Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders

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Environmental enrichment-inspired pharmacological tools for the treatment of addiction

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Environment‐dependent behavioral traits and experiential factors shape addiction vulnerability

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A three-dimensional habitat for C. elegans environmental enrichment

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Postoperative Cognitive Dysfunction and the Protective Effects of Enriched Environment: A Systematic Review

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Physiological effects of enriched environment exposure and LTP induction in the hippocampus in vivo do not transfer faithfully to in vitro slicesPreprint

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Cognitive interventions in Alzheimer's and Parkinson's diseases: emerging mechanisms and role of imaging

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The effects of isolated and enriched housing conditions on baseline and drug-induced behavioural responses in the male rat

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Integrating mitochondriomics in children's environmental health

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The Directive 2010/63/EU on animal experimentation may skew the conclusions of pharmacological and behavioural studies

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Enriched Environment and Effects on Neuropathic Pain: Experimental Findings and Mechanisms

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Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice

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Antidepressive behaviors induced by enriched environment might be modulated by glucocorticoid levels

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Environmental eustress promotes liver regeneration through the sympathetic regulation of type 1 innate lymphoid cells to increase IL-22 in mice

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Alzheimer's Disease: The Quest to Understand Complexity

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Altered emotional and motivational processing in the transgenic rat model for Huntington’s disease

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Effects of environmental manipulations in genetically targeted animal models of affective disorders

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Automated quantitative analysis to assess motor function in different rat models of impaired coordination and ataxia

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Corticosterone levels and behavioral changes induced by simultaneous exposure to chronic social stress and enriched environments in NMRI male mice

Mesa‐Gresa, P., Ramos‐Campos, M., & Redolat, R. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.02.027 · Cited by 32

Antidepressant and Proneurogenic Influence of Environmental Enrichment in Mice: Protective Effects vs Recovery

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Early exposure to environmental enrichment modulates the effects of prenatal ethanol exposure upon opioid gene expression and adolescent ethanol intake

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Environmental enrichment for stroke and other non-progressive brain injury

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Behavior of Rodents with an Emphasis on Enrichment

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Lifelong and carry-over effects of early captive exposure in a recovery program for Atlantic salmon (Salmo salar)

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Early Social Enrichment Improves Social Motivation and Skills in a Monogenic Mouse Model of Autism, theOprm1−/−Mouse

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Behavioral effects of combined environmental enrichment and chronic nicotine administration in male NMRI mice

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Theoretical and practical considerations behind the use of laboratory animals for the study of Tourette syndrome

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Non-pharmacological Approaches to Cognitive Enhancement

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The Snark was a Boojum - reloaded

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Environmentally enriched pigs have transcriptional profiles consistent with neuroprotective effects and reduced microglial activity

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Effect of environmental enrichment on physical and psychological dependence signs and voluntary morphine consumption in morphine-dependent and morphine-withdrawn rats

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Pre and post-injury environmental enrichment effects functional recovery following medial frontal cortical contusion injury in rats

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Parkinson’s disease in Jordan: Barriers and motivators to exercise

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Environmental enrichment has minimal effects on behavior in the Shank3 complete knockout model of autism spectrum disorder

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Enriched environment attenuates nicotine self-administration and induces changes in ΔFosB expression in the rat prefrontal cortex and nucleus accumbens

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Early environmental enrichment prevents cognitive impairments and developing addictive behaviours in a mouse model of prenatal psychological and physical stress

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Early postnatal handling and environmental enrichment improve the behavioral responses of 17-month-old 3xTg-AD and non-transgenic mice in the Forced Swim Test in a gender-dependent manner

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Evaluation of study design variables and their impact on food-maintained operant responding in mice

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Environmental Enrichment Facilitates Long-Term Potentiation in Embryonic Striatal Grafts

Mazzocchi‐Jones, D., Döbrössy, M. D., & Dunnett, S. B. (2011) · Neurorehabilitation and neural repair · doi:10.1177/1545968311402090 · Cited by 21

Environmental enrichment alters structural plasticity of the adolescent brain but does not remediate the effects of prenatal nicotine exposure

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Neighborhood Perceptions Are Associated With Tobacco Dependence Among African American Smokers

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Enriched environment remodels the central immune environment and improves the prognosis of acute ischemic stroke in elderly mice with chronic ischemia

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Physical exercise is required for environmental enrichment to offset the quantitative effects of dark‐rearing on the S‐100β astrocytic density in the rat visual cortex

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Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment

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The differential effects of brief environmental enrichment following social isolation in rats

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Experimental manipulations blunt time-induced changes in brain monoamine levels and completely reverse stress, but not Pb+/−stress-related modifications to these trajectories

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Genomic modules and intramodular network concordance in susceptible and resilient male mice across models of stress

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Droplets of black bile? Development of vulnerability and resilience to depression in young age

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The effects of acrobatic exercise on brain plasticity: a systematic review of animal studies

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Enriched Environment Rearing from Birth Reduced Anxiety, Improved Learning and Memory, and Promoted Social Interactions in Adult Male Mice

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An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation

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Animal Models of Human Anxiety Disorders: Reappraisal From a Developmental Psychopathology Vantage Point

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Effect of resveratrol and environmental enrichment on biomarkers of oxidative stress in young healthy mice

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Leptin Promotes Glioblastoma

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Noise exposure of immature rats can induce different age-dependent extra-auditory alterations that can be partially restored by rearing animals in an enriched environment

Molina, S. J., Capani, F., & Guelman, L. R. (2016) · Brain Research · doi:10.1016/j.brainres.2016.01.050 · Cited by 17

Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations

Molina, S. J., Buján, G. E., Gonzalez, M. R., Capani, F., Gómez‐Casati, M. E., & Guelman, L. R. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00182 · Cited by 16

Staging Perspectives in Neurodevelopmental Aspects of Neuropsychiatry: Agents, Phases and Ages at Expression

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Neuroprotective effects of enriched environment in MPTP-treated SAMP8 mice

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Interaction of genotype and environment: effect of strain and housing conditions on cognitive behavior in rodent models of schizophrenia

Turner, K. M., & Burne, T. H. J. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00097 · Cited by 16

Environmental stimulation influence the cognition of developing mice by inducing changes in oxidative and apoptosis status

Cheng, L., Wang, S., Jia, N., Xie, M., & Liao, X. (2012) · Brain and Development · doi:10.1016/j.braindev.2012.11.015 · Cited by 16

Constraint-induced movement therapy as a paradigm of translational research in neurorehabilitation: Reviews and prospects.

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Environmental Enrichment Improves Behavioral Abnormalities in a Mouse Model of Angelman Syndrome

Jamal, I., Kumar, V., Vatsa, N., Singh, B. K., Shekhar, S., Sharma, A., & Jana, N. R. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0080-3 · Cited by 16

Abstinence environment contributes to age differences in reinstatement of cocaine seeking between adolescent and adult male rats

Li, C., & Frantz, K. J. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.06.003 · Cited by 15

Duration of Environmental Enrichment Determines Astrocyte Number and Cervical Lymph Node T Lymphocyte Proportions but Not the Microglial Number in Middle-Aged C57BL/6 Mice

Singhal, G., Morgan, J., Jawahar, M. C., Corrigan, F., Jaehne, E. J., Toben, C. G., Manavis, J., Hannan, A. J., & Baune, B. T. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00057 · Cited by 16

Noise‐induced hippocampal oxidative imbalance and aminoacidergic neurotransmitters alterations in developing male rats: Influence of enriched environment during adolescence

Molina, S. J., Buján, G. E., & Guelman, L. R. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22806 · Cited by 15

miR-128 as a Regulator of Synaptic Properties in 5xFAD Mice Hippocampal Neurons

Shvarts-Serebro, I., Sheinin, A., Gottfried, I., Adler, L., Schottlender, N., Ashery, U., & Barak, B. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01862-2 · Cited by 15

Prolonged exposure to a music-enriched environment mitigates acute noise-induced inflammation and apoptosis in the chicken spleen by modulating the Keap-1/Nrf2 and NF-κB pathways

Wang, H., Wang, Y., Chai, Y., Zhang, H., Chang, Q., Li, J., Zhang, R., & Bao, J. (2024) · Poultry Science · doi:10.1016/j.psj.2024.104100 · Cited by 14

Peripubertal exposure to environmental enrichment prevents schizophrenia-like behaviors in the SHR strain animal model

Santos, C. M., Peres, F. F., Diana, M. C., Justi, V., Suiama, M. A., Santana, M. G., & Abílio, V. C. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.06.006 · Cited by 14

Enriched environment ameliorates propagation of tau pathology and improves cognition in rat model of tauopathy

Mate, V., Smolek, T., Kazmerova, Z., Jadhav, S., Brezováková, V., Jurkanin, B., Uhrinova, I., Basheer, N., Žilka, N., Katina, S., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.935973 · Cited by 15

miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy

Xylaki, M., Paiva, I., Al‐Azzani, M., Gerhardt, E., Jain, G., Islam, R., Vasili, E., Wassouf, Z., Schulze-Hentrich, J. M., Fischer, A., et al. (2023) · Journal of Parkinson s Disease · doi:10.3233/jpd-225055 · Cited by 13

Differential effects of MDMA and cocaine on inhibitory avoidance and object recognition tests in rodents

García-Pardo, M. P., Ortí, J. E. D. L. R., & Calpe, M. A. A. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.10.013 · Cited by 15

The short-term improvements of enriched environment in behaviors and pathological changes of APP/PS1 mice via regulating cytokines

Zhang, Y., Wang, G., Wang, L., Zhao, J., Huang, R., & Xiong, Q. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2018.1463944 · Cited by 13

Exposure to sucrose during periods of withdrawal does not reduce cocaine-seeking behavior in rats

Nicolas, C., Lafay‐Chebassier, C., & Solinas, M. (2016) · Scientific Reports · doi:10.1038/srep23272 · Cited by 13

Response, use and habituation to a mouse house in C57BL/6J and BALB/c mice

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The systemic effects of the enriched environment on the conditioned fear reaction

Grigoryan, G. A. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1227575 · Cited by 12

Both pre- and post-lesion experiential therapy is beneficial in 6-hydroxydopamine dopamine-depleted female rats

Jadavji, N. M., & Metz, G. A. S. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.054 · Cited by 12

Environmental enrichment ameliorates phencyclidine-induced cognitive deficits

Saland, S. K., & Rodefer, J. S. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.02.014 · Cited by 12

PDE5 Inhibition Improves Object Memory in Standard Housed Rats but Not in Rats Housed in an Enriched Environment: Implications for Memory Models?

Akkerman, S., Prickaerts, J., Bruder, A. K., Wolfs, K. H. M., Vry, J. D., Vanmierlo, T., & Blokland, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111692 · Cited by 12

A New Random Positioning Machine Modification Applied for Microgravity Simulation in Laboratory Experiments with Rats

Yotov, V. V., Marovska, J., Turiyski, V. I., & Ivanov, S. I. (2022) · Inventions · doi:10.3390/inventions7030085 · Cited by 11

The effects of virtual reality environmental enrichments on craving to food in healthy volunteers

Benvegnù, G., Piva, A., Cadorin, C., Mannari, V., Girondini, M., Federico, A., Tamburin, S., & Chiamulera, C. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06462-z · Cited by 11

Alternation in dopamine D 2 -like and metabotropic glutamate type 5 receptor density caused by differing housing conditions during abstinence from cocaine self-administration in rats

Frankowska, M., Miszkiel, J., Pomierny-Chamioło, L., Pomierny, B., Giannotti, G., Suder, A., & Filip, M. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881118821113 · Cited by 12

The impact of sensory and motor enrichment on the epigenetic control of steroidogenic-related genes in rat hippocampus

Rossetti, M. F., Schumacher, R., Lazzarino, G. P., Gómez, A. L., Varayoud, J., & Ramos, J. G. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.01.025 · Cited by 12

Effects of handling on the behavioural phenotype of the neuregulin 1 type III transgenic mouse model for schizophrenia

Guerra, S., Chesworth, R., Weickert, C. S., & Karl, T. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113166 · Cited by 11

Which form of environmental enrichment is most effective in rodent models of autism?

Caires, C. R. S., & Bossolani-Martins, A. L. (2023) · Behavioural Processes · doi:10.1016/j.beproc.2023.104915 · Cited by 10

Environmental enrichment promotes adaptive responding during tests of behavioral regulation in male heterogeneous stock rats

Ishiwari, K., King, C. P., Martin, C. D., Tripi, J. A., George, A., Lamparelli, A. C., Chitre, A. S., Polesskaya, O., Richards, J. B., Woods, L. S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-53943-y · Cited by 8

“Mens Sana in Corpore Sano”: The Emerging Link of Motor Reserve with Motor and Cognitive Abilities and Compensatory Brain Networks in SCA2 Patients

Siciliano, L., Olivito, G., Urbini, N., Silveri, M. C., & Leggio, M. G. (2022) · Biomedicines · doi:10.3390/biomedicines10092166 · Cited by 10

Methodological shortcomings of preclinical research on chemotherapy-induced cognitive impairment

Salazar, V. A. O., & D’Hooge, R. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105198 · Cited by 10

Environmental enrichment rescues memory in mice deficient for the polysialytransferase ST8SiaIV

Zerwas, M., Trouche, S. G., Richetin, K., Escudé, T., Halley, H., Gerardy‐Schahn, R., Verret, L., & Rampon, C. (2015) · Brain Structure and Function · doi:10.1007/s00429-015-0991-1 · Cited by 10

Effects of early noise exposure on hippocampal-dependent behaviors during adolescence in male rats: influence of different housing conditions

Molina, S. J., Lietti, Á. E., Carreira, C. S., Buján, G. E., & Guelman, L. R. (2021) · Animal Cognition · doi:10.1007/s10071-021-01540-1 · Cited by 10

Scoping review on environmental enrichment: Are critical periods and sex differences adequately studied?

Torres-Reverón, A., & Dow-Edwards, D. L. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173420 · Cited by 10

Simple shelter-style environmental enrichment alters behavior in mice

Coke-Murphy, C., Buendia, M. A., Saborido, T. P., & Stanwood, G. D. (2014) · Translational Neuroscience · doi:10.2478/s13380-014-0228-4 · Cited by 9

Rearing conditions differently affect the motor performance and cerebellar morphology of prenatally stressed juvenile rats

Ulupınar, E., Erol, K., Ay, H., & Yücel, F. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.10.003 · Cited by 9

Translating preclinical environmental enrichment studies for the treatment of autism and other brain disorders: Comment on Woo and Leon (2013).

Hill‐Yardin, E. L., & Hannan, A. J. (2013) · Behavioral Neuroscience · doi:10.1037/a0033319 · Cited by 9

Enriched environment elevates expression of growth associated protein-43 in the substantia nigra of SAMP8 mice

Yuan, Z.-Y., Yang, J., Ma, X., Wang, Y.-Y., & Wang, M. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.239447 · Cited by 9

Sprouting of Nervous Fibers and Upregulation of C‐X‐C Chemokine Receptor Type 4 Expression in Hippocampal Formation of Rats with Enhanced Spatial Learning and Memory

Bao-gui, S., Pan, S., He, X., Peng, L., & Liang, Y. (2011) · The Anatomical Record · doi:10.1002/ar.21518 · Cited by 9

An epigenetic mechanism of social isolation stress in adolescent female mice

Li, P., & Yan, Z. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100601 · Cited by 8

The Relevance of Operant Behavior in Conceptualizing the Psychological Well-Being of Captive Animals

Rasmussen, E. B., Newland, M. C., & Hemmelman, E. (2020) · Perspectives on Behavior Science · doi:10.1007/s40614-020-00259-7 · Cited by 8

Social environment enrichment alleviates anxiety-like behavior in mice: Involvement of the dopamine system

Wang, Q., Wang, Y., Tian, Y., Li, Y., Han, J., Tai, F., & Jia, R. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114687 · Cited by 10

From Epigenetic Associations to Biological and Psychosocial Explanations in Mental Health

Renzi, C., Provençal, N., Bassil, K. C., Evers, K., Kihlbom, U., Radford, E. J., Koupil, I., Mueller-Myhsok, B., HANSSON, M. G., & Rutten, B. P. F. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.04.011 · Cited by 8

Anxiolytic and panicolytic-like effects of environmental enrichment seem to be modulated by serotonin neurons located in the dorsal subnucleus of the dorsal raphe

Lopes, D. A., Souza, T. M. O., de Andrade, J. S., Silva, M. S. C. F., Antunes, H. K. M., Sueur, L. D. P. L., Céspedes, I. C., & Viana, M. D. B. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.06.012 · Cited by 8

Animal models of developmental dyslexia: Where we are and what we are missing

Lampis, V., Ventura, R., Segni, M. D., Marino, C., D'Amato, F. R., & Mascheretti, S. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.022 · Cited by 9

Preventive Effects of an Enriched Environment on Rodent Psychiatric Disorder Models

Takuma, K., Ago, Y., & Matsuda, T. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11r07cp · Cited by 37

Enriched environments, experience-dependent plasticity and disorders of the nervous system

Nithianantharajah, J., & Hannan, A. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1970 · Cited by 1,771

Environmental enrichment: Evidence for an unexpected therapeutic influence

Kotloski, R. J., & Sutula, T. P. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.11.012 · Cited by 54

Enviromimetics: exploring gene environment interactions to identify therapeutic targets for brain disorders

McOmish, C. E., & Hannan, A. J. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.7.899 · Cited by 66

Review: Environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience‐dependent plasticity

Hannan, A. J. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12102 · Cited by 240