CoChat
Sign Up
Cited by 214Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryDrug Solubulity and Delivery Systems

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer

Jain, Anekant, Jain, Sanjay K., Ganesh, N., Barve, Jaya, Beg, Aadil M.·2010·Nanomedicine: Nanotechnology, Biology and Medicine
DOI 10.1016/j.nano.2009.03.002
Open this paper in CoChat — free account

Abstract

Hyaluronic acid-coupled chitosan nanoparticles bearing oxaliplatin (L-OHP) encapsulated in Eudragit S100-coated pellets were developed for effective delivery to colon tumors. The in vitro drug release was investigated using a USP dissolution rate test paddle-type apparatus in different simulated gastrointestinal tract fluids. In therapeutic experiments the pellets of free drug, and hyaluronic acid-coupled and uncoupled chitosan nanoparticles bearing L-OHP were administered orally at the dose of 10 mg L-OHP/kg body weight to tumor-bearing Balb/c mice. In vivo data showed that hyaluronic acid-coupled chitosan nanoparticles delivered 1.99 +/- 0.82 and 9.36 +/- 1.10 microg of L-OHP/g of tissue in the colon and tumor, respectively after 12 hours, reflecting its targeting potential to the colon and tumor. These drug delivery systems show relatively high local drug concentration in the colonic milieu and colonic tumors with prolonged exposure time, which provides a potential to enhance antitumor efficacy with low systemic toxicity for the treatment of colon cancer. From the clinical editor In this study, a nanoparticle system was developed to deliver oxaliplatin to colorectal tumors. In murine models, the drug delivery system showed relatively high local drug concentration in colonic tumors with prolonged exposure time, which provides a potential for enhanced antitumor efficacy with low systematic toxicity.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.nano.2009.03.002

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 35 references

Research works printed but not linked: 2

  1. Souder, 1995, Control of d-amphetamine sulphate sustained release capsule, Drug Standards, 26, 77
  2. Yu, 1999, Blend films of chitosan gelation, J Wuhan Univ (Nal Sci Ed), 45, 440

Cited by

Sorted by citations

Items 101–200 of 214

Related

See all

Metadata

Authors
Jain, A., Jain, S. K., Ganesh, N., Barve, J., & Beg, A. M.
Affiliations
  • Dr. Hari Singh Gour University (IN)
  • Jawaharlal Nehru Cancer Hospital and Research Centre (IN)
Corresponding author
Jain, Sanjay K.
ORCID
Venue
Nanomedicine: Nanotechnology, Biology and Medicine
Publisher
Elsevier BV
Published
2010-02
Volume
6
Issue
1
Pages
179-190
ISSN
1549-9634 (ISSN-L)
DOI
10.1016/j.nano.2009.03.002
OpenAlex
W2055089903
Cited by
214
References
35
Citations by year
2026: 8 · 2025: 8 · 2024: 9 · 2023: 16 · 2022: 13 · 2021: 19 · 2020: 20 · 2019: 15 · 2018: 14 · 2017: 14 · 2016: 13 · 2015: 22 · 2014: 14 · 2013: 8 · 2012: 12
FWCI
4.66
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Nanomedicine Nanotechnology Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords
oxaliplatin, colorectal cancer, hyaluronic acid, chitosan nanoparticles, Eudragit S100, colon-targeted drug delivery, oral drug delivery, colon-specific drug release, tumor targeting, nanoparticle drug delivery
MeSH terms
Oxaliplatin, Animals, Calorimetry, Differential Scanning, Humans, Hyaluronic Acid, Ligands, Organoplatinum Compounds, Radionuclide Imaging, Remission Induction, Tissue Distribution, X-Ray Diffraction, Colorectal Neoplasms, Drug Delivery Systems, Spectroscopy, Fourier Transform Infrared, HT29 Cells, Xenograft Model Antitumor Assays, Chitosan, Mice, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review