Antibiotic resistance by enzyme inactivation: From mechanisms to solutions
Abstract
Resistance is fertile: Bacteria evade antibiotics by using a number of methods, but the selection and optimization of enzymes that destroy or modify drugs is a particularly prominent mechanism. We review recent advances in our understanding of the molecular mechanisms of these enzymes as well as efforts to block their activities through small molecule inhibitors.
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- Authors
- De Pascale, G., & Wright, G. D.
- Affiliations
- Michael G. DeGroote Institute for Infectious Disease Research (CA)
- ORCID
- Wright, Gerard D.
- Venue
- ChemBioChem
- Publisher
- Wiley
- Published
- 2010-06-30
- Volume
- 11
- Issue
- 10
- Pages
- 1325-1334
- ISSN
- 1439-4227 (ISSN-L)
- 1439-7633
- OpenAlex
- W2116397655
- Cited by
- 94
- References
- 75
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 9 · 2023: 11 · 2022: 11 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ChemBioChem (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canada Research Chairs
- Javna Agencija za Raziskovalno Dejavnost RS
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- antibiotic resistance, enzyme inactivation, molecular mechanisms of resistance, small molecule inhibitors, enzyme inhibitors, drug resistance mechanisms
- MeSH terms
- Acetyltransferases, Anti-Bacterial Agents, beta-Lactamases, Enzyme Inhibitors, Models, Molecular, Drug Resistance, Bacterial, Small Molecule Libraries, beta-Lactamase Inhibitors
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