The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity
Open accessAbstract
OBJECTIVE: Parental obesity can induce metabolic phenotypes in offspring independent of the inherited DNA sequence. Here we asked whether such non-genetic acquired metabolic traits can be passed on to a second generation that has never been exposed to obesity, even as germ cells. METHODS: We examined the F1, F2, and F3 a/a offspring derived from F0 matings of obese prediabetic A (vy) /a sires and lean a/a dams. After F0, only lean a/a mice were used for breeding. RESULTS: We found that F1 sons of obese founder males exhibited defects in glucose and lipid metabolism, but only upon a post-weaning dietary challenge. F1 males transmitted these defects to their own male progeny (F2) in the absence of the dietary challenge, but the phenotype was largely attenuated by F3. The sperm of F1 males exhibited changes in the abundance of several small RNA species, including the recently reported diet-responsive tRNA-derived fragments. CONCLUSIONS: These data indicate that induced metabolic phenotypes may be propagated for a generation beyond any direct exposure to an inducing factor. This non-genetic inheritance likely occurs via the actions of sperm noncoding RNA.
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“Both of the recent studies that identified diet-regulated sperm tRFs invoked a direct transcriptional interference mechanism for spermborne tRFs in the early embryo [11,25].”
Epigenetic inheritance at the agouti locus in the mouse
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Self-citationSperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder
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Parental olfactory experience influences behavior and neural structure in subsequent generations
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Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
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Fleming, T. P., Watkins, A. J., Velazquez, M. A., Mathers, J. C., Prentice, A. M., Stephenson, J., Barker, M., Saffery, R., Yajnik, C. S., Eckert, J. J., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30312-x · Cited by 1,147
Developmental origins of metabolic diseases
Hoffman, D. J., Powell, T. L., Barrett, E. S., & Hardy, D. B. (2021) · Physiological Reviews · doi:10.1152/physrev.00002.2020 · Cited by 466
Sperm epigenetics and influence of environmental factors
Donkin, I., & Barrès, R. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.02.006 · Cited by 331
Short, A. K., Yeshurun, S., Powell, R., Perreau, V. M., Fox, A., Kim, J. H., Pang, T. Y., & Hannan, A. J. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.82 · Cited by 166
Yeshurun, S., & Hannan, A. J. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0039-z · Cited by 121
Metadata
- Authors
- Cropley, J. E., Eaton, S. A., Aiken, A., Young, P. E., Giannoulatou, E., Ho, J. W. K., Buckland, M. E., Keam, S. P., Hutvagner, G., Humphreys, D. T., Langley, K. G., Henstridge, D. C., Martin, D. I. K., Febbraio, M. A., & Suter, C. M.
- Venue
- Molecular Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 5
- Issue
- 8
- Pages
- 699-708
- ISSN
- 2212-8778 (ISSN-L)
- OpenAlex
- W2474436782
- Cited by
- 167
- References
- 16
- FWCI
- 24.00
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cropley, J. E., Eaton, S. A., Aiken, A., Young, P. E., Giannoulatou, E., Ho, J. W. K., Buckland, M. E., Keam, S. P., Hutvagner, G., Humphreys, D. T., Langley, K. G., Henstridge, D. C., Martin, D. I. K., Febbraio, M. A., & Suter, C. M. (2016). Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity. Molecular Metabolism. https://doi.org/10.1016/j.molmet.2016.06.008
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