Cited by 240Fungal Biology and ApplicationsPolysaccharides Composition and ApplicationsPolysaccharides and Plant Cell Walls

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β-Glucans in promoting health: Prevention against mutation and cancer

Mantovani, Mário S., Bellini, Marilanda F., Angeli, José Pedro F., Oliveira, Rodrigo J., Silva, Ariane F., Ribeiro, Lúcia R.·2008·Mutation Research/Reviews in Mutation Research

DOI 10.1016/j.mrrev.2007.07.002

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Abstract

The polysaccharides beta-glucans occur as a principal component of the cellular walls. Some microorganisms, such as yeast and mushrooms, and also cereals such as oats and barley, are of economic interest because they contain large amounts of beta-glucans. These substances stimulate the immune system, modulating humoral and cellular immunity, and thereby have beneficial effect in fighting infections (bacterial, viral, fungal and parasitic). beta-Glucans also exhibit hypocholesterolemic and anticoagulant properties. Recently, they have been demonstrated to be anti-cytotoxic, antimutagenic and anti-tumorogenic, making them promising candidate as pharmacological promoters of health.

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Authors: Mantovani, M. S., Bellini, M. F., Angeli, J. P. F., Oliveira, R. J., Silva, A. F., & Ribeiro, L. R.
Affiliations: Universidade Estadual de Londrina (BR)
Instituto de Biociências, Letras e Ciências Exatas, câmpus de São José do Rio Preto (BR)
Universidade Estadual Paulista (Unesp) (BR)
Corresponding author: Mantovani, Mário S.
ORCID: Mantovani, Mário S.
Bellini, Marilanda F.
Angeli, José Pedro F.
Oliveira, Rodrigo J.
Ribeiro, Lúcia R.
Venue: Mutation Research/Reviews in Mutation Research
Publisher: Elsevier BV
Published: 2008-03
Volume: 658
Issue: 3
Pages: 154-161
ISSN: 1383-5742 (ISSN-L)
DOI: 10.1016/j.mrrev.2007.07.002
OpenAlex: W2080014425
Cited by: 240
References: 59
Citations by year: 2026: 1 · 2025: 7 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 14 · 2019: 16 · 2018: 9 · 2017: 18 · 2016: 18 · 2015: 26 · 2014: 25 · 2013: 20 · 2012: 12
FWCI: 0.94
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Mutation Research/Reviews in Mutation Research (publishedVersion)
PubMed (publishedVersion)
Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
UNESP Institutional Repository (São Paulo State University) (submittedVersion)
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics: Health Sciences › Medicine › Pharmacology (medical) › Fungal Biology and Applications
Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
Keywords: β-glucan, polysaccharides, immunomodulation, antimutagenic activity, anticancer activity, cholesterol-lowering effect, anticoagulant activity, health promotion, yeast, mushrooms, oat, barley, infection resistance
MeSH terms: Animals, Anti-Infective Agents, Antineoplastic Agents, Health Promotion, Humans, Models, Biological, Mutation, Neoplasms, Antimutagenic Agents, Cytoprotection, beta-Glucans

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β-Glucans in promoting health: Prevention against mutation and cancer

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