The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Biodegradable hydrogel with thermo-response and hemostatic effect for photothermal enhanced anti-infective therapy
Abstract
Abstract Massive bleeding and infectious complication remain the leading cause of worldwide trauma deaths. To tackle this issue, a platelet-inspired degradable antibacterial hydrogel (Gel/PP-TA-Ag) is synthesized based on gelatin methacrylate (GelMA), tannic acid (TA), polyphosphate (PolyP) and gallic acid functionalized silver nanoparticles (Ag NPs) via a facile photopolymerization process. Accompanied by the degradation of the hydrogel, the released PolyP can activate the coagulation pathway, resulting in a better hemostatic effect than commercial gauze in the mice-bleeding model. Simultaneously, benefiting from hyperthermia originated from Ag NPs and photothermal accelerated release of TA and Ag+, 97.57% of methicillin-resistant Staphylococcus aureus (MRSA) and 95.99% of E. coli are eliminated in vitro. Moreover, in vivo experiments reveal that 91.76% of MRSA in wounds is removed, and the wound healing is effectively improved with more angiogenesis and collagen deposition. The level of inflammation in the wounds is also significantly reduced. As a result, Gel/PP-TA-Ag hydrogel possesses great potential in achieving satisfactory efficacy in infected wound healing.
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Cites
Resistance of Candida to azoles and echinocandins worldwide
Pristov, K. E., & Ghannoum, M. A. (2019) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2019.03.028 · Cited by 706
Cited by
Wound Dressing: From Nanomaterials to Diagnostic Dressings and Healing Evaluations
Zeng, Q., Qi, X., Shi, G., Zhang, M., & Haick, H. (2022) · ACS Nano · doi:10.1021/acsnano.1c08411 · Cited by 532
Cheng, S., Wang, H., Pan, X., Zhang, C., Zhang, K., Chen, Z., Dong, W., Xie, A., & Qi, X. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c25014 · Cited by 386
Engineered Hemostatic Biomaterials for Sealing Wounds
Montazerian, H., Davoodi, E., Baidya, A., Baghdasarian, S., Sarikhani, E., Meyer, C. E., Haghniaz, R., Badv, M., Annabi, N., Khademhosseini, A., et al. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c01015 · Cited by 291
Guo, H., Huang, S., Xu, A., & Xue, W. (2022) · Chemistry of Materials · doi:10.1021/acs.chemmater.1c03944 · Cited by 204
Emerging materials for hemostasis
Li, X.-F., Lu, P., Jia, H.-R., Li, G., Zhu, B., Wang, X., & Wu, F.-G. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214823 · Cited by 164
Metadata
- Authors
- Cao, C., Yang, N., Zhao, Y., Yang, D., Hu, Y., Yang, D., Song, X., Wang, W., & Dong, X.
- Venue
- Nano Today
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 39
- Pages
- 101165
- ISSN
- 1748-0132 (ISSN-L)
- OpenAlex
- W3159247390
- Cited by
- 205
- References
- 1
- FWCI
- 17.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cao, C., Yang, N., Zhao, Y., Yang, D., Hu, Y., Yang, D., Song, X., Wang, W., & Dong, X. (2021). Biodegradable hydrogel with thermo-response and hemostatic effect for photothermal enhanced anti-infective therapy. Nano Today. https://doi.org/10.1016/j.nantod.2021.101165
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