The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Reactive Oxygen Species (ROS)––Induced genetic and epigenetic alterations in human carcinogenesis
Abstract
Cancer is a multistage and complex process characterized by molecular alterations that underlie all three phases of its development: (i) initiation, (ii) promotion and (iii) progression. Some of these molecular events include alterations in gene expression that are regulated by both genetic and epigenetic mechanisms. On the other hand, "oxidative stress" implies a cellular state where ROS production exceeds the cell's ability to metabolize them resulting in excessive accumulation of ROS that overwhelms cellular defenses. Such state has been shown to regulate both genetic and epigenetic cascades underlying altered gene expression in human disease including cancer. Throughout this manuscript, we review the current state of knowledge on the role of ROS-induced oxidative stress in altering the genetic and epigenetic involvement during human carcinogenesis.
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Cites
Free radicals, metals and antioxidants in oxidative stress-induced cancer
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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
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Self-citationDetection and interpretation of altered methylation patterns in cancer cells
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Cited by
ROS and the DNA damage response in cancer
Srinivas, U. S., Tan, B. W. Q., Vellayappan, B. A., & Jeyasekharan, A. D. (2019) · Redox Biology · doi:10.1016/j.redox.2018.101084 · Cited by 2,144
“polyamine oxidase) [14], (iv) Endoplasmic reticulum (produce H2O2 as a byproduct during protein folding); or upon exposure to exogenous stress like ionizing radiation (IR), chemotherapeutic drugs and environmental insults, which affect the organelles and enzymes listed above [15].”
BackgroundROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases
Davalli, P., Mitic, T., Caporali, A., Lauriola, A., & D’Arca, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3565127 · Cited by 1,059
Valavanidis, A., Vlachogianni, T., Fiotakis, K., & Loridas, S. (2013) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph10093886 · Cited by 910
Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research
Ivashkevich, A., Redon, C. E., Nakamura, A. J., Martin, R. F., & Martin, O. A. (2012) · Cancer Letters · doi:10.1016/j.canlet.2011.12.025 · Cited by 462
The multifaceted role of reactive oxygen species in tumorigenesis
Kirtonia, A., Sethi, G., & Garg, M. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03536-5 · Cited by 452
Metadata
- Authors
- Ziech, D., Franco, R., Pappa, A., & Panayiotidis, M. I.
- Venue
- Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 711
- Issue
- 1-2
- Pages
- 167-173
- ISSN
- 0027-5107 (ISSN-L)
- 1386-1964
- OpenAlex
- W2093683863
- Cited by
- 568
- References
- 6
- FWCI
- 17.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ziech, D., Franco, R., Pappa, A., & Panayiotidis, M. I. (2011). Reactive Oxygen Species (ROS)––Induced genetic and epigenetic alterations in human carcinogenesis. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. https://doi.org/10.1016/j.mrfmmm.2011.02.015
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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