Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction
Open accessAbstract
Coronary heart disease is one of the main causes of death in the developed world, and treatment success remains modest, with high mortality rates within 1 year after myocardial infarction (MI). Thus, new therapeutic targets and effective treatments are necessary. Short telomeres are risk factors for age-associated diseases, including heart disease. Here we address the potential of telomerase (Tert) activation in prevention of heart failure after MI in adult mice. We use adeno-associated viruses for cardiac-specific Tert expression. We find that upon MI, hearts expressing Tert show attenuated cardiac dilation, improved ventricular function and smaller infarct scars concomitant with increased mouse survival by 17% compared with controls. Furthermore, Tert treatment results in elongated telomeres, increased numbers of Ki67 and pH3-positive cardiomyocytes and a gene expression switch towards a regeneration signature of neonatal mice. Our work suggests telomerase activation could be a therapeutic strategy to prevent heart failure after MI.
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AAV-mediated Tert expression in adult mice improves survival after myocardial infarction.
“AAV-mediated Tert expression in adult mice improved their survival following myocardial infarction112.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [112]
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- Authors
- Bär, C., de Jesus, B. B., Serrano, R., Tejera, A., Ayuso, E., Jimenez, V., Formentini, I., Bobadilla, M., Mizrahi, J., de Martino, A., Gomez, G., Pisano, D., Mulero, F., Wollert, K. C., Bosch, F., & Blasco, M. A.
- Affiliations
- Spanish National Cancer Research Centre (ES)
- Universitat Autònoma de Barcelona (ES)
- F. Hoffmann-La Roche AG (CH)
- Medizinische Hochschule Hannover (DE)
- Venue
- Nature Communications
- Published
- 2014-12-18
- Volume
- 5
- Issue
- 1
- Pages
- 5863-5863
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4871230
- OpenAlex
- W1991425040
- Cited by
- 162
- References
- 69
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 20 · 2023: 13 · 2022: 14 · 2021: 15 · 2020: 19 · 2019: 13 · 2018: 11 · 2017: 18 · 2016: 13 · 2015: 7
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Eli Lilly and Company
- European Commission (201630, 200950)
- AXA Research Fund
- Generalitat de Catalunya
- Ministerio de Economía y Competitividad
- Institució Catalana de Recerca i Estudis Avançats
- FP7 Ideas: European Research Council (232854)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- telomerase, telomerase reverse transcriptase, myocardial infarction, cardioprotection, heart failure, telomere length, cardiomyocyte proliferation, cardiac regeneration, cardiac dilatation, ventricular function, AAV gene delivery, cardiac-specific gene expression, infarct scar
- MeSH terms
- Dependovirus, Animals, Genetic Vectors, Heart Failure, Histones, Humans, Mice, Inbred C57BL, Mice, Transgenic, Myocardial Infarction, Myocardium, Genetic Therapy, Gene Expression, Telomere, Telomerase, Ki-67 Antigen, Ventricular Remodeling, Gene Expression Profiling, Myocytes, Cardiac, Mice, HEK293 Cells, Molecular Sequence Annotation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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