RBC NOS: regulatory mechanisms and therapeutic aspects
Abstract
Nitric oxide (NO), one of the most important vascular signaling molecules, is primarily produced by endothelial NO synthase (eNOS). eNOS is tightly regulated by its substrate l-arginine, cofactors and diverse interacting proteins. Interestingly, an NO synthase (NOS) was described within red blood cells (RBC NOS), and it was recently shown to significantly contribute to the intravascular NO pool and to regulate physiologically relevant mechanisms. However, the regulatory mechanisms and clinical implications of RBC NOS are unknown. The aim of this review is to highlight intracellular RBC NOS interactions and the role of RBC NOS in RBC homeostasis. Furthermore, macro- and microvascular diseases affected by RBC-derived NO are discussed.
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NO may be generated within the red blood cell by metabolism of nitrite or through the presence of an erythrocytic NOS.
“NO may be generated within the red blood cell by metabolism of nitrite or, intriguingly, through the presence of an erythrocytic NOS (57).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [57]
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Moss, M. B. (2010) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Aus der Klinik für Kardiologie, Pneumologie und Angiologie der Heinrich-Heine-Universität Düsseldorf
Kelm, M. (2013)
Self-citationРамазанов, В. В., Воловельская, Е. Л., Ніпот, О. Е., Yershov, S. S., Ershova, N. A., Rudenko, S. V., & Bondarenko, V. A. (2018) · Ukraïnsʹkij žurnal medicini bìologìï ta sportu · doi:10.26693/jmbs03.06.262
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- Authors
- Özüyaman, B., Grau, M., Kelm, M., Merx, M. W., & Kleinbongard, P.
- Affiliations
- Universitätsklinikum Aachen (DE)
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 14
- Issue
- 7
- Pages
- 314-322
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2087302470
- Cited by
- 95
- References
- 113
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 9 · 2012: 7
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- nitric oxide, endothelial nitric oxide synthase, L-arginine, microangiopathy, macroangiopathy
- MeSH terms
- Animals, Erythrocytes, Humans, Models, Biological, Nitric Oxide, Nitric Oxide Synthase, Nitric Oxide Synthase Type III
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