Reid, K. B. M., & Porter, R. (1976) · Biochemical Journal · doi:10.1042/bj1550019 · Cited by 329

CR3: a general purpose adhesion-recognition receptor essential for innate immunity

Ehlers, M. R. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)00299-9 · Cited by 323

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

Naito, A. T., Sumida, T., Nomura, S., Liu, M.-L., Higo, T., Nakagawa, A., Okada, K., Sakai, T., Hashimoto, A., Hara, Y., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.047 · Cited by 320

C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation

Bulla, R., Tripodo, C., Rami, D., Ling, G. S., Agostinis, C., Guarnotta, C., Zorzet, S., Durigutto, P., Botto, M., & Tedesco, F. (2016) · Nature Communications · doi:10.1038/ncomms10346 · Cited by 301

Complement, C1q, and C1q-Related Molecules Regulate Macrophage Polarization

Bohlson, S. S., Oâ€TMConner, S. D., Hulsebus, H. J., Ho, M.-M., & Fraser, D. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00402 · Cited by 299

Human Pulmonary Surfactant Protein (SP-A), a Protein Structurally Homologous to C1q, Can Enhance FcR- and CR1-mediated Phagocytosis

Tenner, A. J., Robinson, S. L., Borchelt, J. D., & Wright, J. R. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)80088-6 · Cited by 294

The inhibitory collagen receptor LAIR-1 (CD305)

Meyaard, L. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0907609 · Cited by 290

The Globular Heads of C1q Specifically Recognize Surface Blebs of Apoptotic Vascular Endothelial Cells

Navratil, J. S., Watkins, S. C., Wisnieski, J. J., & Ahearn, J. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.5.3231 · Cited by 262

Structure–function relationships of complement receptor type 1

Krych‐Goldberg, M., & Atkinson, J. P. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1800110.x · Cited by 259

Molecular and Cellular Characterization of the Membrane Attack Complex, C5b-9, in Alzheimer’s Disease

Webster, S. D., Lue, L., Brachova, L., Tenner, A. J., McGeer, P. L., Terai, K., Walker, D. G., Bradt, B. M., Cooper, N. R., & Rogers, J. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00042-0 · Cited by 258

Complement Receptor Type 1 (CR1, CD35) Is a Receptor for C1q

Klickstein, L. B., Barbashov, S. F., Liu, T., Jack, R. M., & Nicholson-Weller, A. (1997) · Immunity · doi:10.1016/s1074-7613(00)80356-8 · Cited by 257

Complement Protein C1q Directs Macrophage Polarization and Limits Inflammasome Activity during the Uptake of Apoptotic Cells

Benoit, M. E., Clarke, E. V., Morgado, P., Fraser, D. A., & Tenner, A. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103760 · Cited by 253

RAGE in tissue homeostasis, repair and regeneration

Sorci, G., Riuzzi, F., Giambanco, I., & Donato, R. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.10.021 · Cited by 237

Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling

Li, Y., Cheng, Y., Huang, Y., Conti, M., Wilson, S. P., O’Donnell, J. M., & Zhang, H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5236-10.2011 · Cited by 234

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity

Ramirez‐Ortiz, Z. G., Pendergraft, W. F., Prasad, A., Byrne, M. H., Iram, T., Blanchette, C. J., Luster, A. D., Hacohen, N., Khoury, J. B. E., & Means, T. K. (2013) · Nature Immunology · doi:10.1038/ni.2670 · Cited by 227

Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q

Sellar, G., Blake, D. J., & Reid, K. B. M. (1991) · Biochemical Journal · doi:10.1042/bj2740481 · Cited by 211

Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions

Bohlson, S. S., Fraser, D. A., & Tenner, A. J. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.06.021 · Cited by 199

C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production

Fraser, D. A., Pisalyaput, K., & Tenner, A. J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06494.x · Cited by 196

Role of Complement Component C1q in the Onset of Preeclampsia in Mice

Singh, J. K., Ahmed, A., & Girardi, G. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.175919 · Cited by 189

The complement system in the pathophysiology of pregnancy

Girardi, G., Bulla, R., Salmon, J. E., & Tedesco, F. (2005) · Molecular Immunology · doi:10.1016/j.molimm.2005.06.017 · Cited by 184

Emerging and Novel Functions of Complement Protein C1q

Kouser, L., Madhukaran, S. P., Shastri, A., Saraon, A., Ferluga, J., Al-Mozaini, M., & Kishore, U. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00317 · Cited by 183

The physiological role of DC-SIGN: A tale of mice and men

García-Vallejo, J. J., & van Kooyk, Y. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.03.001 · Cited by 183

Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

Williams, P. A., Tribble, J. R., Pepper, K. W., Cross, S. D., Morgan, B. P., Morgan, J. E., John, S. W. M., & Howell, G. R. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0091-6 · Cited by 183

Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes

Iram, T., Ramirez‐Ortiz, Z. G., Byrne, M. H., Coleman, U. A., Kingery, N. D., Means, T. K., Frenkel, D., & Khoury, J. B. E. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3850-15.2016 · Cited by 183

C1q and HMGB1 reciprocally regulate human macrophage polarization

Son, M., Porat, A., He, M., Suurmond, J., Santiago‐Schwarz, F., Andersson, U., Coleman, T. R., Volpe, B. T., Tracey, K. J., Al‐Abed, Y., et al. (2016) · Blood · doi:10.1182/blood-2016-05-719757 · Cited by 182

C1q limits dendritic cell differentiation and activation by engaging LAIR-1

Son, M., Santiago‐Schwarz, F., Al‐Abed, Y., & Diamond, B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212753109 · Cited by 179

Modulation of FcR function by complement: subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages.

Bobak, D., Gaither, T., Frank, M. M., & Tenner, A. (1987) · Journal of Immunology · doi:10.4049/jimmunol.138.4.1150 · Cited by 171

An Alternative Role of C1q in Cell Migration and Tissue Remodeling: Contribution to Trophoblast Invasion and Placental Development

Agostinis, C., Bulla, R., Tripodo, C., Gismondi, A., Stabile, H., Bossi, F., Guarnotta, C., Garlanda, C., Seta, F. D., Spessotto, P., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903215 · Cited by 169

Stimulation of Neurogenesis and Synaptogenesis by Bilobalide and Quercetin via Common Final Pathway in Hippocampal Neurons

Tchantchou, F., Lacor, P. N., Cao, Z., Lao, L., Hou, Y., Cui, C., Klein, W. L., & Luo, Y. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1189 · Cited by 164

Complement Protein C1q-Mediated Neuroprotection Is Correlated with Regulation of Neuronal Gene and MicroRNA Expression

Benoit, M. E., & Tenner, A. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3932-10.2011 · Cited by 163

Mannose binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 Mr component of the Clq receptor

Tenner, A. J., Robinson, S. L., & Ezekowitz, R. A. B. (1995) · Immunity · doi:10.1016/1074-7613(95)90177-9 · Cited by 162

C1q as a unique player in angiogenesis with therapeutic implication in wound healing

Bossi, F., Tripodo, C., Rizzi, L., Bulla, R., Agostinis, C., Guarnotta, C., Munaut, C., Baldassarre, G., Papa, G., Zorzet, S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311968111 · Cited by 161

Circular-dichroism and electron-microscopy studies of human subcomponent C1q before and after limited proteolysis by pepsin

Brodsky-Doyle, B., Leonard, K., & Reid, K. B. M. (1976) · Biochemical Journal · doi:10.1042/bj1590279 · Cited by 159

C1q-induced LRP1B and GPR6 Proteins Expressed Early in Alzheimer Disease Mouse Models, Are Essential for the C1q-mediated Protection against Amyloid-β Neurotoxicity

Benoit, M. E., Hernandez, M. X., Dinh, M. L., Benavente, F., Vasquez, O., & Tenner, A. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.400168 · Cited by 155

C1q Deficiency Leads to the Defective Suppression of IFN-α in Response to Nucleoprotein Containing Immune Complexes

Santer, D. M., Hall, B. E., George, T. C., Tangsombatvisit, S., Liu, C. L., Arkwright, P. D., & Elkon, K. B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001731 · Cited by 151

Interaction of C1q with IgG1, C-reactive Protein and Pentraxin 3: Mutational Studies Using Recombinant Globular Head Modules of Human C1q A, B, and C Chains

Roumenina, L. T., Ruseva, M. M., Zlatarova, A. S., Ghai, R., Kolev, M. V., Olova, N. N., Gadjeva, M. G., Agrawal, A. C., Bottazzi, B., Mantovani, A., et al. (2006) · Biochemistry · doi:10.1021/bi052646f · Cited by 148

Murine CD93 (C1qRp) Contributes to the Removal of Apoptotic Cells In Vivo but Is Not Required for C1q-Mediated Enhancement of Phagocytosis

Norsworthy, P. J., Fossati‐Jimack, L., Cortés-Hernández, J., Taylor, P. R., Bygrave, A. E., Thompson, R. D., Nourshargh, S., Walport, M. J., & Botto, M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3406 · Cited by 146

SREC-I, a Type F Scavenger Receptor, Is an Endocytic Receptor for Calreticulin

Berwin, B. L., Delneste, Y., Lovingood, R. V., Post, S. R., & Pizzo, S. V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406202200 · Cited by 145

Reaction between the isolated globular sub-units of the complement component Clq and IgG-complexes

Hughes-Jones, N. C., & Gardner, B. (1979) · Molecular Immunology · doi:10.1016/0161-5890(79)90010-5 · Cited by 135

Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3-mediated removal by microglia

Linnartz, B., Kopatz, J., Tenner, A. J., & Neumann, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3830-11.2012 · Cited by 134

Biosynthesis in vitro of complement subcomponents C1q, C1s and C1 inhibitor by resting and stimulated human monocytes

Bensa, J., Reboul, A., & Colomb, M. G. (1983) · Biochemical Journal · doi:10.1042/bj2160385 · Cited by 128

Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement

Reid, K. B. M. (1979) · Biochemical Journal · doi:10.1042/bj1790367 · Cited by 127

Complement C1q Activates Tumor Suppressor WWOX to Induce Apoptosis in Prostate Cancer Cells

Hong, Q., Sze, C., Lin, S., Lee, M.-H., He, R., Schultz, L., Chang, J.-Y., Chen, S.-J., Boackle, R. J., Hsu, L., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005755 · Cited by 123

THE MACROMOLECULAR NATURE OF THE FIRST COMPONENT OF HUMAN COMPLEMENT

Naff, G. B., Pensky, J., & Lepow, I. H. (1964) · The Journal of Experimental Medicine · doi:10.1084/jem.119.4.593 · Cited by 122

Human C1qRp Is Identical with CD93 and the mNI-11 Antigen But Does Not Bind C1q

McGreal, E. P., Ikewaki, N., Akatsu, H., Morgan, B. P., & Gasque, P. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.10.5222 · Cited by 120

Cell-surface protein identified on phagocytic cells modulates the C1q-mediated enhancement of phagocytosis.

Guan, E., Robinson, S. L., Goodman, E. B., & Tenner, A. J. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.8.4005 · Cited by 119

Modular Organization of the Carboxyl-Terminal, Globular Head Region of Human C1q A, B, and C Chains

Kishore, U., Gupta, S. K., Perdikoulis, M. V., Kojouharova, M. S., Urban, B. C., & Reid, K. B. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.2.812 · Cited by 118

Clinical presentation of human C1q deficiency: How much of a lupus?

Stegert, M., Bock, M., & Trendelenburg, M. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.03.007 · Cited by 117

Reconstitution of the Complement Function in C1q-Deficient (C1qa−/−) Mice with Wild-Type Bone Marrow Cells

Petry, F., Botto, M., Holtappels, R., Walport, M. J., & Loos, M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.7.4033 · Cited by 117

Ultrastructure of the Human Complement Component, Clq

Shelton, E., Yonemasu, K., & Stroud, R. M. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.1.65 · Cited by 115

Insight into Schmid Metaphyseal Chondrodysplasia from the Crystal Structure of the Collagen X NC1 Domain Trimer

Bogin, O., Kvansakul, M., Rom, E., Singer, J., Yayon, A., & Hohenester, E. (2002) · Structure · doi:10.1016/s0969-2126(02)00697-4 · Cited by 114

C1q and phagocytosis: the perfect complement to a good meal

Galvan, M. D., Greenlee‐Wacker, M. C., & Bohlson, S. S. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0212099 · Cited by 113

Structure and homology of human C1q receptor (collectin receptor).

Malhotra, R., Willis, A. C., Jensenius, J. C., Jackson, J., & Sim, R. B. (1993) · PubMed Central · Cited by 111

The C1q Family of Proteins: Insights into the Emerging Non-Traditional Functions

Ghebrehiwet, B., Hosszu, K., Valentino, A., & Peerschke, E. I. B. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00052 · Cited by 106

Investigations on the C1q–Calreticulin–Phosphatidylserine Interactions Yield New Insights into Apoptotic Cell Recognition

Païdassi, H., Tacnet‐Delorme, P., Verneret, M., Gaboriaud, C., Houen, G., Duus, K., Ling, W. L., Arlaud, G. J., & Frachet, P. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.02.029 · Cited by 105

Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation

Clarke, E. V., Weist, B. M., Walsh, C. M., & Tenner, A. J. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0614-278r · Cited by 105

Antibody-Mediated Phagocytosis of the Amyloid β-Peptide in Microglia Is Differentially Modulated by C1q

Webster, S. D., Galvan, M. D., Ferran, E., Garzon-Rodriguez, W., Glabe, C. G., & Tenner, A. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7496 · Cited by 104

Complement component C1q inhibits β‐amyloid‐ and serum amyloid P‐induced neurotoxicity via caspase‐ and calpain‐independent mechanisms

Pisalyaput, K., & Tenner, A. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05012.x · Cited by 103

Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium

Bulla, R., Agostinis, C., Bossi, F., Rizzi, L., Debeus, A., Tripodo, C., Radillo, O., Seta, F. D., Ghebrehiwet, B., & Tedesco, F. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2007.12.025 · Cited by 101

Allostery in trypsin-like proteases suggests new therapeutic strategies

Gohara, D. W., & Di, E. (2011) · Trends in biotechnology · doi:10.1016/j.tibtech.2011.06.001 · Cited by 101

SREC-II, a New Member of the Scavenger Receptor Type F Family, Trans-interacts with SREC-I through Its Extracellular Domain

Ishii, J., Adachi, H., Aoki, J., Koizumi, H., Tomita, S., Suzuki, T., Tsujimoto, M., Inoue, K., & Arai, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206140200 · Cited by 101

Measurement of the association constants of the complexes formed between intact C1q or pepsin-treated C1q stalks and the unactivated or activated C1r2C1s2 tetramers

Siegelt, R. C., & Schumaker, V. N. (1983) · Molecular Immunology · doi:10.1016/0161-5890(83)90105-0 · Cited by 97

Calreticulin Is at the Surface of Circulating Neutrophils and Uses CD59 as an Adaptor Molecule

Ghiran, I. C., Klickstein, L. B., & Nicholson-Weller, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302306200 · Cited by 92

Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease

Fonseca, M. I., Chu, S., Berci, A. M., Benoit, M. E., Peters, D. G., Kimura, Y., & Tenner, A. J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-4 · Cited by 90

The Human C1q Globular Domain: Structure and Recognition of Non-Immune Self Ligands

Gaboriaud, C., Frachet, P., Thielens, N. M., & Arlaud, G. J. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00092 · Cited by 89

Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning

Steinberger, P., Szekeres, A., Wille, S., Stöckl, J., Selenko-Gebauer, N., Prager, E., Staffler, G., Madic, O., Stockinger, H. S. J., & Knapp, W. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.1.133 · Cited by 83

Complement Component C1q Regulates Macrophage Expression of Mer Tyrosine Kinase To Promote Clearance of Apoptotic Cells

Galvan, M. D., Foreman, D. B., Zeng, E., Tan, J. C., & Bohlson, S. S. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102920 · Cited by 82

Bispecific antibodies targeting tumor-associated antigens and neutralizing complement regulators increase the efficacy of antibody-based immunotherapy in mice

Macor, P., Secco, E., Mezzaroba, N., Zorzet, S., Durigutto, P., Gaiotto, T., Maso, L. D., Biffi, S., Garrovo, C., Capolla, S., et al. (2014) · Leukemia · doi:10.1038/leu.2014.185 · Cited by 81

Prognostic stromal gene signatures in breast cancer

Winslow, S., Leandersson, K., Edsjö, A., & Larsson, C. (2015) · Breast Cancer Research · doi:10.1186/s13058-015-0530-2 · Cited by 81

Novel collectin/C1q receptor mediates mast cell activation and innate immunity

Edelson, B. T., Stricker, T. P., Li, Z., Dickeson, S. K., Shepherd, V. L., Santoro, S. A., & Zutter, M. M. (2005) · Blood · doi:10.1182/blood-2005-06-2218 · Cited by 78

Mutational Analyses of the Recombinant Globular Regions of Human C1q A, B, and C Chains Suggest an Essential Role for Arginine and Histidine Residues in the C1q-IgG Interaction

Kojouharova, M. S., Gadjeva, M. G., Tsacheva, I., Zlatarova, A. S., Roumenina, L. T., Tchorbadjieva, M. I., Atanasov, B. P., Waters, P. J., Urban, B. C., Sim, R. B., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4351 · Cited by 78

Molecular cloning and characterization of the complementary DNA and gene coding for the B-chain of subcomponent C1q of the human complement system

Reid, K. B. M. (1985) · Biochemical Journal · doi:10.1042/bj2310729 · Cited by 78

Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis

Xavier, S., Sahu, R. K., Landes, S. G., Yu, J., Taylor, R. P., Ayyadevara, S., Megyesi, J. K., Stallcup, W. B., Duffield, J. S., Reis, E. S., et al. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00604.2016 · Cited by 78

Murine Low-Density Lipoprotein Receptor-Related Protein 1 (LRP) Is Required for Phagocytosis of Targets Bearing LRP Ligands but Is Not Required for C1q-Triggered Enhancement of Phagocytosis

Lillis, A. P., Greenlee‐Wacker, M. C., MIKHAILENKO, I. A., Pizzo, S. V., Tenner, A. J., Strickland, D. K., & Bohlson, S. S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.364 · Cited by 77

Siglec functions of microglia

Linnartz‐Gerlach, B., Kopatz, J., & Neumann, H. (2014) · Glycobiology · doi:10.1093/glycob/cwu044 · Cited by 77

Immune modulation of human dendritic cells by complement

Castellano, G., Woltman, A. M., Schlagwein, N., Xu, W., Schena, F. P., Daha, M. R., & van Kooten, C. (2007) · European Journal of Immunology · doi:10.1002/eji.200636845 · Cited by 76

VE-cadherin is a critical molecule for trophoblast?endothelial cell interaction in decidual spiral arteries

Bulla, R. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.09.015 · Cited by 75

C1q, antibodies and anti-C1q autoantibodies

Beurskens, F. J. M., van Schaarenburg, R. A., & Trouw, L. A. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.05.010 · Cited by 74

Complement modulation of T cell immune responses during homeostasis and disease

Clarke, E. V., & Tenner, A. J. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.3mr0214-109r · Cited by 74

RAGE binds C1q and enhances C1q-mediated phagocytosis

Ma, W., Rai, V., Hudson, B. I., Song, F., Schmidt, A. M., & Barile, G. R. (2012) · Cellular Immunology · doi:10.1016/j.cellimm.2012.02.001 · Cited by 73

Leukocyte-associated Ig-like receptor-1 is a novel inhibitory receptor for surfactant protein D

Nordkamp, M. J. M. O., van Eijk, M., Urbanus, R. T., Bont, L., Haagsman, H. P., & Meyaard, L. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ab0213-092rr · Cited by 73

Synthesis of classical pathway complement components by chondrocytes.

Bradley, K., North, J., Saunders, D., Schwaeble, W., Jeziorska, M., Woolley, D. E., & Whaley, K. (1996) · PubMed · Cited by 72

C1q regulation of dendritic cell development from monocytes with distinct cytokine production and T cell stimulation

Teh, B. K., Yeo, J. G., Lai, M. C., & Lu, J. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.02.006 · Cited by 71

Two way communication between neutrophils and dendritic cells

Ludwig, I. S., Geijtenbeek, T. B. H., & VANKOOYK, Y. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.03.009 · Cited by 69

C1q-Mediated Repression of Human Monocytes Is Regulated by Leukocyte-Associated Ig-Like Receptor 1 (LAIR-1)

Son, M., & Diamond, B. (2014) · Molecular Medicine · doi:10.2119/molmed.2014.00185 · Cited by 68

Completion of the amino acid sequences of the A and B chains of subcomponent C1q of the first component of human complement

Reid, K. B. M., Gagnon, J., & Frampton, J. D. (1982) · Biochemical Journal · doi:10.1042/bj2030559 · Cited by 67

Evidence That C1q Binds Specifically to CH2-like Immunoglobulin γ Motifs Present in the Autoantigen Calreticulin and Interferes with Complement Activation

Kovacs, H., Campbell, I. D., Strong, P., Johnson, S., Ward, F. J., Reid, K. B. M., & Eggleton, P. (1998) · Biochemistry · doi:10.1021/bi973197p · Cited by 65

Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites

Bally, I., Ancelet, S., Moriscot, C., Gonnet, F., Mantovani, A., Daniel, R., Schoehn, G., Arlaud, G. J., & Thielens, N. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304894110 · Cited by 63

Clq acts synergistically with phorbol dibutyrate to activate CR1‐mediated phagocytosis by human mononuclear phagocytes

Bobak, D. A., Frank, M. M., & Tenner, A. J. (1988) · European Journal of Immunology · doi:10.1002/eji.1830181220 · Cited by 63

β-Adrenergic receptor-induced activation of nerve growth factor gene transcription in rat cerebral cortex involves CCAAT/enhancer-binding protein δ

Colangelo, A. M., Johnson, P. F., & Mocchetti, I. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10920 · Cited by 62

DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells

Hosszu, K., Valentino, A., Vinayagasundaram, U., Vinayagasundaram, R., Joyce, M. G., Ji, Y., Peerschke, E. I. B., & Ghebrehiwet, B. (2012) · Blood · doi:10.1182/blood-2011-07-369728 · Cited by 61

Plasmacytoid Dendritic Cells and C1q Differentially Regulate Inflammatory Gene Induction by Lupus Immune Complexes

Santer, D. M., WIEDEMAN, A. E., Teal, T. H., Ghosh, P., & Elkon, K. B. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102797 · Cited by 57

The Complement System at the Embryo Implantation Site: Friend or Foe?

Bulla, R., Bossi, F., & Tedesco, F. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00055 · Cited by 56

Interaction of the globular domain of human C1q with Salmonella typhimurium lipopolysaccharide

Roumenina, L. T., Popov, K. T., Bureeva, S. V., Kojouharova, M. S., Gadjeva, M. G., Rabheru, S., Thakrar, R., Kaplun, A. P., & Kishore, U. (2008) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2008.04.029 · Cited by 54

Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression

Yabumoto, C., Akazawa, H., Yamamoto, R., Yano, M., Kudo-Sakamoto, Y., Sumida, T., Kamo, T., Yagi, H., Shimizu, Y., Saga-Kamo, A., et al. (2015) · Scientific Reports · doi:10.1038/srep14453 · Cited by 54

Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression

Son, M., Diamond, B., Volpe, B. T., Aranow, C. B., Mackay, M. C., & Santiago‐Schwarz, F. (2017) · Scientific Reports · doi:10.1038/s41598-017-00290-w · Cited by 54

Localization of ligand-binding sites on human C1q globular head region using recombinant globular head fragments and single-chain antibodies

Kojouharova, M. S., Tsacheva, I., Tchorbadjieva, M. I., Reid, K. B. M., & Kishore, U. (2003) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2003.08.003 · Cited by 53

Human C1q Induces Apoptosis in an Ovarian Cancer Cell Line via Tumor Necrosis Factor Pathway

Kaur, A., Sultan, S. H. A., Murugaiah, V., Pathan, A. A., Alhamlan, F. S., Karteris, E., & Kishore, U. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00599 · Cited by 53

gC1qR Expression in Normal and Pathologic Human Tissues

Dembitzer, F. R., Kinoshita, Y., Burstein, D. E., Phelps, R. G., Beasley, M. B., Garcia, R., Harpaz, N., Jaffer, S. M., Thung, S. N., Unger, P. D., et al. (2012) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155412440882 · Cited by 51

Deciphering Complement Receptor Type 1 Interactions with Recognition Proteins of the Lectin Complement Pathway

Jacquet, M., Lacroix, M., Ancelet, S., Gout, E., Gaboriaud, C., Thielens, N. M., & Rossi, V. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202451 · Cited by 51

Direct interaction between CD91 and C1q

Duus, K., Hansen, E. W., Tacnet‐Delorme, P., Frachet, P., Arlaud, G. J., Thielens, N. M., & Houen, G. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07762.x · Cited by 50

Decreased apopto-phagocytic gene expression in the macrophages of systemic lupus erythematosus patients

Majai, G. E., Kiss, E. V., Tarr, T., Zahuczky, G., Hartman, Z. C., Szegedi, G. Y., & Fésüs, L. (2013) · Lupus · doi:10.1177/0961203313511557 · Cited by 49

Ultrastructure of Human C1q Protein

Svehag, S., MANHEM, L., & Bloth, B. (1972) · Nature New Biology · doi:10.1038/newbio238117a0 · Cited by 47

Analysis of Human C1q by Combined Bottom-up and Top-down Mass Spectrometry

Pflieger, D., Przybylski, C., Gonnet, F., Caër, J. L., Lunardi, T., Arlaud, G. J., & Daniel, R. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900350-mcp200 · Cited by 47

C1q Regulatory Region Polymorphism Down-Regulating Murine C1q Protein Levels with Linkage to Lupus Nephritis

Miura-Shimura, Y., Nakamura, K., Ohtsuji, M., Tomita, H., Jiang, Y., Abe, M., Zhang, D., Hamano, Y., Tsuda, H., Hashimoto, H., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.3.1334 · Cited by 46

The non-inflammatory role of C1q during Her2/neu-driven mammary carcinogenesis

Bandini, S., Macagno, M., Hysi, A., Lanzardo, S., Conti, L., Bello, A., Riccardo, F., Ruiu, R., Merighi, I. F., Forni, G., et al. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1253653 · Cited by 46

Existence of Different but Overlapping IgG- and IgM-Binding Sites on the Globular Domain of Human C1q

Zlatarova, A. S., Rouseva, M. M., Roumenina, L. T., Gadjeva, M. G., Kolev, M. V., Dobrev, I., Olova, N. N., Ghai, R., Jensenius, J. C., Reid, K. B. M., et al. (2006) · Biochemistry · doi:10.1021/bi060539v · Cited by 45

Physical and Functional Interaction Between Cell-Surface Calreticulin and the Collagen Receptors Integrin α2β1 and Glycoprotein VI in Human Platelets

Elton, C. M., Smethurst, P. A., Eggleton, P., & Farndalerd, R. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613270 · Cited by 44

Molecular Basis for the Interaction of Low Density Lipoprotein Receptor-related Protein 1 (LRP1) with Integrin αMβ2

Ranganathan, S., Cao, C., Catania, J., Migliorini, M., Zhang, L., & Strickland, D. K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.265413 · Cited by 41

SIGN-R1, a C-type lectin, enhances apoptotic cell clearance through the complement deposition pathway by interacting with C1q in the spleen

Prabagar, M. G., Do, Y., Ryu, S. H., Park, J.-Y., Choi, H.-J., Choi, W.-S., Yun, T. J., Moon, J. J., Choi, I.-S., Ko, K., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.160 · Cited by 41

The dissociation properties of native C1

Ziccardi, R. J., & Tschopp, J. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(82)91536-4 · Cited by 40

The production and secretion of complement component C1q by human mast cells

van Schaarenburg, R. A., Suurmond, J., Habets, K. L. L., Brouwer, M. C., Wouters, D., Kurreeman, F. A. S., Huizinga, T. W. J., Toes, R. E. M., & Trouw, L. A. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.09.001 · Cited by 39

An amphioxus gC1q protein binds human IgG and initiates the classical pathway: Implications for a C1q‐mediated complement system in the basal chordate

Gao, Z., Li, M., Ma, J., & Zhang, S. (2014) · European Journal of Immunology · doi:10.1002/eji.201444734 · Cited by 37

C1q triggers neutrophil superoxide production by a unique CD18-dependent mechanism

Goodman, E. B., Anderson, D. C., & Tenner, A. J. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.58.2.168 · Cited by 37

Uncoupling complement C1s activation from C1q binding in apoptotic cell phagocytosis and immunosuppressive capacity

Colonna, L., Parry, G. C., Panicker, S., & Elkon, K. B. (2016) · Clinical Immunology · doi:10.1016/j.clim.2015.12.017 · Cited by 36

Complement research in the 18th–21st centuries: Progress comes with new technology

Sim, R. B., Schwaeble, W., & Fujita, T. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.06.011 · Cited by 34

CD91 interacts with mannan‐binding lectin (MBL) through the MBL‐associated serine protease‐binding site

Duus, K., Thielens, N. M., Lacroix, M., Tacnet‐Delorme, P., Frachet, P., Holmskov, U., & Houen, G. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07901.x · Cited by 32

The complement system of elasmobranches revealed by liver transcriptome analysis of a hammerhead shark, Sphyrna zygaena

Goshima, M., Sekiguchi, R., Matsushita, M., & Nonaka, M. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.03.009 · Cited by 32

Structural basis for selective recognition of endogenous and microbial polysaccharides by macrophage receptor SIGN-R1.

Silva-Martín, N., Bartual, S. G., Ramírez-Aportela, E., Chacón, P., Park, C., & Hermoso, J. (2014) · Structure · doi:10.1016/j.str.2014.09.001 · Cited by 31

Structural and Functional Characterization of a Single-Chain Form of the Recognition Domain of Complement Protein C1q

Moreau, C. P., Bally, I., Chouquet, A., Bottazzi, B., Ghebrehiwet, B., Gaboriaud, C., & Thielens, N. M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00079 · Cited by 31

C1q-Dependent Dendritic Cell Cross-Presentation of In Vivo–Formed Antigen–Antibody Complexes

Ho, N. I., Camps, M. G. M., de Haas, E. F. E., Trouw, L. A., Verbeek, J. S., & OSSENDORP, F. A. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1602169 · Cited by 30

Leukocyte integrins αLβ2, αMβ2 and αXβ2 as collagen receptors—Receptor activation and recognition of GFOGER motif

Lahti, M., Heino, J., & Käpylä, J. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.03.016 · Cited by 27

Differential Binding of IgG and of a HIV gp41 Peptide by the B Chain and A Chain Globular Head Sequences of C1q, Respectively

Kojouharova, M. S., Pantchev, I. Y., Tchorbadjieva, M. I., Reid, K. B. M., & Hoppe, H.-J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.8.4325 · Cited by 26

Inhibition of the Classical and Lectin Pathway of the Complement System by Recombinant LAIR-2

Nordkamp, M. J. M. O., Boross, P., Yildiz, C., Jansen, J. H. M., Leusen, J. H. W., Wouters, D., Urbanus, R. T., Hack, C. E., & Meyaard, L. (2013) · Journal of Innate Immunity · doi:10.1159/000354976 · Cited by 25

Complement Component C1q Programs a Pro-Efferocytic Phenotype while Limiting TNFα Production in Primary Mouse and Human Macrophages

Hulsebus, H. J., O’Conner, S. D., Smith, E. M., Jie, C., & Bohlson, S. S. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00230 · Cited by 24

De Novo Transcriptomic Analysis of Peripheral Blood Lymphocytes from the Chinese Goose: Gene Discovery and Immune System Pathway Description

Tariq, M., Chen, R., Yuan, H., Liu, Y., Wu, Y., Wang, J., & Xia, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121015 · Cited by 19

Generation of Novel Long-Acting Globular Adiponectin Molecules

Ge, H., Xiong, Y., Lemon, B. D., Lee, K. J., Tang, J., Wang, P., Weiszmann, J., Hawkins, N., Laudemann, J., Min, X., et al. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.03.062 · Cited by 17

Complement Protein C1q Interacts with DC-SIGN via Its Globular Domain and Thus May Interfere with HIV-1 Transmission

Pednekar, L., Pandit, H., Paudyal, B., Kaur, A., Al-Mozaini, M., Kouser, L., Ghebrehiwet, B., Mitchell, D. A., Madan, T., & Kishore, U. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00600 · Cited by 13

Preeclampsia is associated with defective production of C1q by invasive trophoblast

Agostinis, C., Bulla, R., Tripodo, C., Guarnotta, C., Seta, F. D., Tonon, M., Spessotto, P., Botto, M., & Tedesco, F. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.06.260 · Cited by 3

Human c1q induces apoptosis in an ovarian cancer cell line via tumor necrosis factor pathway

Kaur, A., Sultan, S. H. A., Murugaiah, V., Pathan, A. A., Alhamlan, F. S., Karteris, E., & Kishore, U. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.06.059 · Cited by 1

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

Chen, W.-T., Lu, A., Craessaerts, K., Pavie, B., Sala Frigerio, C., Corthout, N., Qian, X., Laláková, J., Kühnemund, M., Voytyuk, I., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.038 · Cited by 949

Neuroinflammation in Alzheimer disease

Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., et al. (2025) · Nature Reviews Immunology · doi:10.1038/s41577-024-01104-7 · Cited by 638

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

Farbehi, N., Patrick, R., Dorison, A., Xaymardan, M., Janbandhu, V. C., Wystub-Lis, K., Ho, J. W. K., Nordon, R. E., & Harvey, R. P. (2019) · eLife · doi:10.7554/elife.43882 · Cited by 570

New insights into the immune functions of complement

Reis, E. S., Mastellos, D. C., Hajishengallis, G., & Lambris, J. D. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0168-x · Cited by 485

The good, the bad, and the opportunities of the complement system in neurodegenerative disease

Schartz, N. D., & Tenner, A. J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02024-8 · Cited by 298

Thermodynamics of the complex formation between Mannan-binding lectin and MASPs

Schatz-Jakobsen, J. A., Kjær, T. R., Møller, J. B., Holmskov, U., Thiel, S., & Jensenius, J. C. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.06.091

Complement activation fragment C4a acts as effector molecule by signaling via protease-activated receptors 1 and 4

Ricklin, D., Wang, H., & Lambris, J. D. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.06.062

Complement profile and autoantibodies against adipocytes on acquired lipodystrophies

Corvillo, F., Aparicio, V., Garrido, S., Miguel, M. P. D., & López‐Trascasa, M. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.06.049 · Cited by 1

Complement and coagulation is activated in periodontitis in acute intermittent porphyria

Storjord, E., Airila‐Månsson, S., Karlsen, K., Madsen, M. R. S., Dahl, J. A., Landsem, A., Fure, H., Ludviksen, J. K., Nielsen, E. W., Mollnes, T. E., et al. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.06.065

The IL-6 receptor inhibitor tocilizumab attenuated expression of C5a receptor 1 and 2 in patients with myocardial infarction

Orrem, H. L., Nilsson, P. H., Pischke, S. E., Kleveland, O., Ekholt, K., Aukrust, P., Halvorsen, B. L., Gullestad, L. L., Barratt‐Due, A., & Mollnes, T. E. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.06.244