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Cited by 495Adipokines, Inflammation, and Metabolic DiseasesDiet, Metabolism, and DiseaseFatty Acid Research and Health

Inflammatory Links Between High Fat Diets and Diseases

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Duan, Yehui, Zeng, Liming, Zheng, Changbing, Song, Bo, Li, Fengna, Kong, Xiangfeng, Xu, Kang·2018·Frontiers in Immunology
DOI 10.3389/fimmu.2018.02649PMC PMC6243058
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Abstract

In recent years, chronic overnutrition, such as consumption of a high-fat diet (HFD), has been increasingly viewed as a significant modifiable risk factor for diseases such as diabetes and certain types of cancer. However, the mechanisms by which HFDs exert adverse effects on human health remains poorly understood. Here, this paper will review the recent scientific literature about HFD-induced inflammation and subsequent development of diseases and cancer, with an emphasis on mechanisms involved. Given the expanding global epidemic of excessive HFD intake, understanding the impacts of a HFD on these medical conditions, gaining great insights into possible underlying mechanisms, and developing effective therapeutic strategies are of great importance.

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  • Saturated fatty acid (palmitic acid) and monounsaturated fatty acid (oleic acid) are associated with increased NLRP3 inflammasome activity.

    “The saturated fatty acid (palmitic acid) and the monounsaturated fatty acid (oleic acid) are associated with the increased NLRP3 inflammasome activity [72, 73].”

    From HIV-TAT dysregulates microglial lipid metabolism through SREBP2/miR-124 axis: Implication of lipid droplet accumulation microglia in NeuroHIV (2025) · cites this paper as [73]

    The section “HFDs induce a systemic chronic low-grade inflammation” links elevated free fatty acids generally to inflammatory cytokines and macrophage activation, but does not address NLRP3 activity. Searches for NLRP3, palmitic acid, and oleic acid found no passage connecting either named fatty acid to increased NLRP3 inflammasome activity; the copy provides no page numbers. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Duan, Y., Zeng, L., Zheng, C., Song, B., Li, F., Kong, X., & Xu, K.
Affiliations
  • Chinese Academy of Sciences (CN)
  • Jiangxi Agricultural University (CN)
  • South China Agricultural University (CN)
Corresponding author
Xu, Kang
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2018-11-13
Volume
9
Pages
2649-2649
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2018.02649
PMC
PMC6243058
OpenAlex
W2901557220
Cited by
495
References
13
Citations by year
2026: 46 · 2025: 74 · 2024: 75 · 2023: 81 · 2022: 83 · 2021: 68 · 2020: 49 · 2019: 19
FWCI
4.86
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Key Project of Research and Development Plan of Hunan Province (2016NK2170)
  • National Natural Science Foundation of China (CARS 35, 2017QNCXTD_ZCS, 31601953)
  • Chinese Academy of Sciences (2017QNCXTD_ZCS, 2016326, CARS-35, 31601953, ZSZC-011)
  • Youth Innovation Promotion Association of the Chinese Academy of Sciences (CARS-35, 2016326, 2017QNCXTD_ZCS)
  • Earmarked Fund for China Agriculture Research System (CARS-35)
  • Youth Innovation Promotion Association (CARS-35)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
high-fat diet, inflammation, diabetes mellitus, cancer, disease mechanisms, modifiable risk factors, treatment options
MeSH terms
Animals, Diabetes Mellitus, Dietary Fats, Humans, Inflammation, Neoplasms

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