Cited by 227Advanced Neuroimaging Techniques and ApplicationsAdvanced MRI Techniques and ApplicationsFunctional Brain Connectivity Studies

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Is diffusion anisotropy an accurate monitor of myelination?

Mädler, Burkhard, Drabycz, Sylvia A., Kolind, Shannon H., Whittall, Kenneth P., MacKay, Alexander L.·2008·Magnetic Resonance Imaging

DOI 10.1016/j.mri.2008.01.047

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Abstract

We compare T2-relaxation and diffusion tensor data from normal human brain. The relationships between myelin-water fraction (MWF) and various diffusion tensor measures [e.g., fractional anisotropy (FA), perpendicular diffusivity (ADC perpendicular) and mean diffusivity ] in white matter (WM) and gray matter (GM) structures in the brain were examined in 16 normal volunteers at 1.5 T and 6 normal subjects at 3.0 T and mean diffusivity. We found some degree of linear correlation between these measurements, but by using region of interest (ROI)-based analysis, we also observed several structures which seemed to deviate significantly from a linear relationship. From all investigated relationships between various diffusion tensor measures and myelin-water content, FA and ADC perpendicular yielded the highest correlation coefficients with MWF. However, diffusion anisotropy was also significantly influenced by factors other than myelin-water content. The less operator-dependent voxel-based analysis (VBA) between myelin-water and diffusional anisotropy measures is proposed as an innovative alternative to ROI-based analysis. We confirmed that WM structures, in general, have higher diffusional anisotropy than GM structures and also have higher myelin-water content. However, our findings suggest that in the highly organized fibre arrangement of compact WM structures such as the genu of the corpus callosum, elevated degrees of diffusional anisotropies are measured, which do not necessaril…

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Authors: Mädler, B., Drabycz, S. A., Kolind, S. H., Whittall, K. P., & MacKay, A. L.
Affiliations: University of British Columbia Hospital (CA)
University of Calgary (CA)
Corresponding author: Mädler, Burkhard
ORCID: Mädler, Burkhard
Kolind, Shannon H.
Venue: Magnetic Resonance Imaging
Publisher: Elsevier BV
Published: 2008-09
Volume: 26
Issue: 7
Pages: 874-888
ISSN: 0730-725X (ISSN-L)
DOI: 10.1016/j.mri.2008.01.047
OpenAlex: W2008655880
Cited by: 227
References: 77
Citations by year: 2026: 5 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 18 · 2020: 11 · 2019: 14 · 2018: 18 · 2017: 14 · 2016: 12 · 2015: 22 · 2014: 13 · 2013: 22 · 2012: 10
FWCI: 11.04
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Magnetic Resonance Imaging (publishedVersion)
PubMed (publishedVersion)
Funders: Bundesministerium für Bildung und Forschung
Killam Trusts
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: diffusion anisotropy, myelination, myelin water fraction, fractional anisotropy, white matter, gray matter, T2 relaxation, mean diffusivity, corpus callosum, forceps minor, forceps major, voxel-based analysis, restricted diffusion
MeSH terms: Adolescent, Adult, Brain, Brain Mapping, Female, Humans, Male, Middle Aged, Nerve Fibers, Myelinated, Water, Linear Models, Anisotropy, Diffusion Magnetic Resonance Imaging

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Is diffusion anisotropy an accurate monitor of myelination?

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