The multifaceted role of reactive oxygen species in tumorigenesis
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Redox homeostasis is an essential requirement of the biological systems for performing various normal cellular functions including cellular growth, differentiation, senescence, survival and aging in humans. The changes in the basal levels of reactive oxygen species (ROS) are detrimental to cells and often lead to several disease conditions including cardiovascular, neurological, diabetes and cancer. During the last two decades, substantial research has been done which clearly suggests that ROS are essential for the initiation, progression, angiogenesis as well as metastasis of cancer in several ways. During the last two decades, the potential of dysregulated ROS to enhance tumor formation through the activation of various oncogenic signaling pathways, DNA mutations, immune escape, tumor microenvironment, metastasis, angiogenesis and extension of telomere has been discovered. At present, surgery followed by chemotherapy and/or radiotherapy is the major therapeutic modality for treating patients with either early or advanced stages of cancer. However, the majority of patients relapse or did not respond to initial treatment. One of the reasons for recurrence/relapse is the altered levels of ROS in tumor cells as well as in cancer-initiating stem cells. One of the critical issues is targeting the intracellular/extracellular ROS for significant antitumor response and relapse-free survival. Indeed, a large number of FDA-approved anticancer drugs are efficient to eliminate cancer cells and drug resistance by increasing ROS production. Thus, the modulation of oxidative stress response might represent a potential approach to eradicate cancer in combination with FDA-approved chemotherapies, radiotherapies as well as immunotherapies.
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ROS play an essential role in carcinogenesis, affecting genomic instability, cell growth, angiogenesis, inflammation, metabolic reprogramming, metastatization, and resistance to apoptosis.
“ROS play an essential role in carcinogenesis, affecting multiple biological processes, including genomic instability, cell growth, angiogenesis, inflammation, metabolic reprogramming, metastatization, and resistance to apoptosis [77].”
From Chronic Inflammation, Oxidative Stress and Metabolic Plasticity: Three Players Driving the Pro-Tumorigenic Microenvironment in Malignant Mesothelioma (2023) · cites this paper as [77]
Elevated levels of intracellular ROS are known to be one of the reasons for genomic instability and carcinogenesis.
“Elevated levels of intracellular ROS are known to be one of the reasons for genomic instability and, hence, carcinogenesis [29].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [29]
ROS play a multifaceted, opposing role in cancer, favoring cancer onset at low doses and killing tumors at high doses.
“ROS are known to play a multifaced, opposing role in cancer, by favoring cancer onset at low doses on the one hand, and killing tumors at high doses on the other hand [29,55].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [29]
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Metabolic Regulation of Redox Balance in Cancer
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A role for GPx3 in activity of normal and leukemia stem cells
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Redox Regulation of MAP Kinase Phosphatase 3
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Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?
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Non-apoptotic cell death in malignant tumor cells and natural compounds
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Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
Gao, W., Wang, Y., Zhou, Y., Wang, X., & Yu, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01046-3 · Cited by 1,069 · see citing works
“It has been demonstrated by Lin X et al. that ROS may stimulate an invasive phenotype in TAMs derived from melanoma through the secretion of TNFα.343 Researchers have found several mitochondrial genes highly expressed in TAMs derived from melanomas, indicating ROS is the major cause of oxidative stress within TAMs.334…”
BackgroundInfluentialEmerging role of exosomes in cancer progression and tumor microenvironment remodeling
Paskeh, M. D. A., Entezari, M., Mirzaei, S., Zabolian, A., Saleki, H., Naghdi, M. J., Sabet, S., Khoshbakht, M. A., Hashemi, M., Hushmandi, K., et al. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01305-4 · Cited by 570 · see citing works
Self-citationAfzal, S., Manap, A. S. A., Attiq, A., Albokhadaim, I. F., Kandeel, M. K., & Alhojaily, S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1269581 · Cited by 423 · see citing works
Weaver, K., & Skouta, R. (2022) · Biomedicines · doi:10.3390/biomedicines10040891 · Cited by 273 · see citing works
“Recent studies showed that oxidative injuries were involved in neurodegeneration such as Alzheimer’s and Parkinson’s disease [53,54], cancer [55,56], diabetes [57], and cardiovascular diseases [58,59].”
BackgroundGuan, Z., Chen, J., Li, X., & Dong, N. (2020) · Bioscience Reports · doi:10.1042/bsr20201807 · Cited by 235 · see citing works
Ferroptosis as a potential target for cancer therapy
Chen, Z., Wang, W., Razak, S. R. A., Han, T., Ahmad, N. H., & Li, X. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05930-w · Cited by 208 · see citing works
Rauf, A., Khalil, A. A., Awadallah, S. M., Khan, S. A., Abu‐Izneid, T., Kamran, M., Hemeg, H. A., Mubarak, M. S., Khalid, A., & Wilairatana, P. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3784 · Cited by 201 · see citing works
“…instability, drug resistance, apoptotic resistance, and alterations in cellular metabolism in various cancer cells (de la Vega Rojo et al., 2018; Kerins & Ooi, 2018) Depleted NRF2 showed reduced tumor growth through enhancement of oxidative stress-dependent cellular death (Kirtonia et al., 2020 ).”
BackgroundInfluentialDiosgenin: An Updated Pharmacological Review and Therapeutic Perspectives
Semwal, P., Painuli, S., Abu-Izneid, T., Rauf, A., Sharma, A., Daştan, S. D., Kumar, M., Alshehri, M. M., Taheri, Y., Das, R., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1035441 · Cited by 195 · see citing works
“The oxidative stress caused by the reactive oxygen stress leads to various ailments such as neurological disorders, cardiovascular diseases, and cancer [58 – 60].”
Long non-coding RNAs in the doxorubicin resistance of cancer cells
Ashrafizaveh, S., Ashrafizadeh, M., Zarrabi, A., Husmandi, K., Zabolian, A., Shahinozzaman, M., Aref, A. R., Hamblin, M. R., Nabavi, N., Crea, F., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.03.018 · Cited by 192 · see citing works
CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3p
Xi, Y., Shen, Y., Wu, D., Zhang, J., Lin, C., Wang, L., Yu, C., Yu, B., & Shen, W. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01615-8 · Cited by 165 · see citing works
“Since cancer and normal cells show physiological differences in iron and lipid metabolism along with aberrant ROS production [22, 23], cancer cells may be more susceptible to modulation in ferroptosis than normal cells.”
BackgroundReactive Oxygen Species Bridge the Gap between Chronic Inflammation and Tumor Development
Yu, W., Tu, Y., Long, Z., Liu, J., Kong, D., Peng, J., Wu, H., Zheng, G., Zhao, J., Chen, Y., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2606928 · Cited by 161 · see citing works
“ROS reportedly trigger EMT by activating various pathways, including E-cadherin, N-cadherin, vimentin, and Snail [209].”
Reactive Oxygen Species and Antitumor Immunity—From Surveillance to Evasion
Kotsafti, A., Scarpa, M., Castagliuolo, I., & Scarpa, M. (2020) · Cancers · doi:10.3390/cancers12071748 · Cited by 157 · see citing works
“As previously described, low levels of ROS are necessary for proper T cell activation, proliferation and differentiation, while high ROS have been noticed as one of the major factors for immunosuppression and inhibition for T cell activation and proliferation inside the TME [53,104].”
BackgroundAshrafizadeh, M., Zarrabi, A., Hashemi, F., Moghadam, E. R., Hashemi, F., Entezari, M., Hushmandi, K., Mohammadinejad, R., & Najafi, M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117984 · Cited by 151 · see citing works
Zhao, Z., Dong, S., Liu, Y., Wang, J., Ba, L., Zhang, C., Cao, X., Wu, C., & Yang, P. (2022) · ACS Nano · doi:10.1021/acsnano.2c06646 · Cited by 152 · see citing works
Mirzaei, S., Hushmandi, K., Zabolian, A., Saleki, H., Torabi, S. M., Ranjbar, A., SeyedSaleh, S., Sharifzadeh, S. O., Khan, H. Z., Ashrafizadeh, M., et al. (2021) · Molecules · doi:10.3390/molecules26082382 · Cited by 150 · see citing works
Lu, Y., Pan, Q., Gao, W., Pu, Y., Luo, K., He, B., & Gu, Z. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2021.121335 · Cited by 149 · see citing works
Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response
Ashrafizadeh, M., Paskeh, M. D. A., Mirzaei, S., Gholami, M. H., Zarrabi, A., Hashemi, F., Hushmandi, K., Hashemi, M., Nabavi, N., Crea, F., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02293-6 · Cited by 147 · see citing works
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“prostrate carcinoma.(203,204) Robust activation of STAT3 has been associated with radio and chemoresistance because of an increase in CD133 CSCs in thyroid cancer.”
BackgroundSelf-citationPaskeh, M. D. A., Mirzaei, S., Ashrafizadeh, M., Zarrabi, A., & Sethi, G. (2021) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s336858 · Cited by 135 · see citing works
“It is obvious that enhanced ROS generation can reduce viability of HCC cells via mediating apoptosis.(99,100) A recent experiment has shed more light on the role of ROS in HCC.”
BackgroundSelf-citationFerroptosis: An emerging approach for targeting cancer stem cells and drug resistance
Elgendy, S. M., Alyammahi, S. K., Alhamad, D. W., Abdin, S. M., & Omar, H. A. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.103095 · Cited by 134 · see citing works
Zhang, J., Yao, M., Xia, S., Zeng, F., & Liu, Q. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00682-7 · Cited by 139 · see citing works
Celastrol in cancer therapy: Recent developments, challenges and prospects
Lim, H. Y., Ong, P. S., Wang, L., Goel, A., Ding, L., Li-Ann Wong, A., Ho, P. C.-L., Sethi, G., Xiang, X., & Goh, B. C. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.08.030 · Cited by 118 · see citing works
Self-citationMirzaei, S., Zarrabi, A., Hashemi, F., Zabolian, A., Saleki, H., Azami, N., Hamzehlou, S., Farahani, M. V., Hushmandi, K., Ashrafizadeh, M., et al. (2021) · Antioxidants · doi:10.3390/antiox10030349 · Cited by 118 · see citing works
Rationalizing the therapeutic potential of apigenin against cancer
Ahmed, S. A., Parama, D., Daimari, E., Girisa, S., Banik, K., Harsha, C., Dutta, U., & Kunnumakkara, A. B. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118814 · Cited by 113 · see citing works
Yang, Y., Liu, L., Tian, Y., Gu, M., Wang, Y., Ashrafizadeh, M., Aref, A. R., Cañadas, I., Klionsky, D. J., Goel, A., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216659 · Cited by 109 · see citing works
Cao, Y., Wang, J., Tian, H., & Fu, G. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01621-y · Cited by 108 · see citing works
“Antitumor drugs anthracyclines and topoisomerase inhibitors such as doxorubicin, adriamycin, daunorubicin, and epirubicin can block DNA synthesis, topoisomerase II activity and complex I/II and increase mitochondrial ROS production to kill tumor cells [14, 15].”
In Vitro Cytotoxic Activity of African Plants: A Review
Canga, I. L. V., Vita, P., Oliveira, A. I., Castro, M. A., & Pinho, C. (2022) · Molecules · doi:10.3390/molecules27154989 · Cited by 108 · see citing works
“It is also known that reactive oxygen species (ROS) are involved in tumor formation through the activation of various oncogenic signaling pathways, DNA mutations, immune escape, the tumor microenvironment, metastasis, and angiogenesis [1].”
BackgroundRegulation of CD8+ T cells by lipid metabolism in cancer progression
Tang, Y., Chen, Z., Zuo, Q., & Kang, Y. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01224-z · Cited by 114 · see citing works
“High ROS levels are major factors that inhibit T-cell activation and proliferation in the tumor microenvironment [114].”
BackgroundНеганова, М. Е., Liu, J., Aleksandrova, Y. R., Klochkov, S. G., & Fan, R. (2021) · Cancers · doi:10.3390/cancers13236062 · Cited by 110 · see citing works
“Free radicals that cause genetic mutations can contribute to the initiation of the processes of normal cell transformation into a tumor cell, while simultaneously playing an essential role in all carcinogenesis stages [23,24].”
BackgroundRecent advances in waste-recycled nanomaterials for biomedical applications: Waste-to-wealth
Elkodous, M. A., El‐Husseiny, H. M., El-Sayyad, G. S., Hashem, A. H., Doghish, A. S., Elfadil, D., Radwan, Y., El-Zeiny, H. M., Bedair, H., Ikhdair, O. A., et al. (2021) · Nanotechnology Reviews · doi:10.1515/ntrev-2021-0099 · Cited by 102 · see citing works
Zhang, H., Wang, M., He, Y., Deng, T., Liu, R., Wang, W., Zhu, K., Bai, M., Ning, T., Yang, H., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04406-z · Cited by 102 · see citing works
“Since aberrant lipid and iron metabolism, along with ROS production, are some of the physiological differences between cancer and normal cells [13, 14], and play essential roles in regulating ferroptosis, cancer cells could be more susceptible to modulation in this death pathway compared to normal cells [15].”
BackgroundReactive Oxygen Species: A Crosslink between Plant and Human Eukaryotic Cell Systems
Guo, W., Xing, Y., Luo, X., Li, F., Ren, M., & Liang, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713052 · Cited by 107 · see citing works
How to improve photodynamic therapy-induced antitumor immunity for cancer treatment?
Zhang, M., Zhao, Y., Ma, H., Sun, Y., & Cao, J. (2022) · Theranostics · doi:10.7150/thno.72465 · Cited by 97 · see citing works
“Flow cytometry detection of CD40 and CD86 on CD11c+ DCs showed that after FS@PMPt treatment, CD8+ T cell infiltration was increased, while the proportion of Tregs was decreased.”
BackgroundInfluentialNanomedicine Strategies in Conquering and Utilizing the Cancer Hypoxia Environment
Pan, Y., Liu, L., Mou, X., & Cai, Y. (2023) · ACS Nano · doi:10.1021/acsnano.3c07763 · Cited by 98 · see citing works
Trombetti, S., Cesaro, E., Catapano, R., Sessa, R., Bianco, A. L., Izzo, P., & Grosso, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052470 · Cited by 91 · see citing works
“The most abundant non-enzymatic ROS scavenger, glutathione (GSH) and its related enzymatic activities including glutathione reductase (GR), glutathione peroxidase (GPx) and glutathione S-transferase (GST) participate in H2O2 detoxification (Figure 2) and play a critical role in different cellular processes such as pro…”
BackgroundGraphene oxide nanoarchitectures in cancer biology: Nano-modulators of autophagy and apoptosis
Taheriazam, A., Abad, G. G. Y., Hajimazdarany, S., Imani, M. H., Ziaolhagh, S., Zandieh, M. A., Bayanzadeh, S. D., Mirzaei, S., Hamblin, M. R., Entezari, M., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.028 · Cited by 93 · see citing works
Tuli, H. S., Kaur, J., Vashishth, K., Sak, K., Sharma, U., Choudhary, R., Behl, T., Singh, T., Sharma, S., Saini, A. K., et al. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03421-z · Cited by 88 · see citing works
“On the other hand, it is well known that excessive production of ROS and ROS-induced oxidative stress can play a substantial role in tumorigenesis, causing damages to vital biomolecules, such as DNA, proteins and lipids (Srinivas et al. 2019; Kirtonia et al. 2020; Wang et al. 2020; Ulker et al. 2022).”
BackgroundSelf-citationThe interplay between autophagy and apoptosis: its implication in lung cancer and therapeutics
Biswas, U., Roy, R., Ghosh, S., & Chakrabarti, G. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216662 · Cited by 89 · see citing works
Ashrafizadeh, M., Ang, H. L., Moghadam, E. R., Mohammadi, S., Zarrin, V., Hushmandi, K., Samarghandian, S., Zarrabi, A., Najafi, M., Mohammadinejad, R., et al. (2020) · Biomolecules · doi:10.3390/biom10071040 · Cited by 87 · see citing works
“Generally, it is believed that enhancing level of oxidative stress can lead to a reduction in the viability of cancer cells by predisposing them into apoptosis [135,136].”
BackgroundRole of the Synergistic Interactions of Environmental Pollutants in the Development of Cancer
Lagunas‐Rangel, F. A., Linnea‐Niemi, J. V., Kudłak, B., Williams, M. J., Jönsson, J., & Schiöth, H. B. (2022) · GeoHealth · doi:10.1029/2021gh000552 · Cited by 94 · see citing works
“During various pathological processes, including cardiovascular, neurological, diabetes, and cancer, ROS levels increase (Kirtonia et al., 2020; Lagunas-Rangel, 2020).”
BackgroundOxidative Stress and Age-Related Tumors
Carlo, E. D., & Sorrentino, C. (2024) · Antioxidants · doi:10.3390/antiox13091109 · Cited by 96 · see citing works
“76].”
BackgroundInfluentialNanomaterial-based regulation of redox metabolism for enhancing cancer therapy
Jia, X., Wang, Y., Qiao, Y., Jiang, X., & Li, J. (2024) · Chemical Society Reviews · doi:10.1039/d4cs00404c · Cited by 87 · see citing works
Ashrafizadeh, M., Saebfar, H., Gholami, M. H., Hushmandi, K., Zabolian, A., Bikarannejad, P., Hashemi, M., Daneshi, S., Mirzaei, S., Sharifi, E., et al. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2041598 · Cited by 86 · see citing works
Targeting oxidative stress-mediated regulated cell death as a vulnerability in cancer
Chen, D., Guo, Z., Yao, L., Sun, Y., Dian, Y., Zhao, D., Ke, Y., Zeng, F., Zhang, C., Deng, G., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103686 · Cited by 88 · see citing works
“…myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs), and tumor-associated macrophages (TAMs), and collectively leading to the suppression of NK cells and CTLs through direct ROS-induced damage and the release of immunosuppressive cytokines such as IL-10 and TGF-β [116,117].”
Oshi, M., Gandhi, S., Yan, L., Tokumaru, Y., Wu, R., Yamada, A., Matsuyama, R., Endo, I., & Takabe, K. (2022) · Breast Cancer Research and Treatment · doi:10.1007/s10549-022-06633-0 · Cited by 88 · see citing works
“Proper T cell activation, proliferation, and differentiation depend on low levels of ROS [59, 60].”
BackgroundAshrafizadeh, M., Mirzaei, S., Hushmandi, K., Rahmanian, V., Zabolian, A., Raei, M., Farahani, M. V., Goharrizi, M. A. S. B., Khan, H. Z., Zarrabi, A., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119649 · Cited by 80 · see citing works
Role of Telomeres and Telomeric Proteins in Human Malignancies and Their Therapeutic Potential
Fernandes, S. G., Dsouza, R., Pandya, G., Kirtonia, A., Tergaonkar, V., Lee, S. Y., Garg, M., & Khattar, E. (2020) · Cancers · doi:10.3390/cancers12071901 · Cited by 79 · see citing works
Self-citationThe gut microbiota metabolite urolithin A inhibits NF-κB activation in LPS stimulated BMDMs
Abdelazeem, K. N. M., Kalo, M. Z., Beer‐Hammer, S., & Lang, F. J. W. (2021) · Scientific Reports · doi:10.1038/s41598-021-86514-6 · Cited by 79 · see citing works
FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion
Li, S., Han, S., Zhang, Q., Zhu, Y., Zhang, H., Wang, J., Zhao, Y., Zhao, J., Su, L., Li, L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31187-6 · Cited by 77 · see citing works
Anti-Inflammatory and Anticancer Properties of Birch Bark-Derived Betulin: Recent Developments
Tuli, H. S., Sak, K., Gupta, D., Kaur, G., Aggarwal, D., Parashar, N. C., Choudhary, R., Yerer, M. B., Kaur, J., Kumar, M., et al. (2021) · Plants · doi:10.3390/plants10122663 · Cited by 76 · see citing works
Self-citationMitochondria: The metabolic switch of cellular oncogenic transformation
Tan, Y. Q., Zhang, X., Zhang, S., Zhu, T., Garg, M., Lobie, P. E., & Pandey, V. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188534 · Cited by 75 · see citing works
Self-citationThe evolutionary legacy of immune checkpoint inhibitors
Kaushik, I., Ramachandran, S., Zabel, C., Gaikwad, S., & Srivastava, S. K. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.03.020 · Cited by 79 · see citing works
Makvandi, P., Ghomi, M., Ashrafizadeh, M., Tafazoli, A., Agarwal, T., Delfi, M., Akhtari, J., Zare, E. N., Padil, V. V. T., Zarrabi, A., et al. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116952 · Cited by 75 · see citing works
Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
Behroozaghdam, M., Dehghani, M., Zabolian, A., Kamali, D., Javanshir, S., Sadi, F. H., Hashemi, M., Tabari, T., Rashidi, M., Mirzaei, S., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04551-4 · Cited by 74 · see citing works
The application of nanoparticles-based ferroptosis, pyroptosis and autophagy in cancer immunotherapy
Deng, W., Shang, H., Tong, Y., Liu, X., Huang, Q., He, Y. T., Wu, J., Ba, X., Chen, Z., Chen, Y., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02297-8 · Cited by 74 · see citing works
“As a key component of ferroptosis, Reactive oxygen species could induce lipid peroxidation that can have significant implications for the modulation of immunity in human malignancies, in addition to its role in oxidative stress [59].”
BackgroundInsights into the Role of Oxidative Stress in Ovarian Cancer
Ding, D., Xie, L., Shen, Y., Li, J., Guo, Y., Fu, Y., Liu, F.-Y., & Han, F. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8388258 · Cited by 72 · see citing works
Yu, L., Huang, K., Liao, Y., Wang, L., Sethi, G., & Ma, Z. (2024) · Cell Proliferation · doi:10.1111/cpr.13644 · Cited by 71 · see citing works
“55,56 Emerging evidence has revealed that ferroptosis exerts a critical role in regulating tumour immunity, particularly in PD1 checkpoint blockade therapies.”
BackgroundSelf-citationMicroRNAs as Modulators of Oral Tumorigenesis—A Focused Review
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- Authors
- Kirtonia, A., Sethi, G., & Garg, M.
- Affiliations
- Amity University (IN)
- National University of Singapore (SG)
- Corresponding author
- Sethi, Gautam
- Garg, Manoj
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2020-05-01
- Volume
- 77
- Issue
- 22
- Pages
- 4459-4483
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11105050
- OpenAlex
- W3022746266
- Cited by
- 452
- References
- 257
- Citations by year
- 2026: 33 · 2025: 45 · 2024: 90 · 2023: 72 · 2022: 106 · 2021: 80 · 2020: 26
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Department of Biotechnology , Ministry of Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- reactive oxygen species, carcinogenesis, redox homeostasis, oxidative stress, metastasis, angiogenesis, oncogenic signaling, DNA mutations, tumor microenvironment, cancer stem cells, drug resistance, anticancer agents, immunotherapy, radiotherapy, chemotherapy
- MeSH terms
- Animals, Humans, Neoplasm Recurrence, Local, Neoplasms, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Carcinogenesis
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