Transgenerational epigenetic influences of paternal environmental exposures on brain function and predisposition to psychiatric disorders
Abstract
In recent years, striking new evidence has demonstrated non-genetic inheritance of acquired traits associated with parental environmental exposures. In particular, this transgenerational modulation of phenotypic traits is of direct relevance to psychiatric disorders, including depression, post-traumatic stress disorder, and other anxiety disorders. Here we review the recent progress in this field, with an emphasis on acquired traits of psychiatric illnesses transmitted epigenetically via the male lineage. We discuss the transgenerational effects of paternal exposure to stress vs. positive stimuli, such as exercise, and discuss their impact on the behavioral, affective and cognitive characteristics of their progeny. Furthermore, we review the recent evidence suggesting that these transgenerational effects are mediated by epigenetic mechanisms, including changes in DNA methylation and small non-coding RNAs in the sperm. We discuss the urgent need for more research exploring transgenerational epigenetic effects in animal models and human populations. These future studies may identify epigenetic mechanisms as potential contributors to the 'missing heritability' observed in genome-wide association studies of psychiatric illnesses and other human disorders. This exciting new field of transgenerational epigenomics will facilitate the development of novel strategies to predict, prevent and treat negative epigenetic consequences on offspring health, and psychiatric disorders in particular.
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These epigenetic processes may have evolved in order to program the phenotype to effectively and rapidly adapt to new environmental demands.
“these epigenetic processes may have evolved in order to program the phenotype to effectively and rapidly adapt to new environmental demands (Fischer, 2014;Gapp et al., 2016;Yeshurun & Hannan, 2019).”
From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Yeshurun & Hannan, 2019
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Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms
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“A detailed review of this comprehensive body of work is provided elsewhere (see, for example, [71,72]).”
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Revisiting Epigenetics Fundamentals and Its Biomedical Implications
Meza-Menchaca, T., Albores-Medina, A., Heredia-Mendez, A. J., Ruíz-May, E., Ricaño-Rodríguez, J., Gallegos-García, V., Esquivel, A., Vettoretti-Maldonado, G., & Campos-Parra, A. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147927 · Cited by 15 · see citing works
- Authors
- Yeshurun, S., & Hannan, A. J.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Hannan, Anthony J.
- Venue
- Molecular Psychiatry
- Published
- 2018-03-08
- Volume
- 24
- Issue
- 4
- Pages
- 536-548
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2789306887
- Cited by
- 121
- References
- 125
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 6 · 2023: 12 · 2022: 14 · 2021: 21 · 2020: 21 · 2019: 15 · 2018: 16
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- transgenerational epigenetic inheritance, non-genetic inheritance, mental illness, depression, post-traumatic stress disorder, anxiety disorders, physical activity, sperm DNA methylation, missing heritability, epigenomics
- MeSH terms
- Mental Disorders, Brain, Disease Susceptibility, Environmental Exposure, Fathers, Genotype, Humans, Male, Phenotype, Spermatozoa, Paternal Exposure, DNA Methylation, Genetic Predisposition to Disease, Epigenesis, Genetic, Genome-Wide Association Study, Epigenomics
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