Cited by 214Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryDrug Solubulity and Delivery Systems

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Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer

Jain, Anekant, Jain, Sanjay K., Ganesh, N., Barve, Jaya, Beg, Aadil M.·2010·Nanomedicine: Nanotechnology, Biology and Medicine

DOI 10.1016/j.nano.2009.03.002

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Abstract

Hyaluronic acid-coupled chitosan nanoparticles bearing oxaliplatin (L-OHP) encapsulated in Eudragit S100-coated pellets were developed for effective delivery to colon tumors. The in vitro drug release was investigated using a USP dissolution rate test paddle-type apparatus in different simulated gastrointestinal tract fluids. In therapeutic experiments the pellets of free drug, and hyaluronic acid-coupled and uncoupled chitosan nanoparticles bearing L-OHP were administered orally at the dose of 10 mg L-OHP/kg body weight to tumor-bearing Balb/c mice. In vivo data showed that hyaluronic acid-coupled chitosan nanoparticles delivered 1.99 +/- 0.82 and 9.36 +/- 1.10 microg of L-OHP/g of tissue in the colon and tumor, respectively after 12 hours, reflecting its targeting potential to the colon and tumor. These drug delivery systems show relatively high local drug concentration in the colonic milieu and colonic tumors with prolonged exposure time, which provides a potential to enhance antitumor efficacy with low systemic toxicity for the treatment of colon cancer. From the clinical editor In this study, a nanoparticle system was developed to deliver oxaliplatin to colorectal tumors. In murine models, the drug delivery system showed relatively high local drug concentration in colonic tumors with prolonged exposure time, which provides a potential for enhanced antitumor efficacy with low systematic toxicity.

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Authors: Jain, A., Jain, S. K., Ganesh, N., Barve, J., & Beg, A. M.
Affiliations: Dr. Hari Singh Gour University (IN)
Jawaharlal Nehru Cancer Hospital and Research Centre (IN)
Corresponding author: Jain, Sanjay K.
ORCID: Jain, Sanjay K.
Ganesh, N.
Venue: Nanomedicine: Nanotechnology, Biology and Medicine
Publisher: Elsevier BV
Published: 2010-02
Volume: 6
Issue: 1
Pages: 179-190
ISSN: 1549-9634 (ISSN-L)
DOI: 10.1016/j.nano.2009.03.002
OpenAlex: W2055089903
Cited by: 214
References: 35
Citations by year: 2026: 8 · 2025: 8 · 2024: 9 · 2023: 16 · 2022: 13 · 2021: 19 · 2020: 20 · 2019: 15 · 2018: 14 · 2017: 14 · 2016: 13 · 2015: 22 · 2014: 14 · 2013: 8 · 2012: 12
FWCI: 4.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Nanomedicine Nanotechnology Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords: oxaliplatin, colorectal cancer, hyaluronic acid, chitosan nanoparticles, Eudragit S100, colon-targeted drug delivery, oral drug delivery, colon-specific drug release, tumor targeting, nanoparticle drug delivery
MeSH terms: Oxaliplatin, Animals, Calorimetry, Differential Scanning, Humans, Hyaluronic Acid, Ligands, Organoplatinum Compounds, Radionuclide Imaging, Remission Induction, Tissue Distribution, X-Ray Diffraction, Colorectal Neoplasms, Drug Delivery Systems, Spectroscopy, Fourier Transform Infrared, HT29 Cells, Xenograft Model Antitumor Assays, Chitosan, Mice, Nanoparticles

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Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer

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