Cited by 32Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliverySurfactants and Colloidal Systems

Self-assembled nanomicelles of damnacanthal-loaded amphiphilic modified chitosan: Preparation, characterization and cytotoxicity study

Sukamporn, Pakin, Baek, Seung Joon, Gritsanapan, Wandee, Chirachanchai, Suwabun, Nualsanit, Thararat, Rojanapanthu, Pleumchitt·2017·Materials Science and Engineering C

Abstract

Damnacanthal (Dam) is a phytochemical with many pharmacological properties including anticancer activity. However, its hydrophobicity, poor bioavailability and stability limit its application in many biological approaches. In this study, Dam nanomicelles as an emerging platform were developed to overcome limitations. The deoxycholic and poly(ethylene glycol) methyl ether grafted chitosan (DCA-CS-mPEG) was synthesized and characterized by FTIR and 1 H NMR and the degree of substitution (DS) was determined by elemental analysis (EA). This polymer formed self-assembled micelles with a core-shell structure and a critical micelle concentration (CMC) of 37.2μg/mL. Dam-loaded polymeric micelles were prepared by dialysis method and characterized by DLS, TEM, FTIR, DSC and HPLC. The mean particle size of Dam-loaded micelles was about 200nm with spherical shape. The drug entrapment efficiency was up to 57.7%. FTIR and DSC analysis revealed that Dam was entrapped in the micelles in the amorphous state. The in vitro release profiles of Dam from micelles were sustained release and pH-sensitive behavior. Cytotoxic studies exhibited the comparable efficacy and safety of this delivery system. Overall these results indicate the possible utilization of DCA-CS-mPEG micelles as a promising carrier for hydrophobic compounds like Dam.

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Crossref · 10.1016/j.msec.2017.03.263

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  • PNMs can encapsulate poorly soluble pharmaceuticals and enhance their biological behavior.

    “Moreover, PNMs can encapsulate poorly soluble pharmaceuticals and enhance their biological behavior [44,45].”

    From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [45]

  • Polymeric micelles with high stability have shown good biocompatibility in cancer therapy applications.

    “As reported, polymeric micelles with high stability have shown good biocompatibility in cancer therapy applications.”

    From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [45]

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Authors
Sukamporn, P., Baek, S. J., Gritsanapan, W., Chirachanchai, S., Nualsanit, T., & Rojanapanthu, P.
Affiliations
  • Mahidol University (TH)
  • Seoul National University (KR)
  • Chulalongkorn University (TH)
  • Thammasat University (TH)
Corresponding author
Rojanapanthu, Pleumchitt
Venue
Materials Science and Engineering C
Publisher
Elsevier BV
Published
2017-08
Volume
77
Pages
1068-1077
ISSN
0928-4931 (ISSN-L)
OpenAlex
W2604349539
Cited by
32
References
50
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 3
FWCI
1.83
Type
journal article
Language
en
Open access
closed
Locations
  • Materials Science and Engineering C (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Thailand Research Fund
  • Mahidol University (IRG5780007)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
Keywords
damnacanthal, polymeric micelles, chitosan, deoxycholic acid, poly(ethylene glycol) methyl ether, amphiphilic polymers, self-assembly, drug delivery, hydrophobic drug encapsulation, encapsulation efficiency, sustained drug release, pH-dependent release, cytotoxicity, anticancer phytochemicals
MeSH terms
Anthraquinones, Drug Carriers, Micelles, Particle Size, Polyethylene Glycols, Polymers, Chitosan, Nanostructures

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