The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mitogen-activated protein kinases in male reproductive function
Open accessAbstract
Recent studies have shown that male reproductive function is modulated via the mitogen-activated protein kinase (MAPK) cascade. The MAPK cascade is involved in numerous male reproductive processes, including spermatogenesis, sperm maturation and activation, capacitation and acrosome reaction, before fertilization of the oocyte. In this review, we discuss the latest findings in this rapidly developing field regarding the role of MAPK in male reproduction in animal models and in human spermatozoa in vitro. This research will facilitate the design of future studies in humans, although much work is needed before this information can be used to manage male infertility and environmental toxicant-induced testicular injury in men, such as blood–testis-barrier disruption.
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Citations
Cites
Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
Owens, D. M., & Keyse, S. M. (2007) · Oncogene · doi:10.1038/sj.onc.1210412 · Cited by 777
Cited by
The Blood-Testis Barrier and Its Implications for Male Contraception
Cheng, C. Y., & Mruk, D. D. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.002790 · Cited by 927
Self-citationImpacts of environmental toxicants on male reproductive dysfunction
Wong, E. W. P., & Cheng, C. Y. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.01.001 · Cited by 281
Self-citationA local autocrine axis in the testes that regulates spermatogenesis
Cheng, C. Y., & Mruk, D. D. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.71 · Cited by 276
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Metadata
- Authors
- Li, M. W. M., Mruk, D. D., & Cheng, C. Y.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 15
- Issue
- 4
- Pages
- 159-168
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2069644908
- Cited by
- 181
- References
- 1
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Li, M. W. M., Mruk, D. D., & Cheng, C. Y. (2009). Mitogen-activated protein kinases in male reproductive function. Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2009.02.002
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