Reduced Il17a Expression Distinguishes a Ly6cloMHCIIhi Macrophage Population Promoting Wound Healing
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Macrophages are the main components of inflammation during skin wound healing. They are critical in wound closure and in excessive inflammation, resulting in defective healing observed in chronic wounds. Given the heterogeneity of macrophage phenotypes and functions, we here hypothesized that different subpopulations of macrophages would have different and sometimes opposing effects on wound healing. Using multimarker flow cytometry and RNA expression array analyses on macrophage subpopulations from wound granulation tissue, we identified a Ly6c(lo)MHCII(hi) "noninflammatory" subset that increased both in absolute number and proportion during normal wound healing and was missing in Ob/Ob and MYD88-/- models of delayed healing. We also identified IL17 as the main cytokine distinguishing this population from proinflammatory macrophages and demonstrated that inhibition of IL17 by blocking Ab or in IL17A-/- mice accelerated normal and delayed healing. These findings dissect the complexity of the role and activity of the macrophages during wound inflammation and may contribute to the development of therapeutic approaches to restore healing in chronic wounds.
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A persistent proinflammatory wound macrophage phenotype has been observed in diabetic humans and mice and in chronic venous ulcers.
“We and others have observed a persistent proinflammatory wound Mp phenotype in diabetic humans and mice (14,29) and in chronic venous ulcers (30).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [29]
Recent studies have shown that macrophage phenotypes change over the different phases of tissue repair and that the sequential appearance of these phenotypes may be required for efficient repair.
“Recent studies have shown that Mp phenotypes change over the different phases of tissue repair and that the sequential appearance of these phenotypes may be required for efficient repair (11,14,29,49,50).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [29]
Either premature changes in phenotype or delayed/impaired changes in phenotype have been associated with impaired healing.
“In fact, either premature changes in phenotype or delayed/impaired changes in phenotype have been associated with impaired healing (14,29,49).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [29]
Cites
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542 · see citing works
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189 · see citing works
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528 · see citing works
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,366 · see citing works
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358 · see citing works
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300 · see citing works
The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.
(1975) · PubMed Central · Cited by 1,437 · see citing works
Differential Roles of Macrophages in Diverse Phases of Skin Repair
Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., & Eming, S. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903356 · Cited by 1,205 · see citing works
Sindrilaru, A., Peters, T., Wieschalka, S., Baican, C., Baican, A., Peter, H., Hainzl, A., Schatz, S., Qi, Y., Schlecht, A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44490 · Cited by 1,100 · see citing works
Nakae, S., Komiyama, Y., Nambu, A., Sudo, K., Iwase, M., Homma, I., Sekikawa, K., Asano, M., & Iwakura, Y. (2002) · Immunity · doi:10.1016/s1074-7613(02)00391-6 · Cited by 1,053 · see citing works
Comparison of gene expression profiles between human and mouse monocyte subsets
Ingersoll, M. A., Spanbroek, R., Lottaz, C., Gautier, E. L., Frankenberger, M., Hoffmann, R. F. G., Lang, R., Haniffa, M. A., Collin, M. P., Tacke, F., et al. (2009) · Blood · doi:10.1182/blood-2009-07-235028 · Cited by 731 · see citing works
Combadière, C., Potteaux, S., Rodero, M., Simon, T., Pézard, A., Esposito, B., Merval, R., Proudfoot, A., Tedgui, A., & Mallat, Z. (2008) · Circulation · doi:10.1161/circulationaha.107.745091 · Cited by 714 · see citing works
Self-citationSelective and Specific Macrophage Ablation Is Detrimental to Wound Healing in Mice
Mirza, R., DiPietro, L. A., & Koh, T. J. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.090248 · Cited by 616 · see citing works
Chen, F., Liu, Z., Wu, W., Rozo, C. T., Bowdridge, S. A. A., Millman, A., van Rooijen, N., Urban, J. F., Wynn, T. A., & Gause, W. C. (2012) · Nature Medicine · doi:10.1038/nm.2628 · Cited by 451 · see citing works
Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology
Pello, Ó. M., Pizzol, M. D., Mirolo, M., Soucek, L., Zammataro, L. A., Amabile, A., Doni, A., Nebuloni, M., Swigart, L. B., Evan, G. I., et al. (2011) · Blood · doi:10.1182/blood-2011-02-339911 · Cited by 387 · see citing works
A Transgenic Mouse Model of Inducible Macrophage Depletion
Goren, I., Allmann, N., Yogev, N., Schürmann, C., Linke, A., Holdener, M., Waisman, A., Pfeilschifter, J. M., & Frank, S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081002 · Cited by 355 · see citing works
Dysregulation of monocyte/macrophage phenotype in wounds of diabetic mice
Mirza, R., & Koh, T. J. (2011) · Cytokine · doi:10.1016/j.cyto.2011.06.016 · Cited by 342 · see citing works
Skin wound healing modulation by macrophages.
Rodero, M. P., & Khosrotehrani, K. (2010) · PubMed Central · Cited by 326 · see citing works
Self-citationRoss, R., & Odland, G. F. (1968) · The Journal of Cell Biology · doi:10.1083/jcb.39.1.152 · Cited by 322 · see citing works
Semaphorin 7A initiates T-cell-mediated inflammatory responses through α1β1 integrin
Suzuki, K., Okuno, T., Yamamoto, M., Pasterkamp, R. J., Takegahara, N., Takamatsu, H., Kitao, T., Takagi, J., Rennert, P. D., Kolodkin, A. L., et al. (2007) · Nature · doi:10.1038/nature05652 · Cited by 309 · see citing works
IL-17-Producing Alveolar Macrophages Mediate Allergic Lung Inflammation Related to Asthma
Song, C., Luo, L., Zhang, L., Li, B., Liang, Z., Liu, G., Li, D., Zhang, G., Huang, B., & Feng, Z. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6117 · Cited by 301 · see citing works
Lai, J., Lai, K., Chuang, K., Chang, P., Yu, I.-C. I., Lin, W., & Chang, C. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39335 · Cited by 212 · see citing works
CD169+ macrophages at the crossroads of antigen presentation
Martínez‐Pomares, L., & Gordon, S. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.11.001 · Cited by 199 · see citing works
Werner, J. L., Gessner, M. A., Lilly, L. M., Nelson, M. P., Metz, A. E., Horn, D., Dunaway, C. W., Deshane, J. S., Chaplin, D., Weaver, C. T., et al. (2011) · Infection and Immunity · doi:10.1128/iai.05493-11 · Cited by 174 · see citing works
Fantuzzi, L., Borghi, P., Ciolli, V., Pavlakis, G. N., Belardelli, F., & Gessani, S. (1999) · Blood · doi:10.1182/blood.v94.3.875.415k28_875_883 · Cited by 171 · see citing works
Wound Healing Is Impaired in MyD88-Deficient Mice
Macedo, L., Pinhal‐Enfield, G., Alshits, V., Elson, G., Cronstein, B. N., & Leibovich, S. J. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061048 · Cited by 153 · see citing works
Goren, I., Müller, E., Schiefelbein, D., Christen, U., Pfeilschifter, J., Mühl, H., & Frank, S. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700842 · Cited by 151 · see citing works
Animal models of wound repair: Are they cutting it?
Ansell, D., Holden, K., & Hardman, M. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01540.x · Cited by 144 · see citing works
Suzuki, M., Tachibana, I., Takeda, Y., He, P., Minami, S., Iwasaki, T., Kida, H., Goya, S., Kijima, T., Yoshida, M., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802797 · Cited by 103 · see citing works
The NKG2D receptor: immunobiology and clinical implications
Burgess, S. J., Maasho, K., Masilamani, M., Narayanan, S., Borrego, F., & Coligan, J. E. (2007) · Immunologic Research · doi:10.1007/s12026-007-0060-9 · Cited by 98 · see citing works
Cochain, C., Rodero, M. P., Vilar, J., Récalde, A., Richart, A. L., Loinard, C., Zouggari, Y., Guérin, C. L., Duriez, M., Combadière, B., et al. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq153 · Cited by 79 · see citing works
Self-citationNassar, D., Droitcourt, C., d’Argent, E. M., Kim, M. J., Khosrotehrani, K., & Aractingi, S. (2011) · The FASEB Journal · doi:10.1096/fj.11-180695 · Cited by 70 · see citing works
Self-citationAnti-cytokine therapies for psoriasis
Nograles, K. E., & Krueger, J. G. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.01.024 · Cited by 57 · see citing works
Kato, T., Saeki, H., Tsunemi, Y., Shibata, S., Tamaki, K., & Sato, S. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01286.x · Cited by 31 · see citing works
Saether, P. C., Westgaard, I. H., Hoelsbrekken, S. E., Benjamin, J., Lanier, L. L., Fossum, S., & Dissen, E. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3177 · Cited by 27 · see citing works
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Macrophages: versatile players in renal inflammation and fibrosis
Tang, P. M.-K., Nikolic-Paterson, D. J., & Lan, H.-Y. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0110-2 · Cited by 1,033 · see citing works
Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing
Hesketh, M., Sahin, K. B., West, Z. E., & Murray, R. Z. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071545 · Cited by 852 · see citing works
Ellis, S., Lin, E. J., & Tartar, D. (2018) · Current Dermatology Reports · doi:10.1007/s13671-018-0234-9 · Cited by 625 · see citing works
Macrophages as a therapeutic target to promote diabetic wound healing
Sharifiaghdam, M., Shaabani, E., Majidi, R. F., Smedt, S. C. D., Braeckmans, K., & Fraire, J. C. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.07.016 · Cited by 596 · see citing works
Skin Wound Healing: Normal Macrophage Function and Macrophage Dysfunction in Diabetic Wounds
Aitcheson, S. M., Frentiu, F. D., Hurn, S. E., Edwards, K. P., & Murray, R. Z. (2021) · Molecules · doi:10.3390/molecules26164917 · Cited by 445 · see citing works
Macrophage-Mediated Inflammation in Skin Wound Healing
Hassanshahi, A., Moradzad, M., Ghalamkari, S., Fadaei, M., Cowin, A. J., & Hassanshahi, M. (2022) · Cells · doi:10.3390/cells11192953 · Cited by 375 · see citing works
Phenotypic transitions of macrophages orchestrate tissue repair.
Novak, M. L., & Koh, T. (2013) · American Journal of Pathology · doi:10.1016/j.ajpath.2013.06.034 · Cited by 332 · see citing works
Mirza, R. E., Fang, M. M., Weinheimer-Haus, E. M., Ennis, W. J., & Koh, T. J. (2014) · Diabetes · doi:10.2337/db13-0927 · Cited by 319 · see citing works
Macrophage-based therapeutic strategies in regenerative medicine
Spiller, K. L., & Koh, T. J. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.05.010 · Cited by 308 · see citing works
Dermal adipocyte lipolysis and myofibroblast conversion are required for efficient skin repair
Shook, B. A., Wasko, R. R., Mano, O., Rutenberg-Schoenberg, M. L., Rudolph, M. C., Zirak, B., Rivera-Gonzalez, G. C., López-Giráldez, F., Zarini, S., Rezza, A., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.03.013 · Cited by 265 · see citing works
Macrophages: A review of their role in wound healing and their therapeutic use
Snyder, R. J., Lantis, J., Kirsner, R. S., Shah, V., Molyneaux, M., & Carter, M. J. (2016) · Wound Repair and Regeneration · doi:10.1111/wrr.12444 · Cited by 245 · see citing works
The balancing act of the liver: tissue regeneration versus fibrosis
Cordero-Espinoza, L., & Huch, M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93562 · Cited by 220 · see citing works
CD301b+ Macrophages Are Essential for Effective Skin Wound Healing
Shook, B. A., Xiao, E.-C., Kumamoto, Y., Iwasaki, A., & Horsley, V. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.05.107 · Cited by 167 · see citing works
Macrophage-mediated inflammation in diabetic wound repair
Wolf, S., Melvin, W., & Gallagher, K. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.06.013 · Cited by 165 · see citing works
Macrophage PPARγ and impaired wound healing in type 2 diabetes
Mirza, R. E., Fang, M. M., Novak, M. L., Urao, N., Sui, A., Ennis, W. J., & Koh, T. J. (2015) · The Journal of Pathology · doi:10.1002/path.4548 · Cited by 177 · see citing works
Brockmann, L., Giannou, A. D., Gagliani, N., & Huber, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18051033 · Cited by 143 · see citing works
Patel, J., Seppanen, E. J., Rodero, M. P., Wong, H. Y., Donovan, P., Neufeld, Z., Fisk, N. M., François, M., & Khosrotehrani, K. (2016) · Circulation · doi:10.1161/circulationaha.116.024754 · Cited by 127 · see citing works
Self-citationAn overview of the therapeutic potential of regenerative medicine in cutaneous wound healing
Pang, C., Ibrahim, A., Bulstrode, N. W., & Ferretti, P. (2017) · International Wound Journal · doi:10.1111/iwj.12735 · Cited by 113 · see citing works
Cheng, M. L., Nakib, D., Perciani, C. T., & MacParland, S. A. (2021) · Clinical Science · doi:10.1042/cs20190654 · Cited by 122 · see citing works
Macrophage regulation of angiogenesis in health and disease.
Martin, P., & Gurevich, D. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.06.010 · Cited by 102 · see citing works
Macrophage polarity and wound age determination
Kuninaka, Y., Ishida, Y., Ishigami, A., Nosaka, M., Matsuki, J., Yasuda, H., Kofuna, A., Kimura, A., Furukawa, F., & Kondo, T. (2022) · Scientific Reports · doi:10.1038/s41598-022-24577-9 · Cited by 89 · see citing works
Macrophages in Skin Wounds: Functions and Therapeutic Potential
Sim, S.-L., Kumari, S., Kaur, S., & Khosrotehrani, K. (2022) · Biomolecules · doi:10.3390/biom12111659 · Cited by 92 · see citing works
Self-citationChitooligosaccharides for wound healing biomaterials engineering
Jafari, H., Bernaerts, K. V., Dodi, G., & Shavandi, A. (2020) · Materials Science and Engineering: C · doi:10.1016/j.msec.2020.111266 · Cited by 80 · see citing works
Macrophages – sensors and effectors coordinating skin damage and repair
Willenborg, S., & Eming, S. A. (2014) · Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · doi:10.1111/ddg.12290 · Cited by 80 · see citing works
IL‐17A promotes neutrophilic inflammation and disturbs acute wound healing in skin
Takagi, N., Kawakami, K., Kanno, E., Tanno, H., Takeda, A., Ishii, K., Imai, Y., Iwakura, Y., & Tachi, M. (2017) · Experimental Dermatology · doi:10.1111/exd.13115 · Cited by 79 · see citing works
Zhang, D., Li, L.-J., Shan, Y.-H., Xiong, J., Hu, Z.-J., Zhang, Y., & Gao, J.-Q. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.04.021 · Cited by 69 · see citing works
Monocytes/Macrophages play a pathogenic role in IL-23 mediated psoriasis-like skin inflammation
Wang, Y., Edelmayer, R. M., Wetter, J., Salte, K. M., Gauvin, D. M., Leys, L. J., Paulsboe, S. E., Su, Z., Weinberg, I., Namovic, M. T., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-41655-7 · Cited by 75 · see citing works
Skin γδ T Cells and Their Function in Wound Healing
Hu, W., Shang, R., Yang, J., Chen, C., Liu, Z., Liang, G., He, W., & Luo, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.875076 · Cited by 72 · see citing works
IL-17 in wound repair: bridging acute and chronic responses
Mu, X., Gu, R., Tang, M., Wu, X., He, W., & Nie, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01668-w · Cited by 72 · see citing works
Lee, J. S., Rodero, M., Patel, J., Moi, D., Mazzieri, R., & Khosrotehrani, K. (2017) · The FASEB Journal · doi:10.1096/fj.201700773r · Cited by 62 · see citing works
Self-citationIn Vivo Imaging Reveals a Pioneer Wave of Monocyte Recruitment into Mouse Skin Wounds
Rodero, M., Licata, F., Poupel, L., Hamon, P., Khosrotehrani, K., Combadière, C., & Boissonnas, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108212 · Cited by 55 · see citing works
Self-citationYu, Q., Yan, Y., Huang, J. S., Liang, Q., Li, J., Wang, B., Ma, B., Bianco, A., Ge, S., & Shao, J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123149 · Cited by 61 · see citing works
Wounds under diabetic milieu: The role of immune cellar components and signaling pathways
Lin, S., Wang, Q., Huang, X., Feng, J., Wang, Y., Shao, T., Deng, X., Cao, Y., Chen, X.-H., Zhou, M., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114052 · Cited by 62 · see citing works
Kim, T. H., Jung, Y., & Kim, S. H. (2017) · Tissue Engineering Part A · doi:10.1089/ten.tea.2017.0318 · Cited by 60 · see citing works
Single‐cell deconstruction of post‐sepsis skeletal muscle and adipose tissue microenvironments
Cho, D. S., Schmitt, R. E., Dasgupta, A., Ducharme, A. M., & Doles, J. D. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12596 · Cited by 57 · see citing works
TLR3 drives IRF6‐dependent IL‐23p19 expression and p19/EBI3 heterodimer formation in keratinocytes
Ramnath, D., Tunny, K. A., Hohenhaus, D. M., Pitts, C. M., Bergot, A., Hogarth, P. M., Hamilton, J. A., Kapétanovic, R., Sturm, R. A., Scholz, G. M., et al. (2015) · Immunology and Cell Biology · doi:10.1038/icb.2015.77 · Cited by 57 · see citing works
Tanno, H., Kawakami, K., Kanno, E., Suzuki, A., Takagi, N., Yamamoto, H., Ishii, K., Imai, Y., Maruyama, R., & Tachi, M. (2017) · Wound Repair and Regeneration · doi:10.1111/wrr.12588 · Cited by 56 · see citing works
Li, Y., Wang, Y., Zhou, L., Liu, M., Liang, G., Yan, R., Jiang, Y., Hao, J., Zhang, X., Hu, X., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00240 · Cited by 53 · see citing works
Recent advances in strategies to target the behavior of macrophages in wound healing
Zheng, H., Cheng, X., Lü, J., Shan, S., Yang, J., & Zhou, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115199 · Cited by 53 · see citing works
Giraud, É., Leštinová, T., Derrick, T. R., Martín, O., Dillon, R. J., Volf, P., Müller, I., Bates, P. A., & Rogers, M. E. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006794 · Cited by 51 · see citing works
Interleukin-17: Potential Target for Chronic Wounds
Hadian, Y., Bagood, M. D., Dahle, S. E., Sood, A., & Isseroff, R. R. (2019) · Mediators of Inflammation · doi:10.1155/2019/1297675 · Cited by 50 · see citing works
Functions of Vγ4 T Cells and Dendritic Epidermal T Cells on Skin Wound Healing
Li, Y., Wu, J., Luo, G., & He, W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01099 · Cited by 50 · see citing works
Mesenchymal stem cell therapy in skin: why and what for?
Khosrotehrani, K. (2013) · Experimental Dermatology · doi:10.1111/exd.12141 · Cited by 49 · see citing works
Self-citationStachura, A., Khanna, I., Krysiak, P., Paskal, W., & Wlodarski, P. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158621 · Cited by 46 · see citing works
Nazari, M., Taremi, S., Elahi, R., Mostanadi, P., & Esmaeilzadeh, A. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10806-3 · Cited by 46 · see citing works
Patel, J., Baz, B., Wong, H. Y., Lee, J. S., & Khosrotehrani, K. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.12.004 · Cited by 44 · see citing works
Self-citationHandoko, H. Y., Rodero, M. P., Boyle, G. M., Ferguson, B., Engwerda, C., Hill, G., Konrad Muller, H., Khosrotehrani, K., & Walker, G. J. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.9 · Cited by 36 · see citing works
Self-citationZhao, H., Shang, L., Zhang, Y., Liang, Z., Wang, N., Zhang, Q., Gao, C., & Luo, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1344963 · Cited by 33 · see citing works
Lecron, J., Charreau, S., Jégou, J., Salhi, N., Petit-Paris, I., Guignouard, E., Burucoa, C., Favot, L., Bodet, C., Barra, A., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.984016 · Cited by 32 · see citing works
ST2 receptor invalidation maintains wound inflammation, delays healing and increases fibrosis
Lee, J. S., Seppanen, E. J., Patel, J., Rodero, M. P., & Khosrotehrani, K. (2015) · Experimental Dermatology · doi:10.1111/exd.12833 · Cited by 30 · see citing works
Self-citationWee, J. W. K., Low, Z. S., Ooi, C. K., Henategala, B. P., Lim, Z. G. R., Yip, Y. S., Vos, M. I. G., Tan, W., Cheng, H. S., & Tan, N. S. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04638-7 · Cited by 29 · see citing works
Knockout of MicroRNA-155 Ameliorates the Th17/Th9 Immune Response and Promotes Wound Healing
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The systematic regulation of oyster CgIL17-1 and CgIL17-5 in response to air exposure
Xin, L., Zhang, H., Du, X., Li, Y., Li, M., Wang, L., Wang, H., Qiu, L., & Song, L. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.06.001 · Cited by 26 · see citing works
Yang, X. W., Mathis, B. J., Huang, Y., Li, W., & Shi, Y. Q. (2021) · Journal of Diabetes Research · doi:10.1155/2021/7945117 · Cited by 25 · see citing works
Neuropeptide substance P: A promising regulator of wound healing in diabetic foot ulcers
Chen, J., Ye, P., Gu, R., Zhu, H., He, W., Mu, X., Wu, X., Pang, H., Han, F. Y., & Nie, X. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115736 · Cited by 23 · see citing works
Mon, H. H., Christo, S. N., Ndi, C. P., Jasieniak, M., Rickard, H., Hayball, J. D., Griesser, H. J., & Semple, S. J. (2015) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b00833 · Cited by 23 · see citing works
Villani, R. M., Hodgson, S., Legrand, J. M. D., Greaney, J., Wong, H. Y., Pichol-Thievend, C., Adolphe, C., Wainwight, B., François, M., & Khosrotehrani, K. (2017) · Development · doi:10.1242/dev.143917 · Cited by 22 · see citing works
Self-citationMiura, T., Kawakami, K., Kanno, E., Tanno, H., Tada, H., Sato, N., Airi, M., Yokoyama, R., Kawamura, K., Kitai, Y., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.10.015 · Cited by 21 · see citing works
Μaione, F., Iqbal, A. J., Raucci, F., Letek, M., Bauer, M., & D’Acquisto, F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02752 · Cited by 19 · see citing works
Serum interleukin‐17 as a novel biomarker in patients with acne vulgaris
Ebrahim, A. A., Mustafa, A. I., & Elabd, A. M. (2019) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12934 · Cited by 18 · see citing works
Mirzadegan, E., Golshahi, H., & Kazemnejad, S. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106595 · Cited by 18 · see citing works
Mobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials
Karkanitsa, M. L., Fathi, P., Ngo, T. B., & Sadtler, K. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.730938 · Cited by 18 · see citing works
Qin, X., Yuan, H., Zhang, M., Liu, C., Yan, R., Song, H., & Dai, Q. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140710 · Cited by 16 · see citing works
Talovic, M., Patel, K. H., Schwartz, M., Madsen, J., & Garg, K. (2019) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2933 · Cited by 16 · see citing works
G-protein-coupled receptor 84 regulates acute inflammation in normal and diabetic skin wounds
Cooper, P. O., Kleb, S. S., Noonepalle, S. K., Amuso, V. M., Varshney, R., Rudolph, M. C., Dhaliwal, T., Nguyen, D. V., Mazumder, M. F., Babirye, N. S., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114288 · Cited by 15 · see citing works
Anti-inflammatory properties of a wound dressing combination of zinc oxide and turmeric extract
Meizarini, A., Aryati, A., Riawan, W., & Puteri, A. (2018) · Veterinary World · doi:10.14202/vetworld.2018.25-29 · Cited by 15 · see citing works
Stefia, L., Lee, J. S., Patel, J., de Sousa, S. R., Legrand, J. M. D., Rodero, M., Burman, S., Linedale, R., Morrison, M., & Khosrotehrani, K. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.02.027 · Cited by 13 · see citing works
Self-citationZhu, X., Sun, Y., Mu, X. N., Guo, P., Gao, F., Zhang, J., Zhu, Y., Zhang, X., Chen, L., Ning, Z., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.01.054 · Cited by 14 · see citing works
The mutual regulation between γδ T cells and macrophages during wound healing
Hu, W., Zhang, X., Sheng, H., Liu, Z., Chen, Y., Huang, Y., He, W., & Luo, G. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad087 · Cited by 13 · see citing works
Lei, X.-X., Cheng, L., Yang, Y., Pang, M., Dong, Y.-Q., Zhu, X., Chen, C.-H., Yao, Z.-X., Wu, G., Cheng, B., et al. (2021) · Burns & Trauma · doi:10.1093/burnst/tkab033 · Cited by 12 · see citing works
Özturan, Y. A., & Akın, İ. (2025) · Cutaneous and Ocular Toxicology · doi:10.1080/15569527.2025.2485129 · Cited by 12 · see citing works
The Small Molecule NLRP3 Inflammasome Inhibitor MCC950 Does Not Alter Wound Healing in Obese Mice
Lee, J. S., Robertson, A. A. B., Cooper, M. A., & Khosrotehrani, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113289 · Cited by 12 · see citing works
Self-citationMargiotta, F. M., Michelucci, A., Fidanzi, C., Granieri, G., Salvia, G., Bevilacqua, M., Janowska, A., Dini, V., & Romanelli, M. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13144089 · Cited by 13 · see citing works
Ding, H., Wang, Y., Bai, R., Li, Q., Ren, B., Jin, J., Chen, M., & Xu, X. (2025) · Aesthetic Surgery Journal · doi:10.1093/asj/sjaf040 · Cited by 10 · see citing works
Beserra, F. P., Gushiken, L. F. S., Hussni, M. F., & Pellizzon, C. H. (2018) · Wound Healing - Current Perspectives · doi:10.5772/intechopen.81731 · Cited by 14 · see citing works
Melvin, W. J., Bauer, T. M., Mangum, K. D., Audu, C. O., Shadiow, J., Barrett, E. C., Joshi, A., Moon, J. Y., Bogle, R., Mazumder, P., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.179012 · Cited by 9 · see citing works
Chen, C., Cai, X., Liu, Z., Zhang, W., Yang, J., Tang, Y., Chen, Y., Huang, Y., Hu, W., Zhang, X., et al. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae175 · Cited by 8 · see citing works
IL-17 in skin infections and homeostasis
García-Patiño, M. G., Marcial-Medina, C., Ruiz-Medina, B. E., & Licona-Limón, P. (2024) · Clinical Immunology · doi:10.1016/j.clim.2024.110352 · Cited by 7 · see citing works
Kurosaka, S., Tanno, H., Hirose, M., Kamada, W., Takayashiki, R., Sone, I., Sato, Y., Watanabe, T., Ishi, S., Shoji, M., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1550934 · Cited by 6 · see citing works
Rodero, M. P., Handoko, H. Y., Villani, R. M., Walker, G. J., & Khosrotehrani, K. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.78 · Cited by 6 · see citing works
Self-citationLu, Y., Xu, F., Qi, F., & Pan, Y. (2026) · Biomolecules · doi:10.3390/biom16030414 · Cited by 5 · see citing works
Manipulating the healing response
Azzimonti, B., Sabbatini, M., Rimondini, L., & Cannas, M. (2016) · Elsevier eBooks · doi:10.1016/b978-1-78242-455-0.00004-5 · Cited by 5 · see citing works
The significance of inflammasome activation during each phase of wound healing
Artlett, C. M. (2025) · Exploration of Medicine · doi:10.37349/emed.2025.1001326 · Cited by 4 · see citing works
Zhou, S., He, Y., Lin, J., Yang, F., Zhou, W., Cai, J., Liao, Y., & Lu, F. (2024) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000011743 · Cited by 4 · see citing works
Li, W., Xiong, F., Yao, C., Zhang, T., Zhou, L., Zhang, Z., Wang, Z., Mao, Y., Zhou, P., & Guan, J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13934 · Cited by 3 · see citing works
Huang, F., Ren, X., Yuan, B., Yang, W., Xu, L., Zhang, J., Zhang, H., Geng, M., Li, X., Zhang, F., et al. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0195 · Cited by 3 · see citing works
Dysregulated inflammation in diabetic wounds
denDekker, A., & Gallagher, K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816413-6.00005-8 · Cited by 2 · see citing works
Wu, M.-S., Shiue, S., Zheng, Q.-Y., Chen, Y.-S., & Lin, H.-Y. (2026) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-025-00786-x · Cited by 2 · see citing works
Potential Application of Plant-Derived Extracellular Vesicles in Treatment of Burn Wounds
He, X., Yang, Y., Niu, H., Hu, C., & Lin, J. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s563793 · Cited by 1 · see citing works
Macrophage‐Fibroblast Crosstalk Shapes Wound Repair Signaling In Vitro
Enriquez-Ochoa, D., Nagalla, R. R., Liu, Y., Guerrero‐Juarez, C. F., Atcha, H., Chang, G., Morales, N. A., Hooper, H. J., Cano, A. D., Lim, H. E., et al. (2026) · The FASEB Journal · doi:10.1096/fj.202601156r · Cited by 1 · see citing works
Kalshetti, D., Amin, M., Varsani, R., Narayanan, A., Ciurca, S., Grijalva, I., Lickfeld, A., Lukan, J. K., Schwaitzberg, S. D., & Arany, P. (2026) · Advances in Wound Care · doi:10.1177/21621918261450363 · Cited by 1 · see citing works
Crane, M., & Albina, J. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1311-4_12 · Cited by 1 · see citing works
Role of macrophages in systemic inflammation: wound healing
Ahmed, M. S., Rahman, M., Matin, M. A., Hossen, M. J., & Sikder, M. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822368-0.00015-3 · Cited by 1 · see citing works
Cox, C., Fry, K., Sivakumaran, Y., Spelman, L. J., & Khosrotehrani, K. (2023) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.19041 · Cited by 1 · see citing works
Self-citationTopical Anti-inflammatory Agents in Wound Care
Chiricozzi, A., & Romanelli, M. (2020) · Updates in clinical dermatology · doi:10.1007/978-3-030-28872-3_6 · Cited by 1 · see citing works
He, W., Cai, X., Liu, Z., Zhang, W., Yang, J., Tang, Y., Chen, Y., Huang, Y., Hu, W., Zhang, X., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3609946/v1 · Cited by 1 · see citing works
The role of Angiopoietin-like protein 4 in macrophage activation
Wee, J. W. K. (2020) · doi:10.32657/10356/151419
Kidney—Inflammation and remodeling
Steiger, S., Lichtnekert, J., & Anders, H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821385-8.00003-2
Şengül, F., Akyürek, F., Akyürek, F. T., & Kurtipek, G. S. (2026) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-026-04287-1
- Authors
- Rodero, M. P., Hodgson, S. S., Hollier, B., Combadiere, C., & Khosrotehrani, K.
- Affiliations
- The University of Queensland (AU)
- Queensland University of Technology (AU)
- Corresponding author
- Khosrotehrani, Kiarash
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 133
- Issue
- 3
- Pages
- 783-792
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1540897100
- Cited by
- 104
- References
- 36
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 12 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 4
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Faculty of Health; Institute of Health and Biomedical Innovation
- Funders
- University of Queensland
- National Health and Medical Research Council (1023371)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
- Keywords
- macrophage heterogeneity, wound healing, chronic wounds, IL-17A, IL-17, Ly6C, MHC class II, granulation tissue, delayed wound healing, ob/ob mice, MyD88 knockout mice, skin inflammation
- MeSH terms
- Animals, Antibodies, Histocompatibility Antigens Class II, Antigens, Ly, Bone Marrow Cells, Cell Differentiation, Female, Macrophages, Male, Mice, Inbred C57BL, Mice, Obese, Wound Healing, Mice, Knockout, Interleukin-17, Leptin, Models, Animal, Mice, Myeloid Differentiation Factor 88
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