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Cited by 178

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Altered resting state functional brain network topology in chemotherapy-treated breast cancer survivors

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Bruno, Jennifer, Hosseini, S.M. Hadi, Kesler, Shelli·2012·Neurobiology of Disease
DOI 10.1016/j.nbd.2012.07.009
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Abstract

Many women with breast cancer, especially those treated with chemotherapy, experience cognitive decline due in part to neurotoxic brain injury. Recent neuroimaging studies suggest widespread brain structural abnormalities pointing to disruption of large-scale brain networks. We applied resting state functional magnetic resonance imaging and graph theoretical analysis to examine the connectome in breast cancer survivors treated with chemotherapy relative to healthy comparison women. Compared to healthy females, the breast cancer group displayed altered global brain network organization characterized by significantly decreased global clustering as well as disrupted regional network characteristics in frontal, striatal and temporal areas. Breast cancer survivors also showed significantly increased self-report of executive function and memory difficulties compared to healthy females. These results suggest that topological organization of both global and regional brain network properties may be disrupted following breast cancer and chemotherapy. This pattern of altered network organization is believed to result in reduced efficiency of parallel information transfer. This is the first report of alterations in large-scale functional brain networks in this population and contributes novel information regarding the neurobiologic mechanisms underlying breast cancer-related cognitive impairment.

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Metadata

Authors
Bruno, J., Hosseini, S. M. H., & Kesler, S.
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2012-12
Volume
48
Issue
3
Pages
329-338
ISSN
0969-9961 (ISSN-L)
DOI
10.1016/j.nbd.2012.07.009
OpenAlex
W2073940256
Cited by
178
References
11
FWCI
5.83
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Altered resting state functional brain network topology in chemotherapy-treated breast cancer survivors. https://app.cochat.ai/papers/10.1016/j.nbd.2012.07.009
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Bruno, J., Hosseini, S. M. H., & Kesler, S. (2012). Altered resting state functional brain network topology in chemotherapy-treated breast cancer survivors. Neurobiology of Disease. https://doi.org/10.1016/j.nbd.2012.07.009

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.