Cited by 163Nanocomposite Films for Food PackagingStudies on Chitinases and ChitosanasesPolysaccharides Composition and Applications

Chitin oligosaccharides inhibit oxidative stress in live cells

Ngo, Dai-Nghiep, Kim, Moon-Moo, Kim, Se-Kwon·2008·Carbohydrate Polymers

Abstract

The aim of this research is to identify the cellular antioxidant effects of chitin oligosaccharides (NA-COS; M(w) 229.21-593.12 Da) produced by acidic hydrolysis of crab chitin. The inhibitory effect of NA-COS on myeloperoxidase (MPO) activity in human myeloid cells (HL-60) and oxidation of DNA and protein in mouse macrophages (Raw 264.7) were identified. Furthermore, their direct radical scavenging effect by 2',7'-dichlorofluorescein (DCF) intensity and intracellular glutathione (GSH) level were significantly increased in a time dependent manner, respectively. These results suggest that NA-COS act as a potent antioxidant in live cells.

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Crossref · 10.1016/j.carbpol.2008.02.005

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27 of 27 references verified0 citation errors · 0 not checkable

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Authors
Ngo, D.-N., Kim, M.-M., & Kim, S.-K.
Affiliations
  • Pukyong National University (KR)
  • Dong-Eui University (KR)
Corresponding author
  • Kim, Moon-Moo
  • Kim, Se-Kwon
Venue
Carbohydrate Polymers
Publisher
Elsevier BV
Published
2008-10
Volume
74
Issue
2
Pages
228-234
ISSN
0144-8617 (ISSN-L)
OpenAlex
W2037747961
Cited by
163
References
29
Citations by year
2026: 4 · 2025: 6 · 2024: 3 · 2023: 9 · 2022: 8 · 2021: 17 · 2020: 17 · 2019: 10 · 2018: 8 · 2017: 8 · 2016: 7 · 2015: 11 · 2014: 8 · 2013: 8 · 2012: 15
FWCI
3.43
Type
journal article
Language
en
Open access
closed
Locations
Carbohydrate Polymers (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanocomposite Films for Food Packaging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Studies on Chitinases and Chitosanases
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Keywords
chitin oligosaccharides, antioxidant activity, oxidative stress, myeloperoxidase inhibition, DNA oxidation, protein oxidation, free radical scavenging, glutathione, acid hydrolysis, HL-60 cells, RAW 264.7 macrophages

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