The orientation of the neuronal growth process can be directed via magnetic nanoparticles under an applied magnetic field.
Abstract
There is a growing body of evidence indicating the importance of physical stimuli for neuronal growth and development. Specifically, results from published experimental studies indicate that forces, when carefully controlled, can modulate neuronal regeneration. Here, we validate a non-invasive approach for physical guidance of nerve regeneration based on the synergic use of magnetic nanoparticles (MNPs) and magnetic fields (Ms). The concept is that the application of a tensile force to a neuronal cell can stimulate neurite initiation or axon elongation in the desired direction, the MNPs being used to generate this tensile force under the effect of a static external magnetic field providing the required directional orientation. In a neuron-like cell line, we have confirmed that MNPs direct the neurite outgrowth preferentially along the direction imposed by an external magnetic field, by inducing a net angle displacement (about 30°) of neurite direction. From the clinical editor: This study validates that non-invasive approaches for physical guidance of nerve regeneration based on the synergic use of magnetic nanoparticles and magnetic fields are possible. The hypothesis was confirmed by observing preferential neurite outgrowth in a cell culture system along the direction imposed by an external magnetic field.
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Iron oxide nanoparticles conjugated to NGF apply magnetic tensile forces to induce directed neurite sprout in PC12 cells.
“Apply magnetic tensile forces to induce directed neurite sprout in PC12 cells”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Riggio et al., 2014
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Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs
Naqvi, S., Panghal, A., & Flora, S. J. S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00494 · Cited by 305 · see citing works
- Authors
- Riggio, C., Calatayud, M. P., Giannaccini, M., Sanz, B., Torres, T. E., Fernández-Pacheco, R., Ripoli, A., Ibarra, M. R., Dente, L., Cuschieri, A., Goya, G. F., & Raffa, V.
- Affiliations
- Scuola Superiore Sant'Anna (IT)
- Universidad de Zaragoza (ES)
- University of Pisa (IT)
- Fondazione Toscana Gabriele Monasterio (IT)
- ORCID
- Venue
- Nanomedicine Nanotechnology Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 10
- Issue
- 7
- Pages
- 1549-1558
- ISSN
- 1549-9634 (ISSN-L)
- OpenAlex
- W2087996477
- Cited by
- 112
- References
- 50
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 18 · 2023: 11 · 2022: 10 · 2021: 12 · 2020: 16 · 2019: 8 · 2018: 8 · 2017: 5 · 2016: 2 · 2015: 7 · 2014: 2
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanomedicine Nanotechnology Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (acceptedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- magnetic nanoparticles, magnetic guidance, neurite outgrowth, axon elongation, nerve regeneration, tensile force
- MeSH terms
- Animals, Magnetics, Microscopy, Electron, Scanning, Neurons, PC12 Cells, Microscopy, Electron, Transmission, Rats, Nanoparticles
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