The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Inducing chimeric antigen receptor (CAR) regulatory T cells in-vivo: A novel concept for a potential feasible cure of demyelinating diseases
Published version of a preprint
Abstract
Chimeric antigen receptor (CAR) regulatory T cell (Treg) therapy has approved promising in murine experiments. It comprises from ex-vivo introduction of CARs to the Tregs of the recipient, and infusing them back thereafter. This process requires enormous amounts of equipment and expertise and therefore, cannot be considered feasible for people with demyelinating diseases, even if it proves to be effective and safe in the future. The presented novel concept introduces feasibility to CAR Treg therapy, by shifting most of the ex-vivo processes in-vivo. Inter-disciplinary discussions on such concepts is encouraged among experts in different fields.
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Cites
Highly accurate protein structure prediction with AlphaFold
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Accurate prediction of protein structures and interactions using a 3-track network
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Plasticity of CD4+ T Cell Lineage Differentiation
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CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
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Research works printed but not linked: 3
- Korn, 2007, Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation, Nat. Med., 13, 423, 10.1038/nm1564 · DOI
- Mohseni, 2020, The Future of Regulatory T Cell Therapy: promises and Challenges of Implementing CAR Technology, Front. Immunol., 11, 1608, 10.3389/fimmu.2020.01608 · DOI
- Shevyrev, D. & Tereshchenko, V. 2020. Treg Heterogeneity, Function, and Homeostasis. Front. Immunol., 10. · DOI
Metadata
- Authors
- Sedaghat, N., & Etemadifar, M.
- Affiliations
- Isfahan University of Medical Sciences (IR)
- Corresponding author
- Sedaghat, Nahad
- Venue
- Multiple Sclerosis and Related Disorders
- Publisher
- Elsevier BV
- Published
- 2022-01
- Volume
- 57
- Pages
- 103341
- ISSN
- 2211-0348 (ISSN-L)
- OpenAlex
- W3206819064
- Cited by
- 13
- References
- 6
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 1
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Multiple Sclerosis and Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- chimeric antigen receptor, regulatory T cells, demyelinating disease, multiple sclerosis
- MeSH terms
- Receptors, Chimeric Antigen, Animals, Demyelinating Diseases, Humans, Receptors, Antigen, T-Cell, Immunotherapy, Adoptive, T-Lymphocytes, Regulatory, Mice
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