The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Liquid Biopsy of Methylation Biomarkers in Cell-Free DNA
Abstract
Liquid biopsies, in particular, analysis of cell-free DNA (cfDNA), have emerged as a promising noninvasive diagnostic approach in oncology. Abnormal distribution of DNA methylation is one of the hallmarks of many cancers and methylation changes occur early during carcinogenesis. Systemic analysis of cfDNA methylation profiles is being developed for cancer early detection, monitoring for minimal residual disease (MRD), predicting treatment response and prognosis, and tracing the tissue origin. This review highlights the advantages and disadvantages of ctDNA profiling for noninvasive diagnosis of early-stage cancers and explores recent advances in the clinical application of ctDNA methylation assays. We also summarize the technologies for ctDNA methylation analysis and provide a brief overview of the bioinformatic approaches for analyzing DNA methylation sequencing data.
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Cited by
Bridging biological cfDNA features and machine learning approaches
Moser, T., Kühberger, S., Lazzeri, I., Vlachos, G., & Heitzer, E. (2023) · Trends in Genetics · doi:10.1016/j.tig.2023.01.004 · Cited by 133
Richardson, S. A., Gulati, G., Harker, P. J. B., Redfern, A., Pearce, S. P., Karimpour, M., Hill, S. M., Makeev, V. J., Brennan, B., Lee, A. T., et al. (2025) · doi:10.1101/2025.04.25.25325254
Metadata
- Authors
- Luo, H., Wei, W., Ye, Z., Zheng, J., & Xu, R.-H.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 27
- Issue
- 5
- Pages
- 482-500
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W3123940477
- Cited by
- 319
- References
- 130
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Luo, H., Wei, W., Ye, Z., Zheng, J., & Xu, R.-H. (2021). Liquid Biopsy of Methylation Biomarkers in Cell-Free DNA. Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2020.12.011
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