The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
β-Glucans in promoting health: Prevention against mutation and cancer
Abstract
The polysaccharides beta-glucans occur as a principal component of the cellular walls. Some microorganisms, such as yeast and mushrooms, and also cereals such as oats and barley, are of economic interest because they contain large amounts of beta-glucans. These substances stimulate the immune system, modulating humoral and cellular immunity, and thereby have beneficial effect in fighting infections (bacterial, viral, fungal and parasitic). beta-Glucans also exhibit hypocholesterolemic and anticoagulant properties. Recently, they have been demonstrated to be anti-cytotoxic, antimutagenic and anti-tumorogenic, making them promising candidate as pharmacological promoters of health.
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“It is of special interest that not only laminarans, but also other β-d-glucans, isolated from yeast, fungi and cereals demonstrated anti-cytotoxic, anti-mutagenic, and anti-tumorigenic properties, making this class of polysaccharides a promising promoter of health [89].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [89]
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Cites
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Immunomodulation and Anti-Cancer Activity of Polysaccharide-Protein Complexes
Ooi, V. E. C., & Liu, F. (2000) · Current Medicinal Chemistry · doi:10.2174/0929867003374705 · Cited by 871
Fungal β-Glucans and Mammalian Immunity
Brown, G. D., & Gordon, S. (2003) · Immunity · doi:10.1016/s1074-7613(03)00233-4 · Cited by 668
Correlation between antitumor activity, molecular weight, and conformation of lentinan
Zhang, L., Li, X., Xu, X., & Zeng, F. (2005) · Carbohydrate Research · doi:10.1016/j.carres.2005.02.032 · Cited by 323
Natural and Modified (1→3)-β-D-Glucans in Health Promotion and Disease Alleviation
Zeković, D. B., Kwiatkowski, S., Vrvić, M. M., Jakovljević, D. M., & Moran, C. A. (2005) · Critical Reviews in Biotechnology · doi:10.1080/07388550500376166 · Cited by 310
The Hypocholesterolemic Effects of β-Glucan in Oatmeal and Oat Bran
Davidson, M. (1991) · JAMA · doi:10.1001/jama.1991.03460140061027 · Cited by 272
The cytokine stimulating activity of (1→3)-β-d-glucans is dependent on the triple helix conformation
Falch, B. M. H., Espevik, T., Ryan, L., & Stokke, B. T. (2000) · Carbohydrate Research · doi:10.1016/s0008-6215(00)00222-6 · Cited by 241
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Antitumor .BETA.-Glucan from the Cultured Fruit Body of Agaricus blazei.
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Comparative tumor‐inhibitory and anti‐bacterial activity of soluble and particulate glucan
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Anticancer polysaccharides from natural resources: A review of recent research
Zong, A., Cao, H., & Wang, F. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.07.026 · Cited by 667
Edible mushrooms: Role in the prevention of cardiovascular diseases
Guillamón, E., Garcia-Lafuente, A. M., Lozano, M., D’Arrigo, M., Rostagno, M. A., Villares, A., & Martínez, J. A. (2010) · Fitoterapia · doi:10.1016/j.fitote.2010.06.005 · Cited by 435
Review of natural products with hepatoprotective effects
Madrigal‐Santillán, E. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i40.14787 · Cited by 394
Jönsson, M., Allahgholi, L., Sardari, R. R. R., Hreggviðsson, G. Ó., & Karlsson, E. N. (2020) · Molecules · doi:10.3390/molecules25040930 · Cited by 297
Metadata
- Authors
- Mantovani, M. S., Bellini, M. F., Angeli, J. P. F., Oliveira, R. J., Silva, A. F., & Ribeiro, L. R.
- Affiliations
- Universidade Estadual de Londrina (BR)
- Instituto de Biociências, Letras e Ciências Exatas, câmpus de São José do Rio Preto (BR)
- Universidade Estadual Paulista (Unesp) (BR)
- Corresponding author
- Mantovani, Mário S.
- ORCID
- Venue
- Mutation Research/Reviews in Mutation Research
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 658
- Issue
- 3
- Pages
- 154-161
- ISSN
- 1383-5742 (ISSN-L)
- OpenAlex
- W2080014425
- Cited by
- 240
- References
- 59
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 14 · 2019: 16 · 2018: 9 · 2017: 18 · 2016: 18 · 2015: 26 · 2014: 25 · 2013: 20 · 2012: 12
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mutation Research/Reviews in Mutation Research (publishedVersion)
- PubMed (publishedVersion)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
- UNESP Institutional Repository (São Paulo State University) (submittedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Fungal Biology and Applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Keywords
- β-glucan, polysaccharides, immunomodulation, antimutagenic activity, anticancer activity, cholesterol-lowering effect, anticoagulant activity, health promotion, yeast, mushrooms, oat, barley, infection resistance
- MeSH terms
- Animals, Anti-Infective Agents, Antineoplastic Agents, Health Promotion, Humans, Models, Biological, Mutation, Neoplasms, Antimutagenic Agents, Cytoprotection, beta-Glucans
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