The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
A local autocrine axis in the testes that regulates spermatogenesis
Open accessAbstract
Spermiation—the release of mature spermatozoa from Sertoli cells into the seminiferous tubule lumen—occurs by the disruption of an anchoring device known as the apical ectoplasmic specialization (apical ES). At the same time, the blood–testis barrier (BTB) undergoes extensive restructuring to facilitate the transit of preleptotene spermatocytes. While these two cellular events take place at opposite ends of the Sertoli cell epithelium, the events are in fact tightly coordinated, as any disruption in either process will lead to infertility. A local regulatory axis exists between the apical ES and the BTB in which biologically active laminin fragments produced at the apical ES by the action of matrix metalloproteinase 2 can regulate BTB restructuring directly or indirectly via the hemidesmosome. Equally important, polarity proteins play a crucial part in coordinating cellular events within this apical ES–BTB–hemidesmosome axis. Additionally, testosterone and cytokines work in concert to facilitate BTB restructuring, which enables the transit of spermatocytes while maintaining immunological barrier function. Herein, we will discuss this important autocrine-based cellular axis that parallels the hormonal-based hypothalamic–pituitary–testicular axis that regulates spermatogenesis. This local regulatory axis is the emerging target for male contraception.
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Cites
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Cited by
The Blood-Testis Barrier and Its Implications for Male Contraception
Cheng, C. Y., & Mruk, D. D. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.002790 · Cited by 927
Self-citationThe Sertoli cell: one hundred fifty years of beauty and plasticity
França, L. R., Hess, R. A., Dufour, J. M., Hofmann, M. C., & Griswold, M. D. (2016) · Andrology · doi:10.1111/andr.12165 · Cited by 419
Impacts of environmental toxicants on male reproductive dysfunction
Wong, E. W. P., & Cheng, C. Y. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.01.001 · Cited by 281
Self-citationNutritional modifications in male infertility: a systematic review covering 2 decades
Giahi, L., Mohammadmoradi, S., Javidan, A., & Sadeghi, M. R. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuv059 · Cited by 149
Dynein 1 supports spermatid transport and spermiation during spermatogenesis in the rat testis
Wen, Q., Tang, E. I., Lui, W.-Y., Lee, W. M., Wong, C. K. C., Silvestrini, B., & Cheng, C. Y. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00114.2018 · Cited by 46
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Metadata
- Authors
- Cheng, C. Y., & Mruk, D. D.
- Venue
- Nature Reviews Endocrinology
- Published
- 2010-07
- Volume
- 6
- Issue
- 7
- Pages
- 380-395
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- OpenAlex
- W2006509394
- Cited by
- 276
- References
- 121
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- green
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