Cited by 112Nerve injury and regenerationCellular Mechanics and InteractionsNeuroscience and Neural Engineering

The orientation of the neuronal growth process can be directed via magnetic nanoparticles under an applied magnetic field.

Riggio, Cristina, Calatayud, M. Pilar, Giannaccini, Martina, Sanz, Beatriz, Torres, Teobaldo E., Fernández-Pacheco, Rodrigo, Ripoli, Andrea, Ibarra, Manuel Ricardo +4 more·2014·Nanomedicine Nanotechnology Biology and Medicine

Abstract

There is a growing body of evidence indicating the importance of physical stimuli for neuronal growth and development. Specifically, results from published experimental studies indicate that forces, when carefully controlled, can modulate neuronal regeneration. Here, we validate a non-invasive approach for physical guidance of nerve regeneration based on the synergic use of magnetic nanoparticles (MNPs) and magnetic fields (Ms). The concept is that the application of a tensile force to a neuronal cell can stimulate neurite initiation or axon elongation in the desired direction, the MNPs being used to generate this tensile force under the effect of a static external magnetic field providing the required directional orientation. In a neuron-like cell line, we have confirmed that MNPs direct the neurite outgrowth preferentially along the direction imposed by an external magnetic field, by inducing a net angle displacement (about 30°) of neurite direction. From the clinical editor: This study validates that non-invasive approaches for physical guidance of nerve regeneration based on the synergic use of magnetic nanoparticles and magnetic fields are possible. The hypothesis was confirmed by observing preferential neurite outgrowth in a cell culture system along the direction imposed by an external magnetic field.

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Crossref · 10.1016/j.nano.2013.12.008

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Authors
Riggio, C., Calatayud, M. P., Giannaccini, M., Sanz, B., Torres, T. E., Fernández-Pacheco, R., Ripoli, A., Ibarra, M. R., Dente, L., Cuschieri, A., Goya, G. F., & Raffa, V.
Affiliations
  • Scuola Superiore Sant'Anna (IT)
  • Universidad de Zaragoza (ES)
  • University of Pisa (IT)
  • Fondazione Toscana Gabriele Monasterio (IT)
Venue
Nanomedicine Nanotechnology Biology and Medicine
Publisher
Elsevier BV
Published
2014-10
Volume
10
Issue
7
Pages
1549-1558
ISSN
1549-9634 (ISSN-L)
OpenAlex
W2087996477
Cited by
112
References
50
Citations by year
2026: 3 · 2025: 10 · 2024: 18 · 2023: 11 · 2022: 10 · 2021: 12 · 2020: 16 · 2019: 8 · 2018: 8 · 2017: 5 · 2016: 2 · 2015: 7 · 2014: 2
FWCI
2.44
Type
journal article
Language
en
Open access
closed
Locations
  • Nanomedicine Nanotechnology Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (acceptedVersion)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
  • Discovery Research Portal (University of Dundee) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Keywords
magnetic nanoparticles, magnetic guidance, neurite outgrowth, axon elongation, nerve regeneration, tensile force
MeSH terms
Animals, Magnetics, Microscopy, Electron, Scanning, Neurons, PC12 Cells, Microscopy, Electron, Transmission, Rats, Nanoparticles

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