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Cited by 358

The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.

Neurophysiology of dystonia: The role of inhibition

Open access
Hallett, Mark·2011·Neurobiology of Disease

Abstract

The pathophysiology of dystonia has been best studied in patients with focal hand dystonia. A loss of inhibitory function has been demonstrated at spinal, brainstem and cortical levels. Many cortical circuits seem to be involved. One consequence of the loss of inhibition is a failure of surround inhibition, and this appears to directly lead to overflow and unwanted muscle spasms. There are mild sensory abnormalities and deficits in sensorimotor integration; these also might be explained by a loss of inhibition. Increasing inhibition may be therapeutic. A possible hypothesis is that there is a genetic loss of inhibitory interneurons in dystonia and that this deficit is a substrate on which other factors can act to produce dystonia.

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Metadata

Authors
Hallett, M.
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2011-05
Volume
42
Issue
2
Pages
177-184
ISSN
0969-9961 (ISSN-L)
OpenAlex
W1968263341
Cited by
358
References
97
FWCI
13.02
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Neurophysiology of dystonia: The role of inhibition. https://app.cochat.ai/papers/10.1016/j.nbd.2010.08.025
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Hallett, M. (2011). Neurophysiology of dystonia: The role of inhibition. Neurobiology of Disease. https://doi.org/10.1016/j.nbd.2010.08.025

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.