Osteosarcoma: Molecular Pathogenesis and iPSC Modeling

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221 · see citing works

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765 · see citing works

Blinded by the Light: The Growing Complexity of p53

Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163 · see citing works

Notch Signaling Augments BMP9-Induced Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells (MSCs)

Liao, J., Wei, Q., Zou, Y., Fan, J., Song, D., Cui, J., Zhang, W., Zhu, Y., Ma, C., Hu, X. Y., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000471945 · Cited by 2,742 · see citing works

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

Stephens, P. J., Greenman, C. D., Fu, B., Yang, F., Bignell, G. R., Mudie, L. J., Pleasance, E. D., Lau, K. W., Beare, D., Stebbings, L. A., et al. (2011) · Cell · doi:10.1016/j.cell.2010.11.055 · Cited by 2,414 · see citing works

The Epidemiology of Osteosarcoma

Ottaviani, G., & Jaffe, N. (2009) · Cancer treatment and research · doi:10.1007/978-1-4419-0284-9_1 · Cited by 1,793 · see citing works

Effects of an Rb mutation in the mouse

Jacks, T., Fazeli, A., Schmitt, E. M., Bronson, R. T., Goodell, M. A., & Weinberg, R. A. (1992) · Nature · doi:10.1038/359295a0 · Cited by 1,755 · see citing works

Soft-Tissue Sarcomas, Breast Cancer, and Other Neoplasms

Li, F. P., & FRAUMENI, J. F. (1969) · Annals of Internal Medicine · doi:10.7326/0003-4819-71-4-747 · Cited by 1,514 · see citing works

The Bloom's syndrome gene product is homologous to RecQ helicases

Ellis, N. A., Groden, J. L., Ye, T.-Z., Straughen, J. E., Lennon, D. J., Ciocci, S., Proytcheva, M. A., & GERMAN, J. L. (1995) · Cell · doi:10.1016/0092-8674(95)90105-1 · Cited by 1,385 · see citing works

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

Olive, K. P., Tuveson, D. A., Ruhe, Z. C., Yin, B., Willis, N. A., Bronson, R. T., Crowley, D., & Jacks, T. (2004) · Cell · doi:10.1016/j.cell.2004.11.004 · Cited by 1,308 · see citing works

Translational biology of osteosarcoma

Kansara, M., Teng, M. W., Smyth, M. J., & Thomas, D. M. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3838 · Cited by 1,294 · see citing works

A cancer family syndrome in twenty-four kindreds.

Li, F. P., Fraumeni, J. F., Mulvihill, J. J., Blattner, W. A., Dreyfus, M., Tucker, M., & Miller, R. (1988) · PubMed · Cited by 1,293 · see citing works

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

Lee, E. Y.-H. P., Chang, C.-Y., Hu, N., Wang, Y.-C. J., Lai, C., Herrup, K., Lee, W., & Bradley, A. (1992) · Nature · doi:10.1038/359288a0 · Cited by 1,264 · see citing works

Mutant p53: one name, many proteinsPreprint

Freed-Pastor, W. A., & Prives, C. L. (2012) · Genes & Development · doi:10.1101/gad.190678.112 · Cited by 1,246 · see citing works

The Bloom's syndrome helicase suppresses crossing over during homologous recombination

Wu, L., & Hickson, I. D. (2003) · Nature · doi:10.1038/nature02253 · Cited by 1,087 · see citing works

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome

Lang, G. A., Iwakuma, T., Suh, Y.-A., Liu, G., Rao, V. A., Parant, J. M., Valentin-Vega, Y. A., Terzian, T., Caldwell, L. C., Strong, L. C., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.006 · Cited by 1,069 · see citing works

Requirement for a functional Rb-1 gene in murine development

Clarke, A. R., Maandag, E. R., van ROON, M. A., van der Lugt, N. M. T., van der Valk, M., Hooper, M., Berns, A. J. M., & Rielef, H. T. (1992) · Nature · doi:10.1038/359328a0 · Cited by 1,006 · see citing works

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

Freed-Pastor, W. A., Mizuno, H., Zhao, X., Langerød, A., Moon, S.-H., Rodriguez-Barrueco, R., Barsotti, A., Chicas, A., Li, W., Polotskaia, A., et al. (2012) · Cell · doi:10.1016/j.cell.2011.12.017 · Cited by 865 · see citing works

Ribosomopathies: human disorders of ribosome dysfunction

Narla, A., & Ebert, B. L. (2010) · Blood · doi:10.1182/blood-2009-10-178129 · Cited by 806 · see citing works

p62/ SQSTM 1 functions as a signaling hub and an autophagy adaptor

Katsuragi, Y., Ichimura, Y., & Komatsu, M. (2015) · FEBS Journal · doi:10.1111/febs.13540 · Cited by 795 · see citing works

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

Chen, X., Bahrami, A., Pappo, A., Easton, J., Dalton, J., Hedlund, E., Ellison, D., Shurtleff, S., Wu, G., Wei, L., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.003 · Cited by 752 · see citing works

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

Yamasaki, L., Jacks, T., Bronson, R. T., Goillot, E., Harlow, E., & Dyson, N. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81254-4 · Cited by 699 · see citing works

Cancer Incidence After Retinoblastoma

Wong, F. L. (1997) · JAMA · doi:10.1001/jama.278.15.1262 · Cited by 689 · see citing works

Beyond Li Fraumeni Syndrome: Clinical Characteristics of Families With p53 Germline Mutations

Hagman, K. D. F., Noltner, K., Buzin, C. H., Gu, D., Wen, C. Y., Nguyen, V. Q., Han, J., Lowstuter, K. J., Longmate, J., Sommer, S. S., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.16.6959 · Cited by 607 · see citing works

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

Durán, Á., Amanchy, R., Linares, J. F., Joshi, J. P., Abu‐Baker, S., Porollo, A., Hansen, M., Moscat, J., & Díaz-Meco, M. T. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.038 · Cited by 502 · see citing works

The Bloom's syndrome gene product promotes branch migration of Holliday junctions

Karow, J., Constantinou, A., Li, J., West, S. C., & Hickson, I. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100448097 · Cited by 502 · see citing works

Induced Pluripotent Stem Cells Meet Genome Editing

Hockemeyer, D., & Jaenisch, R. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.04.013 · Cited by 499 · see citing works

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

Zhu, J., Sammons, M. A., Donahue, G., Dou, Z., Vedadi, M., Getlik, M., Barsyte-Lovejoy, D., Al-awar, R., Katona, B. W., Shilatifard, A., et al. (2015) · Nature · doi:10.1038/nature15251 · Cited by 493 · see citing works

Induced pluripotent stem cells — opportunities for disease modelling and drug discovery

Grs̆ković, M., Javaherian, A., Strulovici, B., & Daley, G. Q. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3577 · Cited by 474 · see citing works

Diagnosing and treating Diamond Blackfan anaemia: results of an international clinical consensus conference

Vlachos, A., Ball, S. E., Dahl, N., Alter, B. P., Sheth, S., Ramenghi, U., Meerpohl, J. J., Karlsson, S., Liu, J. M., Leblanc, T. M., et al. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07269.x · Cited by 474 · see citing works

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

Weissmueller, S., Manchado, E., Saborowski, M., Morris, J. P., Wagenblast, E., Davis, C. A., Moon, S.-H., Pfister, N. T., Tschaharganeh, D. F., Kitzing, T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.066 · Cited by 466 · cited 1× · see citing works

The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease

Huang, S., Li, B., Gray, M. D., Oshima, J., Mian, S. I., & Campisi, J. (1998) · Nature Genetics · doi:10.1038/2410 · Cited by 453 · see citing works

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM

Song, H., Hollstein, M., & Xu, Y. (2007) · Nature Cell Biology · doi:10.1038/ncb1571 · Cited by 442 · see citing works

Excess of rare cancers in Werner syndrome (adult progeria).

Goto, M., Miller, R. W., Ishikawa, Y., & Sugano, H. (1996) · PubMed · Cited by 434 · see citing works

BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges

Chan, K., North, P. S., & Hickson, I. D. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601777 · Cited by 420 · see citing works

Ribosomal Protein L5 and L11 Mutations Are Associated with Cleft Palate and Abnormal Thumbs in Diamond-Blackfan Anemia Patients

Gazda, H. T., Sheen, M. R., Vlachos, A., Choesmel, V., O’Donohue, M.-F., Schneider, H. E., Darras, N., Hasman, C., Sieff, C. A., Newburger, P. E., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.11.004 · Cited by 417 · see citing works

p62 in Cancer: Signaling Adaptor Beyond Autophagy

Moscat, J., Karin, M., & Díaz-Meco, M. T. (2016) · Cell · doi:10.1016/j.cell.2016.09.030 · Cited by 392 · see citing works

Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation

Funato, K., Major, T., Lewis, P. W., Allis, C. D., & Tabar, V. (2014) · Science · doi:10.1126/science.1253799 · Cited by 390 · see citing works

The Pediatric Cancer Genome Project

Downing, J. R., Wilson, R. K., Zhang, J., Mardis, E. R., Pui, C., Ding, L., Ley, T. J., & Evans, W. E. (2012) · Nature Genetics · doi:10.1038/ng.2287 · Cited by 375 · see citing works

Osteosarcoma Development and Stem Cell Differentiation

Tang, N., Song, W., Luo, J., Haydon, R. C., & He, T. (2008) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-008-0335-z · Cited by 355 · see citing works

2009 Version of the Chompret Criteria for Li Fraumeni Syndrome

Tinat, J., Bougeard, G., Baert‐Desurmont, S., Vasseur, S., Martin, C., Bouvignies, E., Caron, O., Paillerets, B. B., Berthet, P., Dugast, C., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.7967 · Cited by 348 · see citing works

Paget disease of bone.

Roodman, G. D., & Windle, J. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24281 · Cited by 340 · see citing works

Association Between Osteosarcoma and Deleterious Mutations in the RECQL4 Gene in Rothmund-Thomson Syndrome

Wang, L. L., Gannavarapu, A., Kozinetz, C. A., Levy, M. L., Lewis, R. A., Chintagumpala, M. M., Ruiz-Maldanado, R., Contreras-Ruiz, J., Cunniff, C., Erickson, R. P., et al. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.9.669 · Cited by 338 · see citing works

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

Graña, X., Garriga, J., & Mayol, X. (1998) · Oncogene · doi:10.1038/sj.onc.1202575 · Cited by 328 · see citing works

Bloom's syndrome. XX. The first 100 cancers

GERMAN, J. L. (1997) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(96)00336-6 · Cited by 318 · see citing works

Clinical manifestations in a cohort of 41 Rothmund-Thomson syndrome patients

Wang, L. L., Levy, M. L., Lewis, R. A., Chintagumpala, M., Lev, D., Rogers, M., & Plon, S. E. (2001) · American Journal of Medical Genetics · doi:10.1002/1096-8628(20010722)102:1 · Cited by 316 · see citing works

Rb regulates fate choice and lineage commitment in vivo

Calo, E., Quintero-Estades, J. A., Danielian, P. S., Nedelcu, S., Berman, S. D., & Lees, J. A. (2010) · Nature · doi:10.1038/nature09264 · Cited by 313 · see citing works

Incidence of neoplasia in Diamond Blackfan anemia: a report from the Diamond Blackfan Anemia Registry

Vlachos, A., Rosenberg, P. S., Atsidaftos, E., Alter, B. P., & Lipton, J. M. (2012) · Blood · doi:10.1182/blood-2011-08-375972 · Cited by 309 · see citing works

Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.

Sangrithi, M. N., Bernal, J. A., Madine, M. A., Philpott, A., Lee, J.-K., Dunphy, W. G., & Venkitaraman, A. (2005) · Cell · doi:10.1016/j.cell.2005.05.015 · Cited by 305 · see citing works

Altered translation of GATA1 in Diamond-Blackfan anemia

Ludwig, L. S., Gazda, H. T., Eng, J. C., Eichhorn, S. W., Thiru, P., Ghazvinian, R., George, T. I., Gotlib, J. R., Beggs, A. H., Sieff, C. A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3557 · Cited by 302 · see citing works

Using Epidemiology and Genomics to Understand Osteosarcoma Etiology

Savage, S. A., & Mirabello, L. J. (2011) · Sarcoma · doi:10.1155/2011/548151 · Cited by 301 · see citing works

Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family

Danilova, N., Sakamoto, K. M., & Lin, S. L. (2008) · Blood · doi:10.1182/blood-2008-01-132290 · Cited by 291 · see citing works

Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis

Hanel, W. G., Marchenko, N. D., Xu, S., Yu, S., Weng, W., & Moll, U. M. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.17 · Cited by 278 · see citing works

Bloom's Syndrome: Clinical Spectrum, Molecular Pathogenesis, and Cancer Predisposition

Cunniff, C. M., Bassetti, J. A., & Ellis, N. A. (2016) · Molecular Syndromology · doi:10.1159/000452082 · Cited by 267 · see citing works

Osteoblast differentiation and skeletal development are regulated by Mdm2–p53 signaling

Lengner, C. J., Steinman, H. A., Gagnon, J. A., Smith, T. W., Henderson, J. E., Kream, B. E., Stein, G. S., Lian, J. B., & Jones, S. N. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508130 · Cited by 266 · see citing works

The Retinoblastoma-Histone Deacetylase 3 Complex Inhibits PPARγ and Adipocyte Differentiation

Lluis Fajas, A., Egler, V., Reiter, R. J., Hansen, J. B., Kristiansen, K., Debril, M.-B., Miard, S., & Auwerx, J. H. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00360-x · Cited by 258 · see citing works

K63 Polyubiquitination and Activation of mTOR by the p62-TRAF6 Complex in Nutrient-Activated Cells

Linares, J. F., Durán, Á., Yajima, T., Pasparakis, M., Moscat, J., & Díaz-Meco, M. T. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.06.020 · Cited by 256 · see citing works

Syndrome-causing mutations of theBLMgene in persons in the Bloom's Syndrome Registry

GERMAN, J. L., Sanz, M. M., Ciocci, S., Ye, T. Z., & Ellis, N. A. (2007) · Human Mutation · doi:10.1002/humu.20501 · Cited by 252 · see citing works

p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling

Wang, X., Kua, H.-Y., Hu, Y., Guo, K., Zeng, Q., Wu, Q., Ng, H., Karsenty, G., Crombrugghe, B. D., Yeh, J. K., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507106 · Cited by 250 · see citing works

CONGENITAL TELANGIECTATIC ERYTHEMA RESEMBLING LUPUS ERYTHEMATOSUS IN DWARFS Probably a Syndrome Entity

BLOOM, D. (1954) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1954.02050100756008 · Cited by 240 · see citing works

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

Moriarity, B. S., Otto, G. M., Rahrmann, E. P., Rathe, S. K., Wolf, N. K., Weg, M. T., Manlove, L. A., LaRue, R. S., Temiz, N. A., Molyneux, S. D., et al. (2015) · Nature Genetics · doi:10.1038/ng.3293 · Cited by 238 · see citing works

Spectrum and Risk of Neoplasia in Werner Syndrome: A Systematic Review

Lauper, J. M., Krause, A. J., Vaughan, T. L., & Monnat, R. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059709 · Cited by 234 · see citing works

The mutation spectrum in RECQL4 diseases

Siitonen, H. A., Sotkasiira, J., Biervliet, M., Benmansour, A., Capri, Y., Cormier‐Daire, V., Crandall, B. F., Hannula‐Jouppi, K., Hennekam, R. C. M., Herzog, D., et al. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.154 · Cited by 234 · see citing works

Patterns of ribosomal protein expression specify normal and malignant human cells

Guimaraes, J. C., & Zavolan, M. (2016) · Genome biology · doi:10.1186/s13059-016-1104-z · Cited by 233 · see citing works

The Etiology of Osteosarcoma

Ottaviani, G., & Jaffe, N. (2009) · Cancer treatment and research · doi:10.1007/978-1-4419-0284-9_2 · Cited by 232 · see citing works

Modeling Familial Cancer with Induced Pluripotent Stem Cells

Lee, D., Su, J., Kim, H. S., Chang, B., Papatsenko, D., Zhao, R., Yuan, Y., Gingold, J. A., Xia, W., Darr, H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.02.045 · Cited by 223 · see citing works

Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma

Toguchida, J., Ishizaki, K., Sasaki, M. S., Nakamura, Y., Ikenaga, M., Kato, M. V., Sugimot, M., Kotoura, Y., & Yamamuro, T. (1989) · Nature · doi:10.1038/338156a0 · Cited by 215 · see citing works

An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction

Macias, E., Jin, A., Deisenroth, C., Bhat, K., Mao, H., Lindström, M. S., & Zhang, Y. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.08.007 · Cited by 214 · see citing works

A common gain of function of p53 cancer mutants in inducing genetic instability

Liu, D., Song, H., & Xu, Y. (2009) · Oncogene · doi:10.1038/onc.2009.376 · Cited by 214 · see citing works

Osteosarcoma in Paget's Disease of Bone

Hansen, M. F., Seton, M., & Merchant, A. S. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.06s211 · Cited by 209 · see citing works

Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma

Thomas, D. M., Johnson, S. A. S., Sims, N. A., Trivett, M. K., Slavin, J., Rubin, B. P., Waring, P., McArthur, G. A., Walkley, C. R., Holloway, A. J., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200409187 · Cited by 208 · see citing works

Survival with retinoblastoma in the USA: 1975-2004

Broaddus, E., Topham, A., & Singh, A. D. (2008) · British Journal of Ophthalmology · doi:10.1136/bjo.2008.143842 · Cited by 200 · see citing works

Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases

Siitonen, H. A. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg306 · Cited by 196 · see citing works

The N-Terminal Noncatalytic Region of Xenopus RecQ4 Is Required for Chromatin Binding of DNA Polymerase α in the Initiation of DNA Replication

Matsuno, K., Kumano, M., Kubota, Y., Hashimoto, Y., & Takisawa, H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02267-05 · Cited by 194 · see citing works

Assembly of the Cdc45-Mcm2–7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins

Im, J., Ki, S.-H., Farina, A., Jung, D.-S., Hurwitz, J., & Lee, J.-K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908039106 · Cited by 185 · see citing works

Physical and Functional Interaction between p53 and the Werner's Syndrome Protein

Blander, G., Kipnis, J., Martínez-Leal, J. F., Yu, C., Schellenberg, G. D., & Oren, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.29463 · Cited by 181 · see citing works

Cytoplasmic and/or nuclear accumulation of the β‐catenin protein is a frequent event in human osteosarcoma

Haydon, R. C., Deyrup, A. T., Ishikawa, A., Heck, R. K., Jiang, W., Zhou, L., Feng, T., King, D., Cheng, H., Breyer, B. N., et al. (2002) · International Journal of Cancer · doi:10.1002/ijc.10719 · Cited by 171 · see citing works

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

Duan, S., Yuan, G., Liu, X., Ren, R., Li, J., Zhang, W., Wu, J., Xu, X., Fu, L., Li, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms10068 · Cited by 169 · see citing works

RB1 dual role in proliferation and apoptosis: Cell fate control and implications for cancer therapy

Indovina, P., Pentimalli, F., Casini, N., Vocca, I., & Giordano, A. (2015) · Oncotarget · doi:10.18632/oncotarget.4286 · Cited by 162 · see citing works

p53 is balancing development, differentiation and de-differentiation to assure cancer prevention

Molchadsky, A., Rivlin, N., Brosh, R., Rotter, V., & Sarig, R. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq101 · Cited by 156 · see citing works

Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome

Mann, M. B. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi075 · Cited by 156 · see citing works

Functional Interaction of p53 and BLM DNA Helicase in Apoptosis

Wang, X. W., Tseng, A., Ellis, N. A., Spillare, E. A., Linke, S. P., Robles, A. I., Seker, H., Yang, Q., Hu, P., Beresten, S. F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103298200 · Cited by 145 · see citing works

Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cellsPreprint

Pfister, N. T., Fomin, V., Regunath, K., Zhou, J. Y., Zhou, W., Silwal‐Pandit, L., Freed-Pastor, W. A., Laptenko, O., Neo, S. P., Bargonetti, J., et al. (2015) · Genes & Development · doi:10.1101/gad.263202.115 · Cited by 143 · see citing works

Modeling sarcomagenesis using multipotent mesenchymal stem cells

Rodrı́guez, R., Rubio, R., & Menéndez, P. R. (2011) · Cell Research · doi:10.1038/cr.2011.157 · Cited by 143 · see citing works

MCM10 mediates RECQ4 association with MCM2‐7 helicase complex during DNA replication

Xu, X., Rochette, P. J., Feyissa, E. A., Su, T., & Liu, Y. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.235 · Cited by 143 · see citing works

Cause-Specific Mortality in Long-Term Survivors of Retinoblastoma

Yu, C., Tucker, M. A., Abramson, D. H., Furukawa, K., Seddon, J. M., Stovall, M. A., Fraumeni, J. F., & Kleinerman, R. A. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp046 · Cited by 141 · see citing works

Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling

Lee, D., Su, J., Ang, Y.-S., Carvajal‐Vergara, X., Mulero‐Navarro, S., Pereira, C., Gingold, J. A., Wang, H.-L., Zhao, R., Sevilla, A., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.020 · Cited by 137 · see citing works

Notch Activation as a Driver of Osteogenic Sarcoma

Tao, J., Jiang, M., Jiang, L., Salvo, J. S., Zeng, H., Dawson, B., Bertin, T., Rao, P. H., Chen, R., Donehower, L. A., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.07.023 · Cited by 135 · see citing works

Osteogenic Sarcoma Associated With Diamond???Blackfan Anemia: A Report From the Diamond???Blackfan Anemia Registry

Lipton, J. M. M., Federman, N. C., Khabbaze, Y., Schwartz, C. L., Hilliard, L., Clark, J. I., & Vlachos, A. (2001) · The American journal of pediatric hematology/oncology · doi:10.1097/00043426-200101000-00009 · Cited by 132 · see citing works

Differential expression of genes coding for ribosomal proteins in different human tissues

Bortoluzzi, S., d’Alessi, F., Romualdi, C., & Danieli, G. A. (2001) · Bioinformatics · doi:10.1093/bioinformatics/17.12.1152 · Cited by 129 · see citing works

The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability

Petkovic, M., Dietschy, T., Freire, R., Jiao, R., & Štagljar, I. (2005) · Journal of Cell Science · doi:10.1242/jcs.02556 · Cited by 126 · see citing works

Incidence of second cancers after radiotherapy and systemic chemotherapy in heritable retinoblastoma survivors: A report from the German reference center

Ketteler, P., Arendt, M., Viehmann, A., Eisele, L., Guin, C. H. D. L., Schündeln, M. M., Biewald, E. M., Astrahantseff, K., Wieland, R., Bornfeld, N., et al. (2016) · Pediatric Blood & Cancer · doi:10.1002/pbc.26193 · Cited by 126 · see citing works

New Insights Into the Role of Sequestosome 1/p62 Mutant Proteins in the Pathogenesis of Paget's Disease of Bone

Rea, S. L., Walsh, J. P., Layfield, R., Ratajczak, T., & Xu, J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1034 · Cited by 123 · see citing works

The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types

Fancello, L., Kampen, K. R., Hofman, I. J., Verbeeck, J., & Keersmaecker, K. D. (2017) · Oncotarget · doi:10.18632/oncotarget.14895 · Cited by 123 · see citing works

The retinoblastoma tumor suppressor and stem cell biologyPreprint

Sage, J. (2012) · Genes & Development · doi:10.1101/gad.193730.112 · Cited by 119 · see citing works

The ribosomal protein S26 regulates p53 activity in response to DNA damage

Cui, D., Li, L., Lou, H., Sun, H., Ngai, S. H. O., Shao, G., & Tang, J. (2013) · Oncogene · doi:10.1038/onc.2013.170 · Cited by 119 · see citing works

Diverse diseases from a ubiquitous process: The ribosomopathy paradox

Armistead, J., & Triggs‐Raine, B. L. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.03.024 · Cited by 116 · see citing works

Vitamin C restores healthy aging in a mouse model for Werner syndrome

Massip, L., Garand, C., Paquet, É. R., Cogger, V. C., O'Reilly, J. N., Tworek, L., Hatherell, A., Taylor, C. G., Thorin, É., Zahradka, P. C., et al. (2009) · The FASEB Journal · doi:10.1096/fj.09-137133 · Cited by 114 · see citing works

Growth retardation and skin abnormalities of the Recql4-deficient mouse

Hoki, Y. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg254 · Cited by 114 · see citing works

Genomic Instability in Human Pluripotent Stem Cells Arises from Replicative Stress and Chromosome Condensation Defects

Lamm, N., Ben‐David, U., Golan‐Lev, T., Štorchová, Z., Benvenisty, N., & Kerem, B. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.11.003 · Cited by 110 · see citing works

Differential expression of S19 ribosomal protein, laminin-binding protein, and human lymphocyte antigen class I messenger RNAs associated with colon carcinoma progression and differentiation.

Kondoh, N., Schweinfest, C. W., Henderson, K. W., & Papas, T. S. (1992) · PubMed · Cited by 109 · see citing works

RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress

De, S., Kumari, J., Mudgal, R., Modi, P., Gupta, S., Futami, K., Goto, H., Lindor, N. M., Furuichi, Y., Mohanty, D., et al. (2012) · Journal of Cell Science · doi:10.1242/jcs.101501 · Cited by 107 · see citing works

Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors

Doulatov, S. R., Vo, L. T., Macari, E. R., Wahlster, L., Kinney, M. A., Taylor, A. M., Barragan, J., Gupta, M., McGrath, K. E., Lee, H., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah5645 · Cited by 105 · see citing works

Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging

Cheung, H.-H., Liu, X., Canterel-Thouennon, L., Li, L., Edmonson, C., & Rennert, O. M. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.02.006 · Cited by 102 · see citing works

WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects

Yokote, K., Chanprasert, S., Lee, L., Eirich, K., Takemoto, M., Watanabe, A., Koizumi, N., Lessel, D., Mori, T., Hisama, F. M., et al. (2016) · Human Mutation · doi:10.1002/humu.23128 · Cited by 100 · see citing works

Mesenchymal stem cell transformation and sarcoma genesis

Xiao, W., Mohseny, A. B., Hogendoorn, P. C. W., & Cleton-Jansen, A. (2013) · Clinical Sarcoma Research · doi:10.1186/2045-3329-3-10 · Cited by 99 · see citing works

RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

Lu, H., Shamanna, R. A., Keijzers, G., Anand, R., Rasmussen, L. J., Ćejka, P., Croteau, D. L., & Bohr, V. A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.079 · Cited by 95 · see citing works

Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients

Garçon, L., Ge, J., Manjunath, S. H., Mills, J. A., Apicella, M., Parikh, S. P., Sullivan, L. M., Podsakoff, G. M., Gadue, P. J., French, D. L., et al. (2013) · Blood · doi:10.1182/blood-2013-01-478321 · Cited by 92 · see citing works

The differentiation stage of p53-Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development

Rubio, R., Gutiérrez-Aranda, I., Sáez-Castillo, A. I., Labarga, A., Rosu‐Myles, M., González-García, S., Toribio, M. L., Menéndez, P. R., & Rodrı́guez, R. (2012) · Oncogene · doi:10.1038/onc.2012.507 · Cited by 91 · see citing works

Carrier Frequency of the Bloom SyndromeblmAshMutation in the Ashkenazi Jewish Population

Li, L., Eng, C. M., Desnick, R. J., GERMAN, J. L., & Ellis, N. A. (1998) · Molecular Genetics and Metabolism · doi:10.1006/mgme.1998.2733 · Cited by 88 · see citing works

Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations

Lorenz, S., Barøy, T., Sun, J., Nome, T., Vodák, D., Bryne, J. C., Håkelien, A.-M., Fernandez‐Cuesta, L., Möhlendick, B., Rieder, H., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6567 · Cited by 87 · see citing works

Direct and indirect roles of RECQL4 in modulating base excision repair capacity

Schurman, S. H., Hedayati, M. A., Wang, Z., Singh, D. K., Speina, E., Zhang, Y., Becker, K. G., Macris, M. A., Sung, P., Wilson, D. M., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp291 · Cited by 85 · see citing works

Epidemiology and Rb1 gene of retinoblastoma.

Yun, J., Li, Y., Xu, C.-T., & Pan, B.-R. (2011) · PubMed Central · doi:10.3980/j.issn.2222-3959.2011.01.24 · Cited by 84 · see citing works

Myeloid Dysregulation in a Human Induced Pluripotent Stem Cell Model of PTPN11-Associated Juvenile Myelomonocytic Leukemia

Mulero‐Navarro, S., Sevilla, A., Román, Á., Lee, D., D’Souza, S. L., Pardo, S., Riess, I., Su, J., Cohen, N., Schaniel, C., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.019 · Cited by 83 · see citing works

Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation of DNA helicases.

Ichikawa, K., Noda, T., & Furuichi, Y. (2002) · Folia Pharmacologica Japonica · doi:10.1254/fpj.119.219 · Cited by 82 · see citing works

Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases

Pinto, C., Kasaciunaite, K., Seidel, R., & Ćejka, P. (2016) · eLife · doi:10.7554/elife.18574 · Cited by 82 · see citing works

The Rb–E2F Transcriptional Regulatory Pathway in Tumor Angiogenesis and Metastasis

Schaal, C. M., Pillai, S., & Chellappan, S. (2014) · Advances in cancer research · doi:10.1016/b978-0-12-800249-0.00004-4 · Cited by 78 · see citing works

Vitamin C alleviates aging defects in a stem cell model for Werner syndrome

Li, Y., Zhang, W., Chang, L., Han, Y., Sun, L., Gong, X., Tang, H., Liu, Z., Deng, H., Ye, Y., et al. (2016) · Protein & Cell · doi:10.1007/s13238-016-0278-1 · Cited by 78 · see citing works

The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1

Markiewski, M. M., Vadrevu, S. K., Sharma, S., Chintala, N. K., Ghouse, S. M., Cho, J., Fairlie, D. P., Paterson, Y. Y. W., Astrinidis, A., & Karbowniczek, M. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1602057 · Cited by 78 · see citing works

Absence of the p53 tumor suppressor gene promotes osteogenesis in mesenchymal stem cells

Tataria, M., Quarto, N., Longaker, M. T., & Sylvester, K. G. (2006) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2005.12.001 · Cited by 76 · see citing works

The Evolution of the Ribosomal Protein–MDM2–p53 PathwayPreprint

Deisenroth, C., Franklin, D. A., & Zhang, Y. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026138 · Cited by 74 · see citing works

The p62 P392L Mutation Linked to Paget’s Disease Induces Activation of Human Osteoclasts

Chamoux, E., Couture, J., Bisson, M., Morissette, J., Brown, J. P., & Roux, S. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0066 · Cited by 73 · see citing works

RecQ4 Facilitates UV Light-induced DNA Damage Repair through Interaction with Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A (XPA)

Fan, W., & Luo, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801928200 · Cited by 72 · see citing works

Bloom’s syndrome: Why not premature aging?

de Renty, C., & Ellis, N. A. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.05.010 · Cited by 72 · see citing works

The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha

Wu, L. J. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf611 · Cited by 66 · see citing works

Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1 −/− mice

Gutierrez, G. M., Kong, E., Sabbagh, Y., Brown, N. E., Lee, J.-S., Demay, M. B., Thomas, D. M., & Hinds, P. W. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805925105 · Cited by 65 · see citing works

Radiographic Abnormalities in Rothmund-Thomson Syndrome and Genotype–Phenotype Correlation with RECQL4 Mutation Status

Mehollin-Ray, A. R., Kozinetz, C. A., Schlesinger, A. E., Guillerman, R. P., & Wang, L. L. (2008) · American Journal of Roentgenology · doi:10.2214/ajr.07.3619 · Cited by 65 · see citing works

Osteosarcoma: Pathology and classification

Unni, K. K., & Dahlin, D. C. (1989) · Seminars in Roentgenology · doi:10.1016/0037-198x(89)90010-2 · Cited by 64 · see citing works

Mice Expressing a Mammary Gland–Specific R270H Mutation in the p53 Tumor Suppressor Gene Mimic Human Breast Cancer Development

Wijnhoven, S., Zwart, E., Speksnijder, E. N., Beems, R. B., Olive, K. P., Tuveson, D. A., Jonkers, J., Schaap, M. M., van den Berg, J., Jacks, T., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1650 · Cited by 64 · see citing works

CDK1 phosphorylates WRN at collapsed replication forks

Palermo, V., Rinalducci, S., Sanchez, M., Grillini, F., Sommers, J. A., Brosh, R. M., Zolla, L., Franchitto, A., & Pichierri, P. (2016) · Nature Communications · doi:10.1038/ncomms12880 · Cited by 64 · see citing works

Reprogramming Suppresses Premature Senescence Phenotypes of Werner Syndrome Cells and Maintains Chromosomal Stability over Long-Term Culture

Shimamoto, A., Kagawa, H., Kazumasa, Z., Sera, Y., Kazuki, Y., Osaki, M., Oshimura, M., Ishigaki, Y., Hamasaki, K., Kodama, Y., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112900 · Cited by 63 · see citing works

Bloom's syndrome. VI. The disorder in Israel and an estimation of the gene frequency in the Ashkenazim.

German, J., Bloom, D., Passarge, E., Fried, K., Goodman, R. M., KATZENELLENBOGEN, I., Laron, Z., Legum, C., Levin, S., & Wahrman (1977) · Europe PMC (PubMed Central) · Cited by 62 · see citing works

RAPADILINO syndrome with radial and patellar aplasia/hypoplasia as main manifestations

Kääriäinen, H., Ryöppy, S., & Norio, R. (1989) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320330312 · Cited by 62 · see citing works

RECQL4 and p53 potentiate the activity of polymerase γ and maintain the integrity of the human mitochondrial genome

Gupta, S., De, S., Srivastava, V. K., Hussain, M., Kumari, J., Muniyappa, K., & Sengupta, S. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt315 · Cited by 62 · see citing works

P53 suppresses cell proliferation, metastasis, and angiogenesis of osteosarcoma through inhibition of the PI3K/AKT/mTOR pathway

Song, R., Tian, K., Wang, W., & Wang, L. (2015) · International Journal of Surgery · doi:10.1016/j.ijsu.2015.04.050 · Cited by 61 · see citing works

The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse

Quist, T. S., Jin, H., Zhu, J.-F., Smith-Fry, K., Capecchi, M. R., & Jones, K. B. (2014) · Oncogene · doi:10.1038/onc.2014.354 · Cited by 58 · see citing works

RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex

Shamanna, R. A., Singh, D. K., Lu, H., Mirey, G., Keijzers, G., Salles, B., Croteau, D. L., & Bohr, V. A. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu137 · Cited by 58 · see citing works

Sit down, relax and unwind: structural insights into RecQ helicase mechanisms

Killoran, M. P., & Keck, J. L. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl538 · Cited by 57 · see citing works

Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis

Rey, M. A., Duffy, S. P., Brown, J. K., Kennedy, J. A., Dick, J. E., Dror, Y., & Tailor, C. S. (2008) · Haematologica · doi:10.3324/haematol.13359 · Cited by 56 · see citing works

Aging in Rothmund-Thomson syndrome and related RECQL4 genetic disorders

Lu, L., Jin, W., & Wang, L. L. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.06.002 · Cited by 52 · see citing works

Ribosomal protein S19 and S24 insufficiency cause distinct cell cycle defects in Diamond–Blackfan anemia

Badhai, J., Fröjmark, A.-S., Davey, E. J., Schuster, J., & Dahl, N. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.08.002 · Cited by 48 · see citing works

Generation of Osteosarcomas from a Combination of Rb Silencing and c-Myc Overexpression in Human Mesenchymal Stem Cells

Wang, J., Wu, P., Chen, P. C.-H., Lee, C.-W., Chen, W., & Hung, S. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0226 · Cited by 48 · see citing works

Lessons from Retinoblastoma: Implications for Cancer, Development, Evolution, and Regenerative Medicine

Dyer, M. A. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.07.010 · Cited by 46 · see citing works

RECQ DNA Helicases and Osteosarcoma

Lu, L., Jin, W., Liu, H., & Wang, L. L. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-04843-7_7 · Cited by 45 · see citing works

The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation

Ng, A. J., Walia, M., Smeets, M. F. M. A., Mutsaers, A. J., Sims, N. A., Purton, L. E., Walsh, N. C., Martin, T. J., & Walkley, C. R. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005160 · Cited by 45 · see citing works

Diamond-Blackfan anemia: a ribosomal puzzle

Dianzani, I., & Loreni, F. (2008) · Haematologica · doi:10.3324/haematol.2008.000513 · Cited by 45 · see citing works

Absence of RECQL4 mutations in poikiloderma with neutropenia in Navajo and non‐Navajo patients

Wang, L. L., Gannavarapu, A., Clericuzio, C. L., Erickson, R. P., Irvine, A. D., & Plon, S. E. (2003) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.10057 · Cited by 39 · see citing works

RECQL4 Regulates p53 Function In Vivo During Skeletogenesis

Lu, L., Harutyunyan, K. G., Jin, W., Wu, J., Yang, T., Chen, Y., Joeng, K. S., Bae, Y., Tao, J., Dawson, B., et al. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2436 · Cited by 38 · see citing works

Osteocytes Serve as a Progenitor Cell of Osteosarcoma

Sottnik, J. L., Campbell, B., Mehra, R., Behbahani‐Nejad, O., Hall, C. L., & Keller, E. T. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24793 · Cited by 37 · see citing works

Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells

Kliszczak, M., Polášek-Sedláčková, H., Pitchai, G. P., Streicher, W. W., Krejčí, L., & Hickson, I. D. (2015) · Oncotarget · doi:10.18632/oncotarget.6342 · Cited by 37 · see citing works

A model for the phenotypic presentation of Werner's syndrome

Ostler, E. L., Wallis, C. V., Sheerin, A. N. P., & Faragher, R. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00194-2 · Cited by 35 · see citing works

Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome

Bagley, M. C., Davis, T., Murziani, P. G. S., Widdowson, C. S., & Kipling, D. (2010) · Pharmaceuticals · doi:10.3390/ph3061842 · Cited by 35 · see citing works

Modeling Cancer with Pluripotent Stem Cells

Gingold, J. A., Zhou, R., Lemischka, I. R., & Lee, D. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.07.007 · Cited by 35 · see citing works

Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma

Yang, J., Annala, M., Ji, P., Wang, G., Zheng, H., Codgell, D., Du, X., Fang, Z., Sun, B., Nykter, M., et al. (2014) · Journal of Hematology & Oncology · doi:10.1186/s13045-014-0076-2 · Cited by 33 · see citing works

The histogenesis of Ewing Sarcoma

Tu, J., Huo, Z., Gingold, J. A., Zhao, R., Shen, J., & Lee, D. (2017) · Cancer Reports and Reviews · doi:10.15761/crr.1000111 · Cited by 31 · see citing works

Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span

Dallaire, A., Proulx, S., Simard, M. J., & Lebel, M. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-940 · Cited by 28 · see citing works

Class I Histone Deacetylase HDAC1 and WRN RECQ Helicase Contribute Additively to Protect Replication Forks upon Hydroxyurea-induced Arrest

Kehrli, K., Phelps, M., Lazarchuk, P., Chen, E. Y., Monnat, R., & Sidorova, J. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.708594 · Cited by 27 · see citing works

BLM promotes the activation of Fanconi Anemia signaling pathway

Panneerselvam, J., Wang, H., Zhang, J., Che, R., Yu, H., & Fei, P. (2016) · Oncotarget · doi:10.18632/oncotarget.8707 · Cited by 26 · see citing works

Paget’s disease of bone: an osteoimmunological disorder?

Michou, L., Numan, M., Amiable, N., & Brown, J. P. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s88845 · Cited by 23 · see citing works

Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts

Davis, T., Brook, A. C., Rokicki, M., Bagley, M. C., & Kipling, D. (2016) · Pharmaceuticals · doi:10.3390/ph9020023 · Cited by 23 · see citing works

Molecular Biology of Sarcomas

Gebhardt, M. C. (1996) · Orthopedic Clinics of North America · doi:10.1016/s0030-5898(20)32089-7 · Cited by 21 · see citing works

Targeted inhibition of WRN helicase, replication stress and cancer

Orlovetskie, N., Serruya, R., Abboud-Jarrous, G., & Jarrous, N. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.11.004 · Cited by 18 · see citing works

Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase

Aumailley, L., Dubois, M. J., Garand, C., Marette, A., & Lebel, M. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.10.012 · Cited by 16 · see citing works

A novel TP53-KPNA3 translocation defines a de novo treatment-resistant clone in osteosarcomaPreprint

Chen, K. S.-M., Kwon, W. S., Kim, J., Heo, S. J., Kim, H. S., Kim, H. K., Kim, S. H., Lee, W. S., Chung, H. C., Rha, S. Y., et al. (2016) · Molecular Case Studies · doi:10.1101/mcs.a000992 · Cited by 16 · see citing works

On BLM helicase in recombination-mediated telomere maintenance

Rezazadeh, S. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-2379-0 · Cited by 13 · see citing works

Generation of induced pluripotent stem cells (iPSCs) from a retinoblastoma patient carrying a c.2663G > A mutation in RB1 gene

Zeng, S., Liu, L., Ouyang, Q., Zhao, Y. D., Lin, G., Hu, L., & Li, W. (2016) · Stem Cell Research · doi:10.1016/j.scr.2016.08.015 · Cited by 9 · see citing works

Osteosarcoma

Beird, H. C., Bielack, S. S., Flanagan, A. M., Gill, J., Heymann, D., Janeway, K. A., Livingston, J. A., Roberts, R. D., Strauss, S. J., & Gorlick, R. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00409-y · Cited by 660 · see citing works

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

Chehelgerdi, M., Dehkordi, F. B., Chehelgerdi, M., Kabiri, H., Salehian-Dehkordi, H., Abdolvand, M. A., Salmanizadeh, S., Rashidi, M., Niazmand, A., Ahmadi, S., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01873-0 · Cited by 184 · see citing works

Long non-coding RNA PVT1 encapsulated in bone marrow mesenchymal stem cell-derived exosomes promotes osteosarcoma growth and metastasis by stabilizing ERG and sponging miR-183-5p

Zhao, W., Qin, P., Zhang, D., Cui, X., Gao, J., Yu, Z., Chai, Y., Wang, J., & Li, J. (2019) · Aging · doi:10.18632/aging.102406 · Cited by 115 · see citing works

Molecular mechanisms underpinning sarcomas and implications for current and future therapy

Damerell, V., Pepper, M. S., & Prince, S. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00647-8 · Cited by 114 · see citing works

KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma

Jiang, Y., Li, F., Gao, B., Ma, M., Chen, M., Wu, Y., Zhang, W., Sun, Y., Liu, S., & Shen, H. (2021) · Theranostics · doi:10.7150/thno.53347 · Cited by 91 · see citing works

Hereditary cancer syndromes

Имянитов, Е. Н., Kuligina, E. S., Соколенко, А. П., Suspitsin, E. N., Yanus, G. A., Iyevleva, A. G., Ivantsov, A. O., & Алексахина, С. Н. (2023) · World Journal of Clinical Oncology · doi:10.5306/wjco.v14.i2.40 · Cited by 79 · see citing works

Nanoparticles and bone microenvironment: a comprehensive review for malignant bone tumor diagnosis and treatment

Guan, Y., Zhang, W., Mao, Y., & Li, S. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02161-1 · Cited by 85 · see citing works

LncRNA, CRNDE promotes osteosarcoma cell proliferation, invasion and migration by regulating Notch1 signaling and epithelial-mesenchymal transition

Li, Z., Tang, Y., Xing, W., Dong, W., & Wang, Z. (2017) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2017.12.002 · Cited by 75 · see citing works

MicroRNA-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4

Xu, Z., Chen, L., Wang, C., Zhang, L., & Xu, W. (2021) · Free Radical Research · doi:10.1080/10715762.2021.2024816 · Cited by 71 · see citing works

Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice

Lee, S. Y., Park, K. H., Yu, H.-G., Kook, E., Song, W., Lee, G., Koh, J., Shin, H., Choi, J., Huh, Y. H., et al. (2019) · Bone Research · doi:10.1038/s41413-019-0054-y · Cited by 63 · see citing works

Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis

Homayoonfal, M., Asemi, Z., & Yousefi, B. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00320-0 · Cited by 64 · see citing works

Emerging roles of non-coding RNAs in the pathogenesis, diagnosis and prognosis of osteosarcoma

Wang, C., Jing, J., & Cheng, L. (2018) · Investigational New Drugs · doi:10.1007/s10637-018-0624-7 · Cited by 61 · see citing works

Oncogenic role of SFRP2 in p53-mutant osteosarcoma development via autocrine and paracrine mechanism

Kim, H., Yoo, S., Zhou, R., Xu, A., Bernitz, J. M., Yuan, Y., Gomes, A., Daniel, M. G., Su, J., Demicco, E. G., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1814044115 · Cited by 58 · see citing works

Extracellular vesicles from osteosarcoma cell lines contain miRNAs associated with cell adhesion and apoptosis

Jerez, S., Araya, H., Hevia, D., Irarrázaval, C. E., Thaler, R., van Wijnen, A. J., & Galindo, M. A. (2019) · Gene · doi:10.1016/j.gene.2019.06.005 · Cited by 58 · see citing works

CircRNA–miRNA networks in regulating bone disease

Huang, W., Wu, Y., Qiao, M., Xie, Z., Cen, X. B., Huang, X., & Zhao, Z. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30625 · Cited by 56 · see citing works

Li–Fraumeni Syndrome Disease Model: A Platform to Develop Precision Cancer Therapy Targeting Oncogenic p53

Zhou, R., Xu, A., Gingold, J. A., Strong, L. C., Zhao, R., & Lee, D. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.07.004 · Cited by 52 · see citing works

Nanoengineering a metal–organic framework for osteosarcoma chemo-immunotherapy by modulating indoleamine-2,3-dioxygenase and myeloid-derived suppressor cells

Fan, Q., Zuo, J., Tian, H., Huang, C., Nice, E. C., Shi, Z., & Kong, Q. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02372-8 · Cited by 51 · see citing works

FOXP1 drives osteosarcoma development by repressing P21 and RB transcription downstream of P53

Li, H., Han, X., Yang, S., Wang, Y., Dong, Y., & Tang, T. (2021) · Oncogene · doi:10.1038/s41388-021-01742-4 · Cited by 48 · see citing works

Design strategies and evolving role of biomaterial assisted treatment of osteosarcoma

Quadros, M., Momin, M. M., & Verma, G. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.111875 · Cited by 47 · see citing works

Circular RNAs hsa_circ_0032462, hsa_circ_0028173, hsa_circ_0005909 are predicted to promote CADM1 expression by functioning as miRNAs sponge in human osteosarcoma

Chen, G., Wang, Q., Yang, Q., Li, Z., Du, Z., Ren, M., Zhao, H., Song, Y., & Zhang, G. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202896 · Cited by 45 · see citing works

Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA‐424 in osteosarcoma

Hu, Y., Gu, J., Shen, H., Shao, T., Li, S., Wang, W., & Yu, Z. (2019) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23045 · Cited by 44 · see citing works

The multiple function of long noncoding RNAs in osteosarcoma progression, drug resistance and prognosis

Xu, S., Gong, Y., Yin, Y., Xing, H., & Zhang, N. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110141 · Cited by 40 · see citing works

MAFG-driven osteosarcoma cell progression is inhibited by a novel miRNA miR-4660

Shan, H., Zhu, L., Yao, C., Zhang, Z.-Q., Liu, Y.-Y., Jiang, Q. L., Zhou, X., Wang, X., & Cao, C. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.03.006 · Cited by 38 · see citing works

Patient-derived induced pluripotent stem cells for models of cancer and cancer stem cell research

Chao, H., & Chern, E. (2018) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2018.06.013 · Cited by 37 · see citing works

Osteosarcoma tumor microenvironment: the key for the successful development of biologically relevant 3D in vitro models

Rodrigues, J., Sarmento, B. F. C. C., & Pereira, C. L. (2022) · In vitro models · doi:10.1007/s44164-022-00008-x · Cited by 39 · see citing works

CDH4 is a novel determinant of osteosarcoma tumorigenesis and metastasis

Tang, Q., Lu, J., Zou, C., Shao, Y. W., Chen, Y., Narala, S., Fang, H., Xu, H., Wang, J., Shen, J., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0231-2 · Cited by 34 · see citing works

Exosomal transfer of miR-769-5p promotes osteosarcoma proliferation and metastasis by targeting DUSP16

Liu, W., Wang, B., Duan, A., Shen, K., Zhang, Q., Tang, X., Wei, Y., Tang, J. X., & Zhang, S. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02257-4 · Cited by 34 · see citing works

Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies

Tu, J., Huo, Z., Yu, Y., Zhu, D., Xu, A., Huang, M.-F., Hu, R., Wang, R., Gingold, J. A., Chen, Y., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2117857119 · Cited by 33 · see citing works

LncRNA TUG1 promotes the development of osteosarcoma through RUNX2

Sheng, K., & Li, Y. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7880 · Cited by 32 · see citing works

Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/β-catenin signal pathway

-, L. S., Ma, D., & Cuili, C. (2020) · Aging · doi:10.18632/aging.103546 · Cited by 32 · see citing works

Identification of Gαi3 as a promising target for osteosarcoma treatment

Bian, Z.-J., Shan, H., Zhu, Y.-R., Shi, C., Chen, M., Huang, Y., Wang, X.-D., Zhou, X., & Cao, C. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.68861 · Cited by 32 · see citing works

Multifunctional nanoparticles for the treatment and diagnosis of osteosarcoma

Yuan, P., Min, Y., & Zhao, Z. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213466 · Cited by 31 · see citing works

ROCK2 promotes osteosarcoma growth and metastasis by modifying PFKFB3 ubiquitination and degradation

Deng, X., Yi, X., Deng, J., Zou, Y., Wang, S., Shan, W., Liu, P., Zhang, Z., Chen, L., & Hao, L. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.111689 · Cited by 30 · see citing works

Key genes with prognostic values in suppression of osteosarcoma metastasis using comprehensive analysis

Li, M., Jin, X., Li, H., Wu, G., Wang, S., Yang, C., & Deng, S. (2020) · BMC Cancer · doi:10.1186/s12885-020-6542-z · Cited by 29 · see citing works

LncRNA H19 Suppresses Osteosarcomagenesis by Regulating snoRNAs and DNA Repair Protein Complexes

Xu, A., Huang, M.-F., Zhu, D., Gingold, J. A., Bazer, D. A., Chang, B., Wang, D., Lai, C., Lemischka, I. R., Zhao, R., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.611823 · Cited by 28 · see citing works

A Novel Six Metastasis-Related Prognostic Gene Signature for Patients With Osteosarcoma

Zheng, D., Xia, K., Yu, L., Gong, C., Shi, Y., Li, W., Qiu, Y., Yang, J. M., & Guo, W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.699212 · Cited by 27 · see citing works

B7-H3 in Pediatric Tumors: Far beyond Neuroblastoma

Bottino, C., Vitale, C., Dondero, A., & Castriconi, R. (2023) · Cancers · doi:10.3390/cancers15133279 · Cited by 28 · see citing works

Hsa_circ_0008934 promotes the proliferation and migration of osteosarcoma cells by targeting miR-145-5p to enhance E2F3 expression

Li, S., Zeng, M., Yang, L., Tan, J., Yang, J., Guan, H., Kuang, M., & Li, J. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105826 · Cited by 27 · see citing works

Multifunctional 3D-printed bioceramic scaffolds: Recent strategies for osteosarcoma treatment

Liu, X., Liu, Y., Qiang, L., Ya, R., Lin, Y., Li, H., Chen, Q., Gao, S., Yang, X., Zhang, C., et al. (2023) · Journal of Tissue Engineering · doi:10.1177/20417314231170371 · Cited by 28 · see citing works

Tumor-microenvironment-responsive poly-prodrug encapsulated semiconducting polymer nanosystem for phototherapy-boosted chemotherapy

Zhu, J., Zhang, Y., Li, Z., Bao, X., Zhou, Y., Ma, B., Xie, Y., Yan, P., Wu, Z., Zhang, Q., et al. (2023) · Materials Horizons · doi:10.1039/d3mh00242j · Cited by 26 · see citing works

Advances in the Application of Exosomes Identification Using Surface-Enhanced Raman Spectroscopy for the Early Detection of Cancers

Yang, L. G., Jia, J., & Li, S. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.808933 · Cited by 24 · see citing works

The role of m6A methylation in osteosarcoma biological processes and its potential clinical value

Wu, Y., Wang, Z., Shen, J., Yan, W., Xiang, S., Liu, H., & Huang, W. (2022) · Human Genomics · doi:10.1186/s40246-022-00384-1 · Cited by 24 · see citing works

The interaction between osteosarcoma and other cells in the bone microenvironment: From mechanism to clinical applications

Zeng, J., Peng, Y., Wang, D., Ayesha, K., & Chen, S. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1123065 · Cited by 25 · see citing works

Human umbilical vein endothelial cells derived-exosomes promote osteosarcoma cell stemness by activating Notch signaling pathway

Yang, J., Hu, Y., Wang, L., Sun, X., Yu, L., & Guo, W. (2021) · Bioengineered · doi:10.1080/21655979.2021.2005220 · Cited by 22 · see citing works

Prognostic Factors in Patients With Osteosarcoma With the Surveillance, Epidemiology, and End Results Database

Fu, P., Shi, Y., Chen, G., Fan, Y., Gu, Y., & Gao, Z. (2020) · Technology in Cancer Research & Treatment · doi:10.1177/1533033820947701 · Cited by 22 · see citing works

The potential roles of exosomal noncoding RNAs in osteosarcoma

Li, S., & Wang, X. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30101 · Cited by 22 · see citing works

Modeling cancer progression using human pluripotent stem cell-derived cells and organoids

Zhang, M., Vandana, J. J., Lacko, L. A., & Chen, S. (2020) · Stem Cell Research · doi:10.1016/j.scr.2020.102063 · Cited by 22 · see citing works

Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome

Jewell, B. E., Xu, A., Zhu, D., Huang, M.-F., Lu, L., Liu, M., Underwood, E. L., Park, J. H., Fan, H., Gingold, J. A., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009971 · Cited by 19 · see citing works

Osteosarcoma Multi-Omics Landscape and Subtypes

Tang, S., Roberts, R. D., Cheng, L., & Li, L. (2023) · Cancers · doi:10.3390/cancers15204970 · Cited by 19 · see citing works

Translational cell biology of highly malignant osteosarcoma

Roessner, A., Lohmann, C. H., & Jechorek, D. (2021) · Pathology International · doi:10.1111/pin.13080 · Cited by 20 · see citing works

Geranylgeranylacetone promotes human osteosarcoma cell apoptosis by inducing the degradation of PRMT1 through the E3 ubiquitin ligase CHIP

Jiang, L., Liao, J., Liu, J., Wei, Q., & Wang, Y. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16725 · Cited by 19 · see citing works

Osteocytes and Cancer

Pin, F., Prideaux, M., Bonewald, L. F., & Bonetto, A. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-021-00712-9 · Cited by 19 · see citing works

LncRNA GAS5 Regulates Osteosarcoma Cell Proliferation, Migration, and Invasion by Regulating RHOB via Sponging miR-663a

Yao, X., Li, X., Luo, Y., Xu, X., Liu, J., & Bu, J. (2020) · Cancer Management and Research · doi:10.2147/cmar.s251881 · Cited by 17 · see citing works

The Emerging Role of Extracellular Vesicle-Derived lncRNAs and circRNAs in Tumor and Mesenchymal Stem Cells: The Biological Functions and Potential for Clinical Application

Luo, Y., Liu, C., Kirby, J. A., Chu, C., Zang, D., & Chen, J. (2025) · Cancers · doi:10.3390/cancers17132186 · Cited by 15 · see citing works

SND1 promotes the proliferation of osteosarcoma cells by upregulating COX‑2/PGE2 expression via activation of NF‑κB

Zhou, M. D., Wang, A., Yin, B., Wu, D., Han, S., Zhang, W., Liu, J., & Sun, K. (2018) · Oncology Reports · doi:10.3892/or.2018.6822 · Cited by 15 · see citing works

Orai1 Promotes Osteosarcoma Metastasis by Activating the Ras-Rac1-WAVE2 Signaling Pathway

Guo, Y., Zhu, J., Wang, X., Li, R., Jiang, K., Chen, S., Fan, J., Xue, L., & Hao, D. (2019) · Medical Science Monitor · doi:10.12659/msm.919594 · Cited by 15 · see citing works

LncRNA SNHG10 increases the methylation of miR-218 gene to promote glucose uptake and cell proliferation in osteosarcoma

He, P., Xu, Y., & Wang, Z. (2020) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-020-01865-6 · Cited by 15 · see citing works

Identification of a Solute Carrier Family-Based Signature for Predicting Overall Survival in Osteosarcoma

Zheng, D., Wei, Z., & Guo, W. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.849789 · Cited by 15 · see citing works

Exosomes in osteosarcoma research and preclinical practice.

Zhang, X., Zhang, R., Su, X., Qi, J., Hu, Y., Shi, J.-T., Zhang, K., Wang, K.-P., & Zhou, H.-Y. (2021) · PubMed Central · Cited by 15 · see citing works

Differential Expression of Non-Coding RNAs in Stem Cell Development and Therapeutics of Bone Disorders

Mishra, A., Kumar, R., Mishra, S. N., Vijayaraghavalu, S., Tiwari, N. K., Shukla, G. C., Gurusamy, N., & Kumar, M. (2023) · Cells · doi:10.3390/cells12081159 · Cited by 14 · see citing works

Novel agent DMAMCL suppresses osteosarcoma growth and decreases the stemness of osteosarcoma stem cell

Ba, G., Hua, Z., Xu, N., Zhang, S., Liu, Z., Thiele, C. J., & Li, Z. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1762041 · Cited by 16 · see citing works

Construction of a cuproptosis‐related lncRNA signature for predicting prognosis and immune landscape in osteosarcoma patients

Ni, S., Hong, J., Li, W., Ye, M., & Li, J. (2022) · Cancer Medicine · doi:10.1002/cam4.5214 · Cited by 14 · see citing works

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Zhou, R., Xu, A., Tu, J., Liu, M., Gingold, J. A., Zhao, R., & Lee, D. (2018) · Journal of Visualized Experiments · doi:10.3791/57664 · Cited by 16 · see citing works

lncRNA HCG11 suppresses human osteosarcoma growth through upregulating p27 Kip1

Gu, J., Dai, B., Shi, X., He, Z., Xu, Y., Meng, X., & Zhu, J. (2021) · Aging · doi:10.18632/aging.203517 · Cited by 13 · see citing works

Generation of human embryonic stem cell line with heterozygous RB1 deletion by CRIPSR/Cas9 nickase

Tu, J., Huo, Z., Liu, M., Wang, D., Xu, A., Zhou, R., Zhu, D., Gingold, J. A., Shen, J., Zhao, R., et al. (2018) · Stem Cell Research · doi:10.1016/j.scr.2018.01.021 · Cited by 13 · see citing works

Induced Pluripotent Stem Cells and Induced Pluripotent Cancer Cells in Cancer Disease Modeling

Zhu, D., Kong, C. S. L., Gingold, J. A., Zhao, R., & Lee, D. (2018) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_257 · Cited by 13 · see citing works

von Willebrand factor rescued by miR-24 inhibition facilitates the proliferation and migration of osteosarcoma cells in vitro

Liu, L., Pan, J., Wang, H., Ma, Z., Yin, J., Yuan, F., Yuan, Q., Zhou, L., Liu, X., Zhang, Y., et al. (2018) · Bioscience Reports · doi:10.1042/bsr20180372 · Cited by 13 · see citing works

Cancer in a dish: progress using stem cells as a platform for cancer research.

Liu, M., Tu, J., Gingold, J. A., Kong, C. S. L., & Lee, D. (2018) · Europe PMC (PubMed Central) · Cited by 13 · see citing works

Circular RNAs in osteosarcoma: An update of recent studies (Review)

Zeng, L., Liu, L., Ni, W.-J., Xie, F., & Leng, X.-M. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5571 · Cited by 12 · see citing works

DLX2 promotes osteosarcoma epithelial-mesenchymal transition and doxorubicin resistance by enhancing HOXC8-CDH2 axis

Zhang, B., Du, X., Fan, Y., Qu, G., Pang, L. K., Zhao, R., & Yao, W. (2023) · iScience · doi:10.1016/j.isci.2023.108272 · Cited by 12 · see citing works

From biology to personalized medicine: Recent knowledge in osteosarcoma

Mohr, A., Costa, M. E. M. D., Fromigué, O., Audinot, B., Balde, T., Droit, R., Abbou, S. D., Khneisser, P., Berlanga, P., Pérez, E., et al. (2024) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2024.104941 · Cited by 13 · see citing works

Current insight into a cancer-implicated long noncoding RNA ZFAS1 and correlative functional mechanisms involved

Li, Z., Jiang, X., Su, Z., Li, J., Kang, P., Li, C., & Cui, Y. (2018) · Pathology - Research and Practice · doi:10.1016/j.prp.2018.07.032 · Cited by 12 · see citing works

Fraxinellone Has Anticancer Activity by Inducing Osteosarcoma Cell Apoptosis via Promoting Excessive Autophagy Flux

He, B., Zhang, W., & He, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.653212 · Cited by 12 · see citing works

PDK1-dependent metabolic reprogramming regulates stemness and tumorigenicity of osteosarcoma stem cells through ATF3

Tokumura, K., Fukasawa, K., Ichikawa, J., Sadamori, K., Hiraiwa, M., & Hinoi, E. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07903-7 · Cited by 12 · see citing works

Calycosin induces apoptosis in osteosarcoma cell line via ERβ‑mediated PI3K/Akt signaling pathways

Tian, W., Wang, Z., Yuan, B., & Bao, Y. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11039 · Cited by 11 · see citing works

Marsdenia tenacissima extract accelerates ferroptosis of osteosarcoma cells by upregulating HO-1 and activating mitophagy

Xiang, D., Zhang, X., Xue, X., Liang, H., Meng, J., Zhao, S., Yang, J., Zhou, Y., Hu, Y., Xu, L., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120055 · Cited by 10 · see citing works

Computational tools for analyzing single-cell data in pluripotent cell differentiation studies

Ding, J., Alavi, A., Ebrahimkhani, M. R., & Bar‐Joseph, Z. (2021) · Cell Reports Methods · doi:10.1016/j.crmeth.2021.100087 · Cited by 10 · see citing works

Long Non-Coding RNAs as Competitive Endogenous RNAs in Osteosarcoma

Кушлинский, Н. Е., Fridman, M. V., & Александровна, Б. Э. (2020) · Molecular Biology · doi:10.1134/s0026893320050052 · Cited by 10 · see citing works

Cell Differentiation Trajectory-Associated Molecular Classification of Osteosarcoma

Xu, A., Qian, C., Lin, J., Yu, W., Jin, J., Liu, B., & Tao, H. (2021) · Genes · doi:10.3390/genes12111685 · Cited by 10 · see citing works

ZCCHC12 promotes the progression of osteosarcoma via PI3K/AKT pathway

Cui, Y., & Dong, Y.-Y. (2022) · Aging · doi:10.18632/aging.204296 · Cited by 10 · see citing works

ADAMTS7 degrades Comp to fuel BMP2‐dependent osteogenic differentiation and ameliorate oncogenic potential in osteosarcomas

Wang, C., Chen, Y., Xiang, H., Wu, X., Tang, Q., Ma, X., & Zhang, L. (2020) · FEBS Open Bio · doi:10.1002/2211-5463.12939 · Cited by 10 · see citing works

Circ_0000885 Enhances Osteosarcoma Progression by Increasing FGFR1 Expression via Sponging MiR-1294

Chen, Y., Zhang, S., Bai, C., Guan, Z., & Chen, W. (2020) · Cancer Management and Research · doi:10.2147/cmar.s244382 · Cited by 9 · see citing works

MiRNA-218 inhibits cell proliferation, migration and invasion by targeting Runt-related transcription factor 2 (Runx2) in human osteosarcoma cells

Guo, Q., Ma, J., & Wu, J. (2021) · Regenerative Therapy · doi:10.1016/j.reth.2021.11.003 · Cited by 9 · see citing works

LINC00665 Facilitates the Malignant Processes of Osteosarcoma by Increasing the RAP1B Expression via Sponging miR-708 and miR-142-5p

Wang, L., Song, X., Li-jun, Y., Liu, B., Ma, J., & Yang, W. (2021) · Analytical Cellular Pathology · doi:10.1155/2021/5525711 · Cited by 8 · see citing works

Role of ceramides in diabetic foot ulcers (Review)

Wang, Y., Sun, Z., Zang, G., Zhang, L., & Wang, Z. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5229 · Cited by 8 · see citing works

Establishment of a prognostic risk model for osteosarcoma and mechanistic investigation

Jiang, H., Zhao, X., Zang, J., Wang, R., Gao, J., Chen, J., & Yu, T. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1399625 · Cited by 8 · see citing works

Modeling of osteosarcoma with induced pluripotent stem cells

Pang, L. K., Pena, M., Zhao, R., & Lee, D. (2020) · Stem Cell Research · doi:10.1016/j.scr.2020.102006 · Cited by 8 · see citing works

ING5 is a Potential Target for Osteosarcoma Therapy

Zhang, X., Xu, Z., Xie, H., Sun, Y., Liu, J., & Zhao, Y.-B. (2018) · Technology in Cancer Research & Treatment · doi:10.1177/1533033818762680 · Cited by 8 · see citing works

In Silico Modeling of the Induction of Apoptosis by Cryptotanshinone in Osteosarcoma Cell Lines

Saraf, R., Datta, A. A., Chao Sima, A., Jianping Hua, A., Lopes, R., Bittner, M. L., Miller, T. M., & Wilson-Robles, H. M. (2020) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2020.3037318 · Cited by 8 · see citing works

MiR-129-5p Suppresses Cell Proliferation of Human Osteosarcoma Cancer by Down-Regulating LncRNA Lnc712

Yu, Y., Zuo, W., Cai, W., Xu, Y., Liu, W., & Zhao, Z. (2021) · Cancer Management and Research · doi:10.2147/cmar.s284078 · Cited by 7 · see citing works

PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective

Sun, C., & Li, S. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16420 · Cited by 7 · see citing works

Nanoparticle-driven reactive oxygen species therapy: A new frontier in osteosarcoma treatment

He, L., Habibović, P., & van Rijt, S. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114289 · Cited by 6 · see citing works

circKMT2D contributes to H2O2‑attenuated osteosarcoma progression via the miR‑210/autophagy pathway

Zhang, J., Chou, X., Zhuang, M., Zhu, C., Hu, Y., Cheng, D., & Liu, Z. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9193 · Cited by 6 · see citing works

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Zhou, R., Xu, A., Tu, J., Liu, M., Gingold, J. A., Zhao, R., & Lee, D. (2018) · Journal of Visualized Experiments · doi:10.3791/57664 · Cited by 16 · see citing works

Modeling of osteosarcoma with induced pluripotent stem cells

Pang, L. K., Pena, M., Zhao, R., & Lee, D. (2020) · Stem Cell Research · doi:10.1016/j.scr.2020.102006 · Cited by 8 · see citing works

Abstract 5129: Model osteosarcoma by Li-Fraumeni syndrome patient-specific induced pluripotent stem cells

Lee, D., Su, J., Kim, H. S., Chang, B., Zhao, R., Papatsenko, D., Yuan, Y., Gingold, J. A., Xia, W., Darr, H., et al. (2015) · Cancer Research · doi:10.1158/1538-7445.am2015-5129

Abstract A18: Comprehensive identification of bone cancer driver genes by using Li-Fraumeni syndrome iPSCs

Zhou, R., Lin, Y.-H., Xu, A., Jewell, B. E., Liu, Y., Ruiying, Z., & Lee, D. (2018) · Clinical Cancer Research · doi:10.1158/1557-3265.sarcomas17-a18

Modeling Familial Cancer with Induced Pluripotent Stem Cells

Lee, D., Su, J., Kim, H. S., Chang, B., Papatsenko, D., Zhao, R., Yuan, Y., Gingold, J. A., Xia, W., Darr, H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.02.045 · Cited by 223 · see citing works