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Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders

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Laviola, Giovanni, Hannan, Anthony J., Macrì, Simone, Solinas, Marcello, Jaber, Mohamed·2008·Neurobiology of Disease

DOI 10.1016/j.nbd.2008.05.001

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Abstract

Environmental stimulation throughout development adjusts the neurobehavioral systems involved in learning, memory and defensive responses. Environment-mediated phenotypic plasticity can be considered from two different, yet complementary, viewpoints. On one hand, the possibility that environmental interventions protect against the effects of genetic and/or acquired vulnerabilities, offers unprecedented avenues towards the elaboration and refinement of therapeutic strategies. On the other hand, an accurate understanding of the adaptive mechanisms regulating the interaction between an experimental subject and its environment may substantially benefit the quality of experimental data. Here we review experimental evidence showing that enriched environment can be beneficial in several psychiatric and neurodegenerative disorders implicating the monoamine systems where it can (i) compensate for impairments in animal models of schizophrenia, Huntington's, and Parkinson's diseases; (ii) increase resistance to the addictive properties of psychostimulant drugs; (iii) level-out the consequences of prenatal stress in animal models of depression. Additionally we discuss why some of the effects of environmental enrichment question the validity of current animal models of mental disorders.

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Authors: Laviola, G., Hannan, A. J., Macrì, S., Solinas, M., & Jaber, M.
Affiliations: The University of Melbourne (AU)
Centre National de la Recherche Scientifique (FR)
Corresponding author: Jaber, Mohamed
ORCID: Hannan, Anthony J.
Solinas, Marcello
Jaber, Mohamed
Venue: Neurobiology of Disease
Publisher: Elsevier BV
Published: 2008-08
Volume: 31
Issue: 2
Pages: 159-168
ISSN: 0969-9961 (ISSN-L)
DOI: 10.1016/j.nbd.2008.05.001
OpenAlex: W2050671544
Cited by: 300
References: 117
Citations by year: 2026: 7 · 2025: 7 · 2024: 4 · 2023: 17 · 2022: 15 · 2021: 15 · 2020: 12 · 2019: 16 · 2018: 16 · 2017: 9 · 2016: 19 · 2015: 21 · 2014: 20 · 2013: 23 · 2012: 19
FWCI: 2.04
Type: journal article
Language: en
Open access: green
doaj.org
Licence: cc-by-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Disease (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Alliance for Research on Schizophrenia and Depression
Fondation pour la Recherche Médicale
Ministero della Salute
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: environmental enrichment, neurodegenerative diseases, mental illness, schizophrenia, Huntington's disease, Parkinson's disease, monoaminergic systems, stimulant use disorder, prenatal stress, depression, phenotypic plasticity, animal models of psychiatric disorders, model validity
MeSH terms: Animals, Mental Disorders, Brain, Brain Chemistry, Disease Models, Animal, Environment Design, Humans, Stress, Psychological, Biogenic Monoamines, Neurodegenerative Diseases, Substance-Related Disorders

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Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders

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