The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Impacts of environmental toxicants on male reproductive dysfunction
Open accessAbstract
Male infertility caused by exposure to environmental toxicants, such as cadmium, mercury, bisphenol A (BPA) and dioxin, is a global problem, particularly in industrialized countries. Studies in the testis and other organs have illustrated the importance of environmental toxicant-induced oxidative stress in mediating disruption to cell junctions. This, in turn, is regulated by the activation of PI3K/c-Src/FAK and MAPK signaling pathways, with the involvement of polarity proteins, leading to reproductive dysfunction, such as reduced sperm count and semen quality in men. In this review, we discuss how these findings can improve understanding of the modes of action of environmental toxicants in –testicular dysfunction. Thus, specific inhibitors and/or antagonists against signaling molecules in these pathways can possibly reverse and/or block the disruptive effects of toxicant-induced damage. Additional studies comparing high level acute exposure versus low level chronic exposure to environmental toxicants are also needed to elucidate fully the underlying molecular mechanism(s) by which these toxicants disrupt male reproductive function.
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Cites
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Exposure of the U.S. Population to Bisphenol A and 4- tertiary -Octylphenol: 2003–2004
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Cited by
The Blood-Testis Barrier and Its Implications for Male Contraception
Cheng, C. Y., & Mruk, D. D. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.002790 · Cited by 927
Self-citationThe Sertoli cell: one hundred fifty years of beauty and plasticity
França, L. R., Hess, R. A., Dufour, J. M., Hofmann, M. C., & Griswold, M. D. (2016) · Andrology · doi:10.1111/andr.12165 · Cited by 419
Zhang, X.-D., Sun, J., Zheng, X.-M., Zhang, J., Tan, L.-L., Fan, L.-L., Luo, Y.-X., Hu, Y.-F., Xu, S.-D., Zhou, H., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103312 · Cited by 47
Metadata
- Authors
- Wong, E. W. P., & Cheng, C. Y.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 32
- Issue
- 5
- Pages
- 290-299
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W1987338052
- Cited by
- 281
- References
- 107
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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