The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
Histological types of breast cancer: How special are they?
Open accessAbstract
Breast cancer is a heterogeneous disease, comprising multiple entities associated with distinctive histological and biological features, clinical presentations and behaviours and responses to therapy. Microarray‐based technologies have unravelled the molecular underpinning of several characteristics of breast cancer, including metastatic propensity and histological grade, and have led to the identification of prognostic and predictive gene expression signatures. Furthermore, a molecular taxonomy of breast cancer based on transcriptomic analysis has been proposed. However, microarray studies have primarily focused on invasive ductal carcinomas of no special type. Owing to the relative rarity of special types of breast cancer, information about the biology and clinical behaviour of breast cancers conveyed by histological type has not been taken into account. Histological special types of breast cancer account for up to 25% of all invasive breast cancers. Recent studies have provided direct evidence of the existence of genotypic–phenotypic correlations. For instance, secretory carcinomas of the breast consistently harbour the t(12;15) translocation that leads to the formation of the ETV6–NTRK3 fusion gene, adenoid cystic carcinomas consistently display the t(6;9) MYB–NFIB translocation and lobular carcinomas consistently show inactivation of the CDH1 gene through multiple molecular mechanisms. Furthermore, histopathological and molecular analysis of tumours from conditional mouse models has provided direct evidence for the causative role of specific genes in the genesis of specific histological special types of breast cancer. Here we review the associations between the molecular taxonomy of breast cancer and histological special types, discuss the possible origins of the heterogeneity of breast cancer and propose an approach for the identification of novel therapeutic targets based on the study of histological special types of breast cancer.
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1 retracted
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Tumor Heterogeneity in Breast Cancer
Turashvili, G., & Brogi, E. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00227 · Cited by 561
Genetic susceptibility to breast cancer
Mavaddat, N., Antoniou, A. C., Easton, D. F., & Garcia-Closas, M. (2010) · Molecular Oncology · doi:10.1016/j.molonc.2010.04.011 · Cited by 375
Breast Cancer Histopathology Image Classification Using an Ensemble of Deep Learning Models
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Optimization of liquid overlay technique to formulate heterogenic 3D co-cultures models
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Metadata
- Authors
- Weigelt, B., Geyer, F. C., & Reis-Filho, J. S.
- Venue
- Molecular Oncology
- Publisher
- Wiley
- Published
- 2010-04-18
- Volume
- 4
- Issue
- 3
- Pages
- 192-208
- ISSN
- 1574-7891 (ISSN-L)
- 1878-0261
- OpenAlex
- W2122197597
- Cited by
- 572
- References
- 131
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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