Self-assembled nanomicelles of damnacanthal-loaded amphiphilic modified chitosan: Preparation, characterization and cytotoxicity study
Abstract
Damnacanthal (Dam) is a phytochemical with many pharmacological properties including anticancer activity. However, its hydrophobicity, poor bioavailability and stability limit its application in many biological approaches. In this study, Dam nanomicelles as an emerging platform were developed to overcome limitations. The deoxycholic and poly(ethylene glycol) methyl ether grafted chitosan (DCA-CS-mPEG) was synthesized and characterized by FTIR and 1 H NMR and the degree of substitution (DS) was determined by elemental analysis (EA). This polymer formed self-assembled micelles with a core-shell structure and a critical micelle concentration (CMC) of 37.2μg/mL. Dam-loaded polymeric micelles were prepared by dialysis method and characterized by DLS, TEM, FTIR, DSC and HPLC. The mean particle size of Dam-loaded micelles was about 200nm with spherical shape. The drug entrapment efficiency was up to 57.7%. FTIR and DSC analysis revealed that Dam was entrapped in the micelles in the amorphous state. The in vitro release profiles of Dam from micelles were sustained release and pH-sensitive behavior. Cytotoxic studies exhibited the comparable efficacy and safety of this delivery system. Overall these results indicate the possible utilization of DCA-CS-mPEG micelles as a promising carrier for hydrophobic compounds like Dam.
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PNMs can encapsulate poorly soluble pharmaceuticals and enhance their biological behavior.
“Moreover, PNMs can encapsulate poorly soluble pharmaceuticals and enhance their biological behavior [44,45].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [45]
Polymeric micelles with high stability have shown good biocompatibility in cancer therapy applications.
“As reported, polymeric micelles with high stability have shown good biocompatibility in cancer therapy applications.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [45]
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Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works
“Moreover, PNMs can encapsulate poorly soluble pharmaceuticals and enhance their biological behavior [44,45].”
Background
- Authors
- Sukamporn, P., Baek, S. J., Gritsanapan, W., Chirachanchai, S., Nualsanit, T., & Rojanapanthu, P.
- Affiliations
- Mahidol University (TH)
- Seoul National University (KR)
- Chulalongkorn University (TH)
- Thammasat University (TH)
- Corresponding author
- Rojanapanthu, Pleumchitt
- Venue
- Materials Science and Engineering C
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 77
- Pages
- 1068-1077
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2604349539
- Cited by
- 32
- References
- 50
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 3
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Materials Science and Engineering C (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Thailand Research Fund
- Mahidol University (IRG5780007)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
- Keywords
- damnacanthal, polymeric micelles, chitosan, deoxycholic acid, poly(ethylene glycol) methyl ether, amphiphilic polymers, self-assembly, drug delivery, hydrophobic drug encapsulation, encapsulation efficiency, sustained drug release, pH-dependent release, cytotoxicity, anticancer phytochemicals
- MeSH terms
- Anthraquinones, Drug Carriers, Micelles, Particle Size, Polyethylene Glycols, Polymers, Chitosan, Nanostructures
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