Cited by 393Inflammasome and immune disordersImmune Response and InflammationCell death mechanisms and regulation

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Mitochondria: diversity in the regulation of the NLRP3 inflammasome

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Gurung, Prajwal, Lukens, John R., Kanneganti, Thirumala-Devi·2015·Trends in Molecular Medicine

DOI 10.1016/j.molmed.2014.11.008PMC PMC4352396

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Abstract

Recent studies have identified new roles for mitochondria in the regulation of autoinflammatory processes. Emerging data suggests that the release of danger signals from mitochondria in response to stress and infection promotes the formation of the inflammatory signaling platform known as inflammasomes. Activation of inflammasomes by damaged mitochondria results in caspase-1-dependent secretion of the inflammatory cytokines interleukin-1β (IL-1β) and IL-18, and an inflammatory form of cell death referred to as pyroptosis. Here, we review recently described mechanisms that have been proposed to be involved in mitochondria-mediated regulation of inflammasome activation and inflammation. In addition, we highlight how aberrant regulation of mitochondria-induced inflammasome activation centrally contributes to the inflammatory process that is responsible for obesity and associated metabolic diseases.

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Additional file 13 of Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation
Lim, J. R., Lee, H. J., Jung, Y. H., Kim, J. S., Chae, C. W., Kim, S. Y., & Han, H. J. (2020) · Figshare · doi:10.6084/m9.figshare.12799407
Additional file 8 of Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation
Lim, J. R., Lee, H. J., Jung, Y. H., Kim, J. S., Chae, C. W., Kim, S. Y., & Han, H. J. (2020) · Figshare · doi:10.6084/m9.figshare.12799428
Additional file 11 of Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation
Lim, J. R., Lee, H. J., Jung, Y. H., Kim, J. S., Chae, C. W., Kim, S. Y., & Han, H. J. (2020) · Figshare · doi:10.6084/m9.figshare.12799401
Additional file 6 of Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation
Lim, J. R., Lee, H. J., Jung, Y. H., Kim, J. S., Chae, C. W., Kim, S. Y., & Han, H. J. (2020) · Figshare · doi:10.6084/m9.figshare.12799422
Additional file 1 of Pinocembrin ameliorates intermittent hypoxia-induced neuroinflammation through BNIP3-dependent mitophagy in a murine model of sleep apnea
Gong, L.-J., Wang, X.-Y., Gu, W.-Y., & Wu, X. (2020) · Figshare · doi:10.6084/m9.figshare.13226305
Additional file 4 of Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation
Lim, J. R., Lee, H. J., Jung, Y. H., Kim, J. S., Chae, C. W., Kim, S. Y., & Han, H. J. (2020) · Figshare · doi:10.6084/m9.figshare.12799416
Additional file 7 of Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation
Lim, J. R., Lee, H. J., Jung, Y. H., Kim, J. S., Chae, C. W., Kim, S. Y., & Han, H. J. (2020) · Figshare · doi:10.6084/m9.figshare.12799425
Additional file 10 of Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation
Lim, J. R., Lee, H. J., Jung, Y. H., Kim, J. S., Chae, C. W., Kim, S. Y., & Han, H. J. (2020) · Figshare · doi:10.6084/m9.figshare.12799398
Additional file 9 of Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation
Lim, J. R., Lee, H. J., Jung, Y. H., Kim, J. S., Chae, C. W., Kim, S. Y., & Han, H. J. (2020) · Figshare · doi:10.6084/m9.figshare.12799431
Additional file 5 of Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation
Lim, J. R., Lee, H. J., Jung, Y. H., Kim, J. S., Chae, C. W., Kim, S. Y., & Han, H. J. (2020) · Figshare · doi:10.6084/m9.figshare.12799419
Additional file 3 of Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation
Lim, J. R., Lee, H. J., Jung, Y. H., Kim, J. S., Chae, C. W., Kim, S. Y., & Han, H. J. (2020) · Figshare · doi:10.6084/m9.figshare.12799413
Additional file 2 of Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation
Lim, J. R., Lee, H. J., Jung, Y. H., Kim, J. S., Chae, C. W., Kim, S. Y., & Han, H. J. (2020) · Figshare · doi:10.6084/m9.figshare.12799410
Additional file 12 of Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation
Lim, J. R., Lee, H. J., Jung, Y. H., Kim, J. S., Chae, C. W., Kim, S. Y., & Han, H. J. (2020) · Figshare · doi:10.6084/m9.figshare.12799404
The roles of endoplasmic reticulum stress and Bax inhibitor-1 in non-alcoholic fatty liver disease
Lebeaupin, C. (2018) · theses.fr (ABES) · doi:10.70675/de500ab2z3c59z484dz8f58z7c3173626c42
Effet anti-calcifiant et anti-inflammatoire du Thiosulfate de sodium dans les calcifications ectopiques
Gauffenic, A. (2023) · theses.fr (ABES) · doi:10.70675/53a7d3b9z29c3z4227zae73z5810b3bf6448
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Turkanov, I. F., Германовна, А. Л., Flaks, G. A., Bolotskova, P. N., & Gryaznov, V. G. (2026) · Scientific Notes Kazan Bauman State Academy of Veterinary Medicine · doi:10.31588/2413_4201_1883_1_265_59
Fuzheng Jiedu Tongluo Granule Alleviates Cerebral Ischemia/reperfusion Injury-induced Inflammation By Inhibiting Drp1-mediated TXNIP/NLRP3 Pathway
Chen, Y., Zhou, C., Gong, M.-Q., Lai, F., Wan, H., & He, Y. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05920-x
Sex-dependent differences in mitochondrial protein acetylation in metabolic condition, oxidative stress, vascular dysfunction, hypertension, and cardiovascular disease
Dikalova, A., & Dikalov, S. (2026) · Clinical Science · doi:10.1042/cs20250226
Therapeutic Effects of Zhilong Huoxue Tongyu Capsule on Oxidative Stress and Neuroprotection in a Rat Model of Intracerebral Hemorrhage
Wang, L., Zhu, G., Luo, G., Yang, L., Ren, W., Wang, R., & Xu, H. (2026) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-026-10297-8
Asiatic Acid Mitigates PM2.5-Elicited Cardiomyocyte Pyroptosis via Suppression of mtDNA-Driven cGAS-STING-NLRP3 Signaling
Chen, Z., Yu, X., Tang, L., Zhao, Y., Yang, X. D., Su, R., & Xiong, Z. (2026) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001858
Negotiating in a Foreign Land : Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles
Bhattacharjee, S. (2026) · Advanced Materials Interfaces · doi:10.1002/admi.70595
Diosmin Attenuates Age-Associated Vascular Oxidative Stress and Endothelial Dysfunction in Aged Rats
Valdiserra, G., Salvo, C. D., Fornai, M., Pellegrini, C., Campigli, L., Mengozzi, A., Cappelli, F., Duranti, E., Ippolito, C., Colucci, R., et al. (2026) · Foods · doi:10.3390/foods15162779
Unraveling the pyroptosis-mitophagy axis: from molecular mechanisms to therapeutic opportunities
Ban, J., 陈然兴, Ao, L., Zhao, H., Li, J., Wei, Y., & Huang, G. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1950578

Authors: Gurung, P., Lukens, J. R., & Kanneganti, T.-D.
Affiliations: St. Jude Children's Research Hospital (US)
ORCID: Gurung, Prajwal
Lukens, John R.
Kanneganti, Thirumala-Devi
Venue: Trends in Molecular Medicine
Publisher: Elsevier BV
Published: 2015-03
Volume: 21
Issue: 3
Pages: 193-201
ISSN: 1471-4914 (ISSN-L)
DOI: 10.1016/j.molmed.2014.11.008
PMC: PMC4352396
OpenAlex: W1999224782
Cited by: 393
References: 89
Citations by year: 2026: 19 · 2025: 26 · 2024: 32 · 2023: 37 · 2022: 28 · 2021: 45 · 2020: 57 · 2019: 37 · 2018: 32 · 2017: 32 · 2016: 33 · 2015: 14
FWCI: 2.48
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: American Lebanese Syrian Associated Charities
National Institutes of Health
National Cancer Institute (R01CA163507, CA163507)
National Institute of Allergy and Infectious Diseases (AI101935, R01AI101935, R37AI101935)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR056296, AR-056296)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: mitochondria, NLRP3 inflammasome, inflammasome activation, autoinflammation, caspase-1, IL-1β, IL-18, pyroptosis, mitochondrial damage, mitochondrial stress, obesity, metabolic inflammation
MeSH terms: Carrier Proteins, Humans, Mitochondria, Models, Biological, Obesity, Reactive Oxygen Species, Inflammasomes

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Mitochondria: diversity in the regulation of the NLRP3 inflammasome

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