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Cited by 702

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

HIF-1α expression regulates the bactericidal capacity of phagocytes

Open access
Peyssonnaux, Carole, Datta, Vivekanand, Cramer, Thorsten, Doedens, Andrew, Theodorakis, Emmanuel A., Gallo, Richard L., Hurtado-Ziola, Nancy, Nizet, Victor, Johnson, Randall S.·2005·Journal of Clinical Investigation
DOI 10.1172/jci23865
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Abstract

Hypoxia is a characteristic feature of the tissue microenvironment during bacterial infection. Here we report on our use of conditional gene targeting to examine the contribution of hypoxia-inducible factor 1, alpha subunit (HIF-1alpha) to myeloid cell innate immune function. HIF-1alpha was induced by bacterial infection, even under normoxia, and regulated the production of key immune effector molecules, including granule proteases, antimicrobial peptides, nitric oxide, and TNF-alpha. Mice lacking HIF-1alpha in their myeloid cell lineage showed decreased bactericidal activity and failed to restrict systemic spread of infection from an initial tissue focus. Conversely, activation of the HIF-1alpha pathway through deletion of von Hippel-Lindau tumor-suppressor protein or pharmacologic inducers supported myeloid cell production of defense factors and improved bactericidal capacity. HIF-1alpha control of myeloid cell activity in infected tissues could represent a novel therapeutic target for enhancing host defense.

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Citations

Cites

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Metadata

Authors
Peyssonnaux, C., Datta, V., Cramer, T., Doedens, A., Theodorakis, E. A., Gallo, R. L., Hurtado-Ziola, N., Nizet, V., & Johnson, R. S.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2005-07-01
Volume
115
Issue
7
Pages
1806-1815
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci23865
OpenAlex
W2111850449
Cited by
702
References
7
FWCI
7.79
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: HIF-1α expression regulates the bactericidal capacity of phagocytes. https://app.cochat.ai/papers/10.1172/jci23865
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Peyssonnaux, C., Datta, V., Cramer, T., Doedens, A., Theodorakis, E. A., Gallo, R. L., Hurtado-Ziola, N., Nizet, V., & Johnson, R. S. (2005). HIF-1α expression regulates the bactericidal capacity of phagocytes. Journal of Clinical Investigation. https://doi.org/10.1172/jci23865

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