The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Dendritic Hydrogels with Robust Inherent Antibacterial Properties for Promoting Bacteria-Infected Wound Healing
Abstract
Bacterial infections are a common problem associated with wound treatment that imposes a significant burden on healthcare systems and patients. As a result, healthcare providers urgently need new treatment strategies to protect people. Hydrogel biomaterials with inherent antimicrobial properties offer an attractive and viable solution to this issue. Here, for the first time, we have developed a new efficient synthetic strategy to prepare cationic hydrogels (PHCI) with intrinsically efficient antimicrobial properties by chemically cross-linking trans -1,4-cyclohexanediamine with 1,3-dibromo-2-propanol using a condensation reaction without the use of toxic cross-linking agents. As expected, the prepared PHCI hydrogel possessed an inherent antibacterial ability that can adsorb and kill Staphylococcus aureus and Escherichia coli electrostatically. Notably, in vivo experiments on normal and diabetic rat models confirmed that the PHCI hydrogel can quickly stop bleeding, efficiently kill bacteria, promote the conversion of macrophages from the proinflammatory M1 phenotype to the repaired M2 phenotype, and accelerate collagen deposition and blood vessel formation, thereby achieving rapid wound healing. Overall, this work presents an effective antibacterial dressing that might provide a facile but effective approach for clinical wound management.
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Cites
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research
Turner, N. A., Sharma-Kuinkel, B. K., Maskarinec, S. A., Eichenberger, E. M., Shah, P. P., Carugati, M., Holland, T. L., & Fowler, V. G. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0147-4 · Cited by 2,051
Liang, Y., Li, Z., Huang, Y., Yu, R., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c00204 · Cited by 1,083
Drug delivery systems and materials for wound healing applications
Saghazadeh, S., Rinoldi, C., Schot, M., Kashaf, S. S., Sharifi, F., Jalilian, E., Nuutila, K., Giatsidis, G., Mostafalu, P., Derakhshandeh, H., et al. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.04.008 · Cited by 842
Antibacterial Carbon‐Based Nanomaterials
Xin, Q., Shah, H., Nawaz, A., Xie, W., Akram, M. Z., Batool, A., Tian, L., Jan, S. U., Boddula, R., Guo, B., et al. (2019) · Advanced Materials · doi:10.1002/adma.201804838 · Cited by 814
Fan, Z., Liu, B., Wang, J., Zhang, S., Lin, Q., Gong, P., Ma, L., & Yang, S. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201304202 · Cited by 812
Wound healing and treating wounds
Powers, J. G., Higham, C., Broussard, K., & Phillips, T. J. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.08.070 · Cited by 753
Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs
Yu, J., Wang, J., Zhang, Y., Chen, G., Mao, W., Ye, Y., Kahkoska, A. R., Buse, J. B., Langer, R., & Gu, Z. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0508-y · Cited by 604
Zhu, Y., Zhang, J., Song, J., Yang, J., Du, Z., Zhao, W., Guo, H., Wen, C., Li, Q., Sui, X., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201905493 · Cited by 538
Cited by
Hydrogels and Nanogels: Pioneering the Future of Advanced Drug Delivery Systems
Delgado-Pujol, E. J., Martínez, G., Casado-Jurado, D., Vázquez, J., León-Barberena, J., Rodríguez-Lucena, D., Torres, Y., Alcudia, A., & Begines, B. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17020215 · Cited by 216
Chen, Y., Zhang, Y., Chang, L., Sun, W., Duan, W., & Qin, J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125644 · Cited by 35
Metadata
- Authors
- Cheng, S., Wang, H., Pan, X., Zhang, C., Zhang, K., Chen, Z., Dong, W., Xie, A., & Qi, X.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-02-23
- Volume
- 14
- Issue
- 9
- Pages
- 11144-11155
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W4212817653
- Cited by
- 386
- References
- 39
- FWCI
- 25.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cheng, S., Wang, H., Pan, X., Zhang, C., Zhang, K., Chen, Z., Dong, W., Xie, A., & Qi, X. (2022). Dendritic Hydrogels with Robust Inherent Antibacterial Properties for Promoting Bacteria-Infected Wound Healing. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.1c25014
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