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Cited by 214Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryDrug Solubulity and Delivery Systems

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer

Jain, Anekant, Jain, Sanjay K., Ganesh, N., Barve, Jaya, Beg, Aadil M.·2010·Nanomedicine: Nanotechnology, Biology and Medicine
DOI 10.1016/j.nano.2009.03.002
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Abstract

Hyaluronic acid-coupled chitosan nanoparticles bearing oxaliplatin (L-OHP) encapsulated in Eudragit S100-coated pellets were developed for effective delivery to colon tumors. The in vitro drug release was investigated using a USP dissolution rate test paddle-type apparatus in different simulated gastrointestinal tract fluids. In therapeutic experiments the pellets of free drug, and hyaluronic acid-coupled and uncoupled chitosan nanoparticles bearing L-OHP were administered orally at the dose of 10 mg L-OHP/kg body weight to tumor-bearing Balb/c mice. In vivo data showed that hyaluronic acid-coupled chitosan nanoparticles delivered 1.99 +/- 0.82 and 9.36 +/- 1.10 microg of L-OHP/g of tissue in the colon and tumor, respectively after 12 hours, reflecting its targeting potential to the colon and tumor. These drug delivery systems show relatively high local drug concentration in the colonic milieu and colonic tumors with prolonged exposure time, which provides a potential to enhance antitumor efficacy with low systemic toxicity for the treatment of colon cancer. From the clinical editor In this study, a nanoparticle system was developed to deliver oxaliplatin to colorectal tumors. In murine models, the drug delivery system showed relatively high local drug concentration in colonic tumors with prolonged exposure time, which provides a potential for enhanced antitumor efficacy with low systematic toxicity.

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Crossref · 10.1016/j.nano.2009.03.002

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Research works printed but not linked: 2

  1. Souder, 1995, Control of d-amphetamine sulphate sustained release capsule, Drug Standards, 26, 77
  2. Yu, 1999, Blend films of chitosan gelation, J Wuhan Univ (Nal Sci Ed), 45, 440

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Metadata

Authors
Jain, A., Jain, S. K., Ganesh, N., Barve, J., & Beg, A. M.
Affiliations
  • Dr. Hari Singh Gour University (IN)
  • Jawaharlal Nehru Cancer Hospital and Research Centre (IN)
Corresponding author
Jain, Sanjay K.
ORCID
Venue
Nanomedicine: Nanotechnology, Biology and Medicine
Publisher
Elsevier BV
Published
2010-02
Volume
6
Issue
1
Pages
179-190
ISSN
1549-9634 (ISSN-L)
DOI
10.1016/j.nano.2009.03.002
OpenAlex
W2055089903
Cited by
214
References
35
Citations by year
2026: 8 · 2025: 8 · 2024: 9 · 2023: 16 · 2022: 13 · 2021: 19 · 2020: 20 · 2019: 15 · 2018: 14 · 2017: 14 · 2016: 13 · 2015: 22 · 2014: 14 · 2013: 8 · 2012: 12
FWCI
4.66
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Nanomedicine Nanotechnology Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords
oxaliplatin, colorectal cancer, hyaluronic acid, chitosan nanoparticles, Eudragit S100, colon-targeted drug delivery, oral drug delivery, colon-specific drug release, tumor targeting, nanoparticle drug delivery
MeSH terms
Oxaliplatin, Animals, Calorimetry, Differential Scanning, Humans, Hyaluronic Acid, Ligands, Organoplatinum Compounds, Radionuclide Imaging, Remission Induction, Tissue Distribution, X-Ray Diffraction, Colorectal Neoplasms, Drug Delivery Systems, Spectroscopy, Fourier Transform Infrared, HT29 Cells, Xenograft Model Antitumor Assays, Chitosan, Mice, Nanoparticles

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