Neuronal Intrinsic Mechanisms of Axon Regeneration

Liu, Kai; Tedeschi, Andrea; Park, Kevin Kyungsuk; He, Zhigang

doi:10.1146/annurev-neuro-061010-113723

Cited by 459Nerve injury and regenerationNeurogenesis and neuroplasticity mechanismsTraumatic Brain Injury and Neurovascular Disturbances

The DOI matches its Crossref record; 150 of the 151 references it cites were found in a registry or an index.

Neuronal Intrinsic Mechanisms of Axon Regeneration

Liu, Kai, Tedeschi, Andrea, Park, Kevin Kyungsuk, He, Zhigang·2011·Annual Review of Neuroscience

DOI 10.1146/annurev-neuro-061010-113723

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Abstract

Failure of axon regeneration after central nervous system (CNS) injuries results in permanent functional deficits. Numerous studies in the past suggested that blocking extracellular inhibitory influences alone is insufficient to allow the majority of injured axons to regenerate, pointing to the importance of revisiting the hypothesis that diminished intrinsic regenerative ability critically underlies regeneration failure. Recent studies in different species and using different injury models have started to reveal important cellular and molecular mechanisms within neurons that govern axon regeneration. This review summarizes these observations and discusses possible strategies for stimulating axon regeneration and perhaps functional recovery after CNS injury.

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Many studies have identified molecules that block axonal sprouting after CNS injury, such as myelin proteins or chondroitin sulfate proteoglycans.
“There have been many studies of the molecules that block axonal sprouting after CNS injury, such as myelin proteins or chondroitin sulfate proteoglycans (CSPGs)8–10”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]
Much scientific study has focused on the molecular components of the injury response that block axonal sprouting, such as the glial growth inhibitors NogoA and the chondroitin sulfate proteoglycans.
“Much scientific study has focused on the molecular components of the injury response that block axonal sprouting, such as the glial growth inhibitors NogoA and the chondroitin sulfate proteoglycans8–10.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]
PTEN and SOCS3 inhibition induce axonal sprouting in multiple adult CNS systems, including optic nerve and spinal cord injury.
“PTEN and SOCS3 inhibition induce axonal sprouting in multiple adult CNS systems, including optic nerve and spinal cord injury8,35.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]
Axonal sprouting in the adult occurs in a limited manner after stroke, optic nerve lesions, spinal cord injury and in models of neurodegenerative diseases.
“Axonal sprouting in the adult occurs in a limited manner after stroke, optic nerve lesions, spinal cord injury and in models of neurodegenerative diseases8,9.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]
PTEN inhibition potentiates axonal sprouting in optic nerve injury and spinal cord injury, through induction of PI3kinase signaling and activation of mTOR.
“PTEN inhibition potentiates axonal sprouting in optic nerve injury and spinal cord injury, through induction of PI3kinase signaling and activation of mTOR.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]

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Authors: Liu, K., Tedeschi, A., Park, K. K., & He, Z.
Affiliations: Harvard University (US)
ORCID: Liu, Kai
Tedeschi, Andrea
Park, Kevin Kyungsuk
He, Zhigang
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2011-07-21
Volume: 34
Issue: 1
Pages: 131-152
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev-neuro-061010-113723
OpenAlex: W2141003407
Cited by: 458
References: 151
Citations by year: 2026: 15 · 2025: 18 · 2024: 30 · 2023: 30 · 2022: 15 · 2021: 28 · 2020: 26 · 2019: 31 · 2018: 35 · 2017: 33 · 2016: 52 · 2015: 36 · 2014: 33 · 2013: 30 · 2012: 40
FWCI: 3.29
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: axon regeneration, central nervous system injury, functional recovery
MeSH terms: Cyclic AMP, Animals, Axons, Axonal Transport, Central Nervous System Diseases, Humans, Inflammation, Models, Neurological, Nerve Regeneration, Neurons, Cytokines, Suppressor of Cytokine Signaling Proteins

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Neuronal Intrinsic Mechanisms of Axon Regeneration

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