Lukens, John R.

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.

Louveau, A., Herz, J., Alme, M. N., Salvador, A. F., Dong, M. Q., Viar, K. E., Herod, S. G., Knopp, J., Setliff, J. C., Lupi, A. L., et al. (2018) · Nature Neuroscience

Lymphatic System and DiseasesCerebrospinal fluid and hydrocephalus

Cited by 956

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

Gurung, P., Lukens, J. R., & Kanneganti, T.-D. (2015) · Trends in Molecular Medicine

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 393

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis.

Bolte, A. C., Dutta, A. B., Hurt, M. E., Smirnov, I., Kovacs, M. A., McKee, C. A., Ennerfelt, H. E., Shapiro, D., Nguyen, B. H., Frost, E. L., et al. (2020) · Nature Communications

Traumatic Brain Injury and Neurovascular DisturbancesCerebrospinal fluid and hydrocephalus

Cited by 357

Dealing with danger in the CNS: the response of the immune system to injury

Gadani, S. P., Walsh, J. T., Lukens, J. R., & Kipnis, J. (2015) · Neuron

Neuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular Disturbances

Cited by 342

Dietary modulation of the microbiome affects autoinflammatory disease

Lukens, J. R., Gurung, P., Vogel, P., Johnson, G. R., Carter, R. A., McGoldrick, D. J., Bandi, S. R., Calabrese, C. R., Walle, L. V., Lamkanfi, M., et al. (2014) · Nature

Inflammasome and immune disordersGut microbiota and health

Cited by 314

SYK coordinates neuroprotective microglial responses in neurodegenerative disease

Ennerfelt, H., Frost, E. L., Shapiro, D. A., Holliday, C., Zengeler, K. E., Voithofer, G., Bolte, A. C., Lammert, C. R., Kulas, J. A., Ulland, T. K., et al. (2022) · Cell

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 297

Nascent astrocyte particles differ from lipoproteins in CSF

LaDu, M. J., Gilligan, S. M., Lukens, J. R., Cabana, V. G., Reardon, C. A., Van Eldik, L. J., & Holtzman, D. M. (1998) · Journal of Neurochemistry

Cholesterol and Lipid MetabolismCerebrospinal fluid and hydrocephalus

Cited by 285

AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment

Lammert, C. R., Frost, E. L., Bellinger, C. E., Bolte, A. C., McKee, C. A., Hurt, M. E., Paysour, M. J., Ennerfelt, H. E., & Lukens, J. R. (2020) · Nature

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 223

Unique Lipoproteins Secreted by Primary Astrocytes From Wild Type, apoE (−/−), and Human apoE Transgenic Mice

Fagan, A. M., Holtzman, D. M., Munson, G., Mathur, T., Schneider, D., Chang, L. K., Getz, G. S., Reardon, C. A., Lukens, J., Shah, J. A., et al. (1999) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism

Cited by 222

Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis

Weinlich, R., Oberst, A., Dillon, C. P., Janke, L. J., Milasta, S., Lukens, J. R., Rodriguez, D. A., Gurung, P., Savage, C., Kanneganti, T. D., et al. (2013) · Cell Reports

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 157

The Alzheimer's disease risk factor INPP5D restricts neuroprotective microglial responses in amyloid beta‐mediated pathology

Samuels, J. D., Moore, K. A., Ennerfelt, H. E., Johnson, A. M., Walsh, A. E., Price, R. J., & Lukens, J. R. (2023) · Alzheimer's & Dementia

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 46

STING Deletion Protects Against Amyloid β‐induced Alzheimer's Disease Pathogenesis

Thanos, J. M., Campbell, O. C., Cowan, M. N., Bruch, K. R., Moore, K. A., Ennerfelt, H. E., Natale, N. R., Mangalmurti, A., Kerur, N., & Lukens, J. R. (2025) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 26

Microglia pack a toolbox for life

Zengeler, K. E., & Lukens, J. R. (2024) · Trends in Immunology

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 19