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A highly stretchable smart dressing for wound infection monitoring and treatment
Open accessAbstract
Smart dressings integrated with bioelectronics have attracted considerable attention and become promising solutions for skin wound management. However, due to the mechanical distinction between human body and the interface of electronics, previous smart dressings often suffered obvious degradation in electrical performance when attached to the soft and curvilinear wound sites. Here, we report a stretchable dressing integrated with temperature and pH sensor for wound status monitoring, as well as an electrically controlled drug delivery system for infection treatment. The wound dressing was featured with the deployment of liquid metal for seamless connection between rigid electrical components and gold particle-based electrodes, achieving a stretchable soft-hard interface. Stretching tests showed that both the sensing system and drug delivery system exhibited good stretchability and long-term stable conductivity with the resistance change rate less than 6 % under 50 % strain. Animal experiments demonstrated that the smart dressing was capable of detecting bacterial infection via the biomarkers of temperature and pH value and the infection factors of wound were significantly improved with therapy through electrically controlled antibiotics releasing. This proof-of-concept prototype has potential to significantly improve management of the wound, especially those with dynamic strain.
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Metadata
- Authors
- Su, R., Wang, L., Han, F., Bian, S., Meng, F., Qi, W., Zhai, X., Li, H., Wu, J., Pan, X., Pan, H., Guo, P., Lu, W. W., Liu, Z., & Zhao, X.
- Affiliations
- Qingdao University (CN)
- Chinese Academy of Sciences (CN)
- University of Hong Kong (HK)
- Nankai University (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Southern Medical University (CN)
- Shenzhen University of Advanced Technology (CN)
- Corresponding author
- Liu, Zhiyuan
- Zhao, Xiaoli
- ORCID
- Venue
- Materials Today Bio
- Publisher
- Elsevier BV
- Published
- 2024-06
- Volume
- 26
- Pages
- 101107
- ISSN
- 2590-0064 (ISSN-L)
- PMC
- PMC11216007
- OpenAlex
- W4399267504
- Cited by
- 24
- References
- 1
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 1
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Materials Today Bio (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- National Natural Science Foundation of China (32201125)
- Basic and Applied Basic Research Foundation of Guangdong Province
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Nanomaterials and Printing Technologies
- Keywords
- smart wound dressings, stretchable electronics, wound infection monitoring, temperature sensing, pH sensing, liquid metal electrodes, antibiotic release, bacterial infection detection
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