Acute myocardial infarction: ‘telomerasing’ for cardioprotection
Abstract
Reactivating the telomerase gene through gene therapy after acute myocardial infarction (AMI) has been recently reported to improve survival in mice. Given that regular physical exercise also activates this gene, therapeutic and lifestyle interventions targeting telomerase need to be explored as possible additions to the current armamentarium for myocardial regeneration.
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Exercise-mediated improvement in myocardial regenerative capacity after MI is mediated by activation of telomerase in damaged cardiac tissues.
“or activation of telomerase in damaged cardiac tissues 156”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [156]
Cites
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“120 ERBB4 signalling are among other mechanisms implicated in exercise-induced myocardial repair after MI. 121,122 Although this is still an evolving concept, it may represent a promising approach to prevent cardiac damage by means of ET-activated mechanisms.”
BackgroundPhysical Activity, Physical Fitness, and Leukocyte Telomere Length
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“It has emerged as the leading cause of death and disability worldwide.(1) There are many well-known risk factors for CAD, such as obesity and hypertension.”
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BackgroundGao, J., Guo, H., Li, J., Zhan, M., You, Y., Xin, G., Liu, Z., Fan, X., Gao, Q., Liu, J., et al. (2024) · Chinese Medicine · doi:10.1186/s13020-024-00976-0 · Cited by 9 · see citing works
“…therapy specifically aimed in the improvement of heart function, decreasing scar formation, attenuated the gene expression related with inflammation or proliferation, increased tissue remodelling and potentially regeneration, leading to increased survival rate by 17% compared to controls [18, 24].”
BackgroundTHE DOSE-DEPENDENT EFFECTS OF CAFFEINE AND BETAINE ON TELOMERASE ENZYME ACTIVITY IN MICE
TIKIRDIK, M., Mutlu, A. G., Alkan, İ., Yıldız, H., Korkmaz, D., & Topal, A. (2024) · Acta Biológica Colombiana · doi:10.15446/abc.v29n2.99155
“Telomerase is the only DNA polymerase that functions as reverse transcriptase, completely covering the ends of linear chromosomes and rebuilding telomeric sequences (Sanchis-Gomar and Lucia 2015).”
BackgroundAmani, S., Mirzajani, E., Kassaee, S. M., Mahmoudi, M., & Mirbolouk, F. (2023) · Crescent Journal of Medical and Biological Sciences · doi:10.34172/cjmb.2023.3670
“Coronary artery disease (CAD) is the leading cause of global death, especially in developed countries and some developing countries (1).”
Gao, J., Guo, H., Li, J., Zhan, M., You, Y., Xin, G., Liu, Z., Xiaodi, F., Gao, Q., Liu, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26787196
Gao, J., Guo, H., Li, J., Zhan, M., You, Y., Xin, G., Liu, Z., Xiaodi, F., Gao, Q., Liu, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26787187
Gao, J., Guo, H., Li, J., Zhan, M., You, Y., Xin, G., Liu, Z., Xiaodi, F., Gao, Q., Liu, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26787190
Gao, J., Guo, H., Li, J., Zhan, M., You, Y., Xin, G., Liu, Z., Xiaodi, F., Gao, Q., Liu, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26787199
- Authors
- Sanchis-Gomar, F., & Lucia, A.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 21
- Issue
- 4
- Pages
- 203-205
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W1978998947
- Cited by
- 15
- References
- 10
- Citations by year
- 2024: 6 · 2023: 2 · 2022: 1 · 2021: 1 · 2018: 1 · 2017: 2 · 2015: 2
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- ABACUS. Repositorio de Producción Científica (Universidad Europea) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- acute myocardial infarction, telomerase, cardioprotection, cardiac regeneration, physical activity, lifestyle intervention, cardiac survival
- MeSH terms
- Acute Disease, Animals, Disease Models, Animal, Motor Activity, Myocardial Infarction, Genetic Therapy, Telomerase, Mice
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