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Cited by 227Advanced Neuroimaging Techniques and ApplicationsAdvanced MRI Techniques and ApplicationsFunctional Brain Connectivity Studies

The DOI matches its Crossref record, with a small difference in title or year; 74 of the 77 references it cites were found in a registry or an index.

Is diffusion anisotropy an accurate monitor of myelination?

Mädler, Burkhard, Drabycz, Sylvia A., Kolind, Shannon H., Whittall, Kenneth P., MacKay, Alexander L.·2008·Magnetic Resonance Imaging
DOI 10.1016/j.mri.2008.01.047
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Abstract

We compare T2-relaxation and diffusion tensor data from normal human brain. The relationships between myelin-water fraction (MWF) and various diffusion tensor measures [e.g., fractional anisotropy (FA), perpendicular diffusivity (ADC perpendicular) and mean diffusivity ] in white matter (WM) and gray matter (GM) structures in the brain were examined in 16 normal volunteers at 1.5 T and 6 normal subjects at 3.0 T and mean diffusivity. We found some degree of linear correlation between these measurements, but by using region of interest (ROI)-based analysis, we also observed several structures which seemed to deviate significantly from a linear relationship. From all investigated relationships between various diffusion tensor measures and myelin-water content, FA and ADC perpendicular yielded the highest correlation coefficients with MWF. However, diffusion anisotropy was also significantly influenced by factors other than myelin-water content. The less operator-dependent voxel-based analysis (VBA) between myelin-water and diffusional anisotropy measures is proposed as an innovative alternative to ROI-based analysis. We confirmed that WM structures, in general, have higher diffusional anisotropy than GM structures and also have higher myelin-water content. However, our findings suggest that in the highly organized fibre arrangement of compact WM structures such as the genu of the corpus callosum, elevated degrees of diffusional anisotropies are measured, which do not necessaril…

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Research works printed but not linked: 5

  1. Mädler, 2002, Correlation of multicomponent T2-relaxation data with diffusion tensor anisotropy measures in human brain, Proc ISMRM, 9
  2. Bells, 2007, Comparison of linear combination filtering to DTI and MTR in whole brain myelin-water imaging, Proc ISMRM, 15, 1606
  3. Mädler, 2006, In-vivo 3D multi-component T2-relaxation measurements for quantitative myelin imaging at 3T, Proc ISMRM, 13, 2112
  4. Laidlaw, 1999, Evaluating effects of diffusion weighting choice on accuracy of diffusion tensor MRI of fixed mouse spinal cord, Proc ISMRM, 1786
  5. Pajevic, 1999, Color schemes to represent the orientation of anisotropic tissues from diffusion tensor data: application to white matter fiber tract mapping in the human brain, Magn Reson Med, 42, 526, 10.1002/(SICI)1522-2594(199909)42:3<526::AID-MRM15>3.0.CO;2-J · DOI

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Metadata

Authors
Mädler, B., Drabycz, S. A., Kolind, S. H., Whittall, K. P., & MacKay, A. L.
Affiliations
  • University of British Columbia Hospital (CA)
  • University of Calgary (CA)
Corresponding author
Mädler, Burkhard
ORCID
Venue
Magnetic Resonance Imaging
Publisher
Elsevier BV
Published
2008-09
Volume
26
Issue
7
Pages
874-888
ISSN
0730-725X (ISSN-L)
DOI
10.1016/j.mri.2008.01.047
OpenAlex
W2008655880
Cited by
227
References
77
Citations by year
2026: 5 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 18 · 2020: 11 · 2019: 14 · 2018: 18 · 2017: 14 · 2016: 12 · 2015: 22 · 2014: 13 · 2013: 22 · 2012: 10
FWCI
11.04
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Magnetic Resonance Imaging (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Bundesministerium für Bildung und Forschung
  • Killam Trusts
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
diffusion anisotropy, myelination, myelin water fraction, fractional anisotropy, white matter, gray matter, T2 relaxation, mean diffusivity, corpus callosum, forceps minor, forceps major, voxel-based analysis, restricted diffusion
MeSH terms
Adolescent, Adult, Brain, Brain Mapping, Female, Humans, Male, Middle Aged, Nerve Fibers, Myelinated, Water, Linear Models, Anisotropy, Diffusion Magnetic Resonance Imaging

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