The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
MicroRNAs in cancer: biomarkers, functions and therapy
Open accessAbstract
The emergence of microRNAs has been one of the defining developments in cancer biology over the past decade, and the explosion of knowledge in this area has brought forward new diagnostic and therapeutic opportunities. The importance of microRNAs in cancer has been underlined by the identification of alterations in microRNA target binding sites and the microRNA processing machinery in tumor cells. Clinical trials utilizing microRNA profiling for patient prognosis and clinical response are now underway, and the first microRNA mimic entered the clinic for cancer therapy in 2013. In this article we review the potential applications of microRNAs for the clinical assessment of patient outcome in cancer, as well as in cancer monitoring and therapy.
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1 retracted
HMGA2 functions as a competing endogenous RNA to promote lung cancer progression
Kumar, M. S., Armenteros-Monterroso, E., East, P., Chakravorty, P., Matthews, N., Winslow, M. M., & Downward, J. (2013) · Nature · doi:10.1038/nature12785 · Cited by 255
RetractedHallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,637
Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969
Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 5,111
The widespread regulation of microRNA biogenesis, function and decay
Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672
miRBase: tools for microRNA genomics
Griffiths‐Jones, S., Saini, H. K., van Dongen, S., & Enright, A. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm952 · Cited by 4,432
Treatment of HCV Infection by Targeting MicroRNA
Janssen, H. L. A., Reesink, H. W., Lawitz, E., Zeuzem, S., Rodriguez‐Torres, M., Patel, K., van der Meer, A. J., Patick, A. K., Chen, A. P., Zhou, Y., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1209026 · Cited by 2,262
Research works printed but not linked: 1
- Choudhury, 2012, Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells, J. Clin. Invest., 122, 4059, 10.1172/JCI62925 · DOI
Cited by
Sorted by citations
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287
LncRNA-mediated regulation of cell signaling in cancer
Peng, W.-X., Koirala, P., & Mo, Y.-Y. (2017) · Oncogene · doi:10.1038/onc.2017.184 · Cited by 1,649
miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis
Condrat, C. E., Thompson, D. C., Barbu, M. G., Bugnar, O. L., Boboc, A. E., Crețoiu, D., Suciu, N., Creţoiu, S. M., & Voinea, S. C. (2020) · Cells · doi:10.3390/cells9020276 · Cited by 1,399
Hammond, S. M. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.05.001 · Cited by 1,324
siRNA versus miRNA as therapeutics for gene silencing
Lam, J. K. W., Chow, M. Y. T., Zhang, Y., & Leung, S. W. S. (2015) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2015.23 · Cited by 1,081
Metadata
- Authors
- Hayes, J., Peruzzi, P. P., & Lawler, S.
- Affiliations
- St James's University Hospital (GB)
- The Ohio State University Wexner Medical Center (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Lawler, Sean
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 20
- Issue
- 8
- Pages
- 460-469
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W1974254202
- Cited by
- 2,049
- References
- 79
- Citations by year
- 2026: 61 · 2025: 78 · 2024: 103 · 2023: 130 · 2022: 186 · 2021: 244 · 2020: 290 · 2019: 273 · 2018: 235 · 2017: 203 · 2016: 140 · 2015: 91 · 2014: 12
- FWCI
- 14.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- microRNA, cancer, biomarkers, microRNA processing, miRNA expression profiling, prognosis, cancer therapy, miRNA mimics, cancer monitoring
- MeSH terms
- Animals, Humans, Neoplasms, Prognosis, Biomarkers, Tumor, Genetic Therapy, Gene Expression Regulation, Neoplastic, MicroRNAs, Gene Regulatory Networks
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