The DOI matches its Crossref record.
Nano hemostat solution: immediate hemostasis at the nanoscale
Open accessAbstract
Hemostasis is a major problem in surgical procedures and after major trauma. There are few effective methods to stop bleeding without causing secondary damage. We used a self-assembling peptide that establishes a nanofiber barrier to achieve complete hemostasis immediately when applied directly to a wound in the brain, spinal cord, femoral artery, liver, or skin of mammals. This novel therapy stops bleeding without the use of pressure, cauterization, vasoconstriction, coagulation, or cross-linked adhesives. The self-assembling solution is nontoxic and nonimmunogenic, and the breakdown products are amino acids, which are tissue building blocks that can be used to repair the site of injury. Here we report the first use of nanotechnology to achieve complete hemostasis in less than 15 seconds, which could fundamentally change how much blood is needed during surgery of the future.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Hong, Y., Zhou, F., Hua, Y., Zhang, X., Ni, C., Pan, D., Zhang, Y., Jiang, D., Yang, L., Lin, Q., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10004-7 · Cited by 836
Self-citationAdvanced bioactive nanomaterials for biomedical applications
Zhao, Y., Zhang, Z., Pan, Z., & Liu, Y. (2021) · Exploration · doi:10.1002/exp.20210089 · Cited by 357
Engineered Hemostatic Biomaterials for Sealing Wounds
Montazerian, H., Davoodi, E., Baidya, A., Baghdasarian, S., Sarikhani, E., Meyer, C. E., Haghniaz, R., Badv, M., Annabi, N., Khademhosseini, A., et al. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c01015 · Cited by 291
Esch, M. B., Mahler, G. J., Stokol, T., & Shuler, M. L. (2014) · Lab Chip · doi:10.1039/c4lc00371c · Cited by 281
Self-Assembling Peptide EAK16 and RADA16 Nanofiber Scaffold Hydrogel
Gelain, F., Luo, Z., & Zhang, S. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00690 · Cited by 267
Self-citation
Metadata
- Authors
- Ellis-Behnke, R. G., Liang, Y.-X., Tay, D. K. C., Kau, P. W. F., Schneider, G. E., Zhang, S., Wu, W., & So, K.-F.
- Venue
- Nanomedicine: Nanotechnology, Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 2
- Issue
- 4
- Pages
- 207-215
- ISSN
- 1549-9634 (ISSN-L)
- OpenAlex
- W2164954153
- Cited by
- 269
- References
- 0
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Nano hemostat solution: immediate hemostasis at the nanoscale. https://app.cochat.ai/papers/10.1016/j.nano.2006.08.001
- The paper
- Ellis-Behnke, R. G., Liang, Y.-X., Tay, D. K. C., Kau, P. W. F., Schneider, G. E., Zhang, S., Wu, W., & So, K.-F. (2006). Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine: Nanotechnology, Biology and Medicine. https://doi.org/10.1016/j.nano.2006.08.001
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
