Nanoparticle-emitted light attenuates amyloid-β-induced superoxide and inflammation in astrocytes
Open accessAbstract
Alzheimer's disease (AD) is the sixth leading cause of age-related death with no effective intervention yet available. Our previous studies have demonstrated the potential efficacy of Low Level Laser Therapy (LLLT) in AD cell models by mitigating amyloid-β peptide (Aβ)-induced oxidative stress and inflammation. However, the penetration depth of light is still the major challenge for implementing LLLT in animal models and in the clinical settings. In this study, we present the potential of applying Bioluminescence Resonance Energy Transfer to Quantum Dots (BRET-Qdots) as an alternative near infrared (NIR) light source for LLLT. Our results show that BRET-Qdot-emitted NIR suppresses Aβ-induced oxidative stress and inflammatory responses in primary rat astrocytes. These data provide a proof of concept for a nanomedicine platform for LLLT.From the clinical editor Low Level Laser Therapy has already been demonstrated to mitigate amyloid-β peptide induced oxidative stress and inflammation, a key driver of Alzheimer's disease. The major issue in moving this forward from cell cultures to live animals and potentially to human subjects is light penetration depth. In this novel study, BRET-Qdots were used as an alternative near infrared light source with good efficacy, paving the way to the development of a nanomedicine platform.
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BRET-Qdots can overcome the problem of low light penetration into the brain.
“With the use of technology named “Bioluminescence Resonance Energy Transfer to Quantum Dots” (BRET-Qdots), this problem can be overcome.”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [113]
CdSe or CdTe quantum dots act as a source of near infra-red radiations and reduce amyloid plaque induced inflammation and oxidative stress in animal models.
“These CdSe or CdTe quantum dots act as a source of near infra-red radiations and reduce the amyloid plaque induced inflammation and oxidative stress in animal models.”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [113]
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Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease
Khan, S., Barve, K. H., & Kumar, M. S. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200528142429 · Cited by 820 · see citing works
“This low-level laser therapy (LLLT) can be further exploited to treat other diseases that involve inflammation and oxidative stress pathologies [113].”
Background
- Authors
- Bungart, B. L., Dong, L., Sobek, D., Sun, G. Y., Yao, G., & Lee, J. C.-M.
- Affiliations
- University of Missouri (US)
- Zymera (United States) (US)
- Corresponding author
- Lee, James C-M.
- Venue
- Nanomedicine: Nanotechnology, Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 10
- Issue
- 1
- Pages
- 15-17
- ISSN
- 1549-9634 (ISSN-L)
- PMC
- PMC3895489
- OpenAlex
- W1999255024
- Cited by
- 27
- References
- 10
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 1 · 2017: 5 · 2016: 4 · 2014: 2
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nanomedicine Nanotechnology Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R21AG032579)
- National Institute of Neurological Disorders and Stroke (R21NS052385)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Laser Applications in Dentistry and Medicine
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- low-level laser therapy, amyloid-beta, Alzheimer's disease, astrocytes, oxidative stress, inflammation, superoxide, bioluminescence resonance energy transfer, quantum dots, near-infrared light, light penetration depth, nanomedicine
- MeSH terms
- Alzheimer Disease, Animals, Astrocytes, Humans, Inflammation, Light, Amyloid beta-Peptides, Oxidative Stress, Low-Level Light Therapy, Quantum Dots, Nanomedicine, Rats, Nanoparticles, Bioluminescence Resonance Energy Transfer Techniques
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