Tenner, Andrea J.

The role of the anaphylatoxins in health and disease

Klos, A., Tenner, A. J., Johswich, K.-O., Ager, R. R., Reis, E. S., & Köhl, J. (2009) · Molecular Immunology

Complement system in diseasesBiomarkers in Disease Mechanisms

Cited by 730

Neuroinflammation in Alzheimer disease

Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., et al. (2025) · Nature Reviews Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 638

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease.

Forner, S., Kawauchi, S., Balderrama-Gutierrez, G., Kramár, E. A., Matheos, D. P., Phan, J., Javonillo, D. I., Tran, K. M., Hingco, E., da Cunha, C., et al. (2021) · Scientific Data

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 501

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

Cribbs, D. H., Berchtold, N. C., Perreau, V., Coleman, P. D., Rogers, J., Tenner, A. J., & Cotman, C. W. (2012) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 499

A Dramatic Increase of C1q Protein in the CNS during Normal Aging

Stephan, A. H., Madison, D. V., Mateos, J. M., Fraser, D. A., Lovelett, E. A., Coutellier, L., Kim, L., Tsai, H.-H., Huang, E. J., Rowitch, D. H., et al. (2013) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsComplement system in diseases

Cited by 423

Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease

Fonseca, M. I., Zhou, J., Botto, M., & Tenner, A. J. (2004) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 345

Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain

Fonseca, M. I., Chu, S.-H., Hernandez, M. X., Fang, M. J., Modarresi, L., Selvan, P., MacGregor, G. R., & Tenner, A. J. (2017) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsComplement system in diseases

Cited by 337

beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.

Jiang, H., Burdick, D., Glabe, C. G., Cotman, C. W., & Tenner, A. J. (1994) · The Journal of Immunology

Alzheimer's disease research and treatmentsComplement system in diseases

Cited by 330

Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer’s disease

Matsuoka, Y., Picciano, M., Malester, B., LaFrancois, J., Zehr, C., Daeschner, J. M., Olschowka, J. A., Fonseca, M. I., O’Banion, M. K., Tenner, A. J., et al. (2001) · The American Journal of Pathology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 303

Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus

Rice, R. A., Spangenberg, E. E., Yamate-Morgan, H., Lee, R. J., Arora, R. P. S., Hernandez, M. X., Tenner, A. J., West, B. L., & Green, K. N. (2015) · Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Cited by 270

Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer’s Disease

Fonseca, M. I., Ager, R. R., Chu, S.-H., Yazan, O., Sanderson, S. D., LaFerla, F. M., Taylor, S. M., Woodruff, T. M., & Tenner, A. J. (2009) · The Journal of Immunology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 268

C1q: A fresh look upon an old molecule

Thielens, N. M., Tedesco, F., Bohlson, S. S., Gaboriaud, C., & Tenner, A. J. (2017) · Molecular Immunology

Complement system in diseasesBiomarkers in Disease Mechanisms

Cited by 237

Localization and Cell Association of C1q in Alzheimer's Disease Brain

Afagh, A., Cummings, B. J., Cribbs, D. H., Cotman, C. W., & Tenner, A. J. (1996) · Experimental Neurology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 224

Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer’s Disease

Javonillo, D. I., Tran, K. M., Phan, J., Hingco, E., Kramár, E. A., da Cunha, C., Forner, S., Kawauchi, S., Milinkeviciute, G., Gomez-Arboledas, A., et al. (2022) · Frontiers in Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 203

The complement cascade: Yin-Yang in neuroinflammation—neuro-protection and -degeneration

Alexander, J. J., Anderson, A. J., Barnum, S. R., Stevens, B., & Tenner, A. J. (2008) · Journal of Neurochemistry

Complement system in diseasesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 177

C1q-induced LRP1B and GPR6 Proteins Expressed Early in Alzheimer Disease Mouse Models, Are Essential for the C1q-mediated Protection against Amyloid-β Neurotoxicity

Benoit, M. E., Hernandez, M. X., Dinh, M. L., Benavente, F., Vasquez, O., & Tenner, A. J. (2013) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 155

Complement Component C1q Modulates the Phagocytosis of Aβ by Microglia

Webster, S. D., Yang, A. J., Margol, L., Garzon-Rodriguez, W., Glabe, C. G., & Tenner, A. J. (2000) · Experimental Neurology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 138

Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3-mediated removal by microglia

Linnartz, B., Kopatz, J., Tenner, A. J., & Neumann, H. (2012) · The Journal of Neuroscience

Complement system in diseasesGlycosylation and Glycoproteins Research

Cited by 134

Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury

Holden, S. S., Grandi, F. C., Aboubakr, O., Higashikubo, B., Cho, F. S., Chang, A. H., Forero, A. O., Morningstar, A. R., Mathur, V., Kuhn, L. J., et al. (2021) · Science

Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury Research

Cited by 133

Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank

Vitek, M. P., Araujo, J. A., Fossel, M., Greenberg, B. D., Howell, G. R., Rizzo, S. J. S., Seyfried, N. T., Tenner, A. J., Territo, P. R., Windisch, M., et al. (2020) · Alzheimer's & Dementia: Translational Research & Clinical Interventions

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 103

Analysis of the Putative Role of CR1 in Alzheimer’s Disease: Genetic Association, Expression and Function

Fonseca, M. I., Chu, S., Pierce, A. L., Brubaker, W. D., Hauhart, R. E., Mastroeni, D., Clarke, E. V., Rogers, J., Atkinson, J. P., & Tenner, A. J. (2016) · PLOS ONE

Alzheimer's disease research and treatmentsComplement system in diseases

Cited by 87

APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology

Tran, K. M., Kwang, N. E., Butler, C. A., Gomez-Arboledas, A., Kawauchi, S., Mar, C., Chao, D., Barahona, R. A., Da Cunha, C., Tsourmas, K. I., et al. (2025) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 28

A Commentary On: “NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease”. A cautionary note regarding C3aR

Woodruff, T. M., & Tenner, A. J. (2015) · Frontiers in Immunology

Neuroinflammation and Neurodegeneration MechanismsComplement system in diseases

Cited by 26

5xFAD/Abi3S209F mice display distinct age‐dependent effects on amyloid beta pathology and microglia dynamics

Butler, C. A., O'Gara, K., Mendoza‐Arvilla, A., Milinkeviciute, G., Da Cunha, C., Kawauchi, S., Rezaie, N., Liang, H. Y., Thach, A., Wang, S., et al. (2024) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 1