The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Siderophores in Iron Metabolism: From Mechanism to Therapy Potential
Open accessAbstract
Iron is an essential nutrient for life. During infection, a fierce battle of iron acquisition occurs between the host and bacterial pathogens. Bacteria acquire iron by secreting siderophores, small ferric iron binding molecules. In response, host immune cells secrete lipocalin 2 (also known as siderocalin), a siderophore-binding protein, to prevent bacterial reuptake of iron-loaded siderophores. To counter this threat, some bacteria can produce lipocalin 2-resistant siderophores. This review discusses the recently described molecular mechanisms of siderophore iron trafficking between host and bacteria, highlighting the therapeutic potential of exploiting pathogen siderophore machinery for the treatment of antibiotic-resistant bacterial infections. As the latter reflect a persistent problem in hospital settings, siderophore-targeting or siderophore-based compounds represent a promising avenue to combat such infections.
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Multistate point-prevalence survey of health care-associated infections
Magill, S. S., Edwards, J. R., Bamberg, W., Beldavs, Z. G., Dumyati, G., Kainer, M. A., Lynfield, R., Maloney, M., McAllister-Hollod, L., Nadle, J., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1306801 · Cited by 3,931
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
Pickrell, A. M., & Youle, R. J. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.007 · Cited by 2,310
Chemistry and biology of siderophores
Hider, R. C., & Kong, X. (2010) · Natural Product Reports · doi:10.1039/b906679a · Cited by 1,722
Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens
Santajit, S., & Indrawattana, N. (2016) · BioMed Research International · doi:10.1155/2016/2475067 · Cited by 1,641
HIF transcription factors, inflammation, and immunity
Palazon, A., Goldrath, A. W., Nizet, V., & Johnson, R. S. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.008 · Cited by 1,195
The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria
Pagès, J.-M., James, C. E., & Winterhalter, M. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1994 · Cited by 939
Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease
Bogdan, A. R., Miyazawa, M., Hashimoto, K., & Tsuji, Y. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.11.012 · Cited by 893
Self-citationHIF-1α expression regulates the bactericidal capacity of phagocytes
Peyssonnaux, C., Datta, V., Cramer, T., Doedens, A., Theodorakis, E. A., Gallo, R. L., Hurtado-Ziola, N., Nizet, V., & Johnson, R. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23865 · Cited by 702
Winstanley, C., O’Brien, S., & Brockhurst, M. A. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.01.008 · Cited by 689
Hospital Epidemiology and Infection Control in Acute-Care Settings
Sydnor, E. R. M., & Perl, T. M. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00027-10 · Cited by 652
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Bradley, J. M., Svistunenko, D. A., Wilson, M. T., Hemmings, A. M., Moore, G. R., & Le Brun, N. E. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.007746 · Cited by 140
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Metadata
- Authors
- Wilson, B. R., Bogdan, A. R., Miyazawa, M., Hashimoto, K., & Tsuji, Y.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 22
- Issue
- 12
- Pages
- 1077-1090
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2548630962
- Cited by
- 477
- References
- 71
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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