The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent
Open accessAbstract
Burn wounds are often complicated by bacterial infection, contributing to morbidity and mortality. Agents commonly used to treat burn wound infection are limited by toxicity, incomplete microbial coverage, inadequate penetration, and rising resistance. Curcumin is a naturally derived substance with innate antimicrobial and wound healing properties. Acting by multiple mechanisms, curcumin is less likely than current antibiotics to select for resistant bacteria. Curcumin's poor aqueous solubility and rapid degradation profile hinder usage; nanoparticle encapsulation overcomes this pitfall and enables extended topical delivery of curcumin. In this study, we synthesized and characterized curcumin nanoparticles (curc-np), which inhibited in vitro growth of methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa in dose-dependent fashion, and inhibited MRSA growth and enhanced wound healing in an in vivo murine wound model. Curc-np may represent a novel topical antimicrobial and wound healing adjuvant for infected burn wounds and other cutaneous injuries.
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Cites
Microbial colonization of large wounds
Vindenes, H., & Bjerknes, R. (1995) · Burns · doi:10.1016/0305-4179(95)00047-f · Cited by 181
Cited by
Wu, F., Misra, M., & Mohanty, A. K. (2021) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2021.101395 · Cited by 909
Alginate hydrogel dressings for advanced wound management
Zhang, M., & Zhao, X. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.311 · Cited by 616
Nanomaterials for Wound Healing and Infection Control
Mihai, M. M., Dima, M. B., Dima, B., & Holban, A. M. (2019) · Materials · doi:10.3390/ma12132176 · Cited by 448
Anti-infective Properties of the Golden Spice Curcumin
Praditya, D., Kirchhoff, L., Brüning, J., Rachmawati, H., Steinmann, J., & Steinmann, E. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00912 · Cited by 373
Xi, Y., Ge, J., Wang, M., Chen, M., Niu, W., Cheng, W., Xue, Y., Lin, C., & Lei, B. (2020) · ACS Nano · doi:10.1021/acsnano.9b07173 · Cited by 346
Metadata
- Authors
- Krausz, A. E., Adler, B. L., Cabral, V., Navati, M., Doerner, J., Charafeddine, R. A., Chandra, D., Liang, H., Gunther, L., Clendaniel, A., Harper, S., Friedman, J. M., Nosanchuk, J. D., & Friedman, A. J.
- Venue
- Nanomedicine: Nanotechnology, Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 11
- Issue
- 1
- Pages
- 195-206
- ISSN
- 1549-9634 (ISSN-L)
- OpenAlex
- W2124865710
- Cited by
- 515
- References
- 1
- FWCI
- 12.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Krausz, A. E., Adler, B. L., Cabral, V., Navati, M., Doerner, J., Charafeddine, R. A., Chandra, D., Liang, H., Gunther, L., Clendaniel, A., Harper, S., Friedman, J. M., Nosanchuk, J. D., & Friedman, A. J. (2015). Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. Nanomedicine: Nanotechnology, Biology and Medicine. https://doi.org/10.1016/j.nano.2014.09.004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
