Chitooligosaccharides for wound healing biomaterials engineering
Open accessAbstract
Chitooligosaccharides (CHOS) are oligomers of β-(1-4) linked N-acetylglucosamine and D-glucosamine that are produced from chitin or chitosan using different enzymatic or chemical methods. CHOS are water-soluble and non-cytotoxic with diverse bioactivities such as antibacterial, anti-inflammation, anti-obesity, anti-tumor and antioxidant. These biological features make CHOS promising compounds for several medical and food applications. In this review, we critically summarize the biological activities of CHOS in biomaterials engineering with a particular focus on CHOS applications for skin tissue healing and regeneration. We also present an updated overview of CHOS fabrications into wound dressing biomaterials for several in vitro and in vivo studies.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
α-Chitosan, derived from crustacean shells, has an anti-parallel polymer arrangement, resulting in high crystallinity and mechanical strength.
“α-Chitosan, derived from crustacean shells, has an anti-parallel polymer arrangement, resulting in high crystallinity and mechanical strength [154,155].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [155]
Cites
Chitosan: an update on potential biomedical and pharmaceutical applications.
Cheung, R., Ng, T., Wong, J., & Chan, W. (2015) · Marine Drugs · doi:10.3390/md13085156 · Cited by 1,297 · see citing works
Sindrilaru, A., Peters, T., Wieschalka, S., Baican, C., Baican, A., Peter, H., Hainzl, A., Schatz, S., Qi, Y., Schlecht, A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44490 · Cited by 1,100 · see citing works
Van De Water, L., Varney, S., & Tomasek, J. J. (2013) · Advances in Wound Care · doi:10.1089/wound.2012.0393 · Cited by 251 · see citing works
Chitin oligosaccharides inhibit oxidative stress in live cells
Ngo, D.-N., Kim, M.-M., & Kim, S.-K. (2008) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2008.02.005 · Cited by 163 · see citing works
Reduced Il17a Expression Distinguishes a Ly6cloMHCIIhi Macrophage Population Promoting Wound Healing
Rodero, M. P., Hodgson, S. S., Hollier, B., Combadiere, C., & Khosrotehrani, K. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.368 · Cited by 104 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- Jafari, H., Bernaerts, K. V., Dodi, G., & Shavandi, A.
- Affiliations
- Université Libre de Bruxelles (BE)
- Maastricht University (NL)
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- Corresponding author
- Shavandi, Amin
- Venue
- Materials Science and Engineering: C
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 117
- Pages
- 111266
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W3045419937
- Cited by
- 80
- References
- 5
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 9 · 2023: 11 · 2022: 25 · 2021: 12 · 2020: 5
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Materials Science and Engineering C (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- Funders
- Innoviris Brussels
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Studies on Chitinases and Chitosanases
- Physical Sciences › Materials Science › Biomaterials › Nanocomposite Films for Food Packaging
- Keywords
- chitooligosaccharides, wound healing, wound dressings, skin regeneration, chitosan, chitin, enzymatic hydrolysis, chemical modification, antibacterial activity, anti-inflammatory activity, antioxidant activity, biomaterials
- MeSH terms
- Biocompatible Materials, Chitin, Oligosaccharides, Wound Healing, Chitosan
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
