Cited by 94Antibiotic Resistance in BacteriaPharmaceutical and Antibiotic Environmental ImpactsDrug Transport and Resistance Mechanisms

Antibiotic resistance by enzyme inactivation: From mechanisms to solutions

De Pascale, Gianfranco, Wright, Gerard D.·2010·ChemBioChem

Abstract

Resistance is fertile: Bacteria evade antibiotics by using a number of methods, but the selection and optimization of enzymes that destroy or modify drugs is a particularly prominent mechanism. We review recent advances in our understanding of the molecular mechanisms of these enzymes as well as efforts to block their activities through small molecule inhibitors.

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Crossref · 10.1002/cbic.201000067

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75 of 75 references verified0 citation errors · 0 not checkable

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Authors
De Pascale, G., & Wright, G. D.
Affiliations
Michael G. DeGroote Institute for Infectious Disease Research (CA)
Venue
ChemBioChem
Publisher
Wiley
Published
2010-06-30
Volume
11
Issue
10
Pages
1325-1334
ISSN
  • 1439-4227 (ISSN-L)
  • 1439-7633
OpenAlex
W2116397655
Cited by
94
References
75
Citations by year
2026: 4 · 2025: 11 · 2024: 9 · 2023: 11 · 2022: 11 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 3
FWCI
0.25
Type
journal article
Language
en
Open access
closed
Locations
  • ChemBioChem (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Canada Research Chairs
  • Javna Agencija za Raziskovalno Dejavnost RS
  • Canadian Institutes of Health Research
  • Natural Sciences and Engineering Research Council of Canada
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
antibiotic resistance, enzyme inactivation, molecular mechanisms of resistance, small molecule inhibitors, enzyme inhibitors, drug resistance mechanisms
MeSH terms
Acetyltransferases, Anti-Bacterial Agents, beta-Lactamases, Enzyme Inhibitors, Models, Molecular, Drug Resistance, Bacterial, Small Molecule Libraries, beta-Lactamase Inhibitors

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