Cited by 95Nitric Oxide and Endothelin EffectsHemoglobin structure and functionRedox biology and oxidative stress

RBC NOS: regulatory mechanisms and therapeutic aspects

Özüyaman, Burcin, Grau, Marijke, Kelm, Malte, Merx, Marc W., Kleinbongard, Petra·2008·Trends in Molecular Medicine

Abstract

Nitric oxide (NO), one of the most important vascular signaling molecules, is primarily produced by endothelial NO synthase (eNOS). eNOS is tightly regulated by its substrate l-arginine, cofactors and diverse interacting proteins. Interestingly, an NO synthase (NOS) was described within red blood cells (RBC NOS), and it was recently shown to significantly contribute to the intravascular NO pool and to regulate physiologically relevant mechanisms. However, the regulatory mechanisms and clinical implications of RBC NOS are unknown. The aim of this review is to highlight intracellular RBC NOS interactions and the role of RBC NOS in RBC homeostasis. Furthermore, macro- and microvascular diseases affected by RBC-derived NO are discussed.

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Crossref · 10.1016/j.molmed.2008.05.002

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112 of 112 references verified0 citation errors · 0 not checkable

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Authors
Özüyaman, B., Grau, M., Kelm, M., Merx, M. W., & Kleinbongard, P.
Affiliations
Universitätsklinikum Aachen (DE)
Venue
Trends in Molecular Medicine
Publisher
Elsevier BV
Published
2008-07
Volume
14
Issue
7
Pages
314-322
ISSN
1471-4914 (ISSN-L)
OpenAlex
W2087302470
Cited by
95
References
113
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 9 · 2012: 7
FWCI
0.90
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Molecular Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • RWTH Publications (RWTH Aachen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
nitric oxide, endothelial nitric oxide synthase, L-arginine, microangiopathy, macroangiopathy
MeSH terms
Animals, Erythrocytes, Humans, Models, Biological, Nitric Oxide, Nitric Oxide Synthase, Nitric Oxide Synthase Type III

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