The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Antibiotic Resistance by Enzymatic Modification of Antibiotic Targets
Abstract
Antibiotic resistance remains a significant threat to modern medicine. Modification of the antibiotic target is a resistance strategy that is increasingly prevalent among pathogens. Examples include resistance to glycopeptide and polymyxin antibiotics that occurs via chemical modification of their molecular targets in the cell envelope. Similarly, many ribosome-targeting antibiotics are impaired by methylation of the rRNA. In these cases, the antibiotic target is subjected to enzymatic modification rather than genetic mutation, and in many instances the resistance enzymes are readily mobilized among pathogens. Understanding the enzymes responsible for these modifications is crucial to combat resistance. Here, we review our current understanding of enzymatic modification of antibiotic targets as well as discuss efforts to combat these resistance mechanisms.
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Cites
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316
Howden, B. P., Davies, J. K., Johnson, P. D. R., Stinear, T. P., & Grayson, M. L. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00042-09 · Cited by 962
Vancomycin-Resistant Staphylococcus aureus in the United States, 2002-2006
Sievert, D. M., Rudrik, J. T., Patel, J. B., McDonald, L. C., Wilkins, M. J., & Hageman, J. C. (2008) · Clinical Infectious Diseases · doi:10.1086/527392 · Cited by 483
Antibiotic resistance by enzyme inactivation: From mechanisms to solutions
De Pascale, G., & Wright, G. D. (2010) · ChemBioChem · doi:10.1002/cbic.201000067 · Cited by 94
Self-citation
Cited by
Molecular mechanisms of antibiotic resistance revisited
Darby, E. M., Trampari, E., Siasat, P., Gaya, M. S., Alav, I., Webber, M. A., & Blair, J. M. A. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00820-y · Cited by 1,398
Urinary Tract Infections: The Current Scenario and Future Prospects
Mancuso, G., Midiri, A., Gerace, E., Marra, M., Zummo, S., & Biondo, C. (2023) · Pathogens · doi:10.3390/pathogens12040623 · Cited by 396
Arsène, M. M. J., Davares, A. K. L., Viktorovna, P. I., Andreevna, S. L., Sarra, S., Khelifi, I., & Sergueïevna, D. M. (2022) · Veterinary World · doi:10.14202/vetworld.2022.662-671 · Cited by 274
Naik, G. A. R. R., Roy, A. A., Mutalik, S., & Dhas, N. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134977 · Cited by 47
Metadata
- Authors
- Schaenzer, A. J., & Wright, G. D.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 26
- Issue
- 8
- Pages
- 768-782
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W3030787643
- Cited by
- 192
- References
- 4
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
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