The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Vagus nerve stimulation during rehabilitative training improves forelimb strength following ischemic stroke
Open accessAbstract
Upper limb impairment is a common debilitating consequence of ischemic stroke. Physical rehabilitation after stroke enhances neuroplasticity and improves limb function, but does not typically restore normal movement. We have recently developed a novel method that uses vagus nerve stimulation (VNS) paired with forelimb movements to drive specific, long-lasting map plasticity in rat primary motor cortex. Here we report that VNS paired with rehabilitative training can enhance recovery of forelimb force generation following infarction of primary motor cortex in rats. Quantitative measures of forelimb function returned to pre-lesion levels when VNS was delivered during rehab training. Intensive rehab training without VNS failed to restore function back to pre-lesion levels. Animals that received VNS during rehab improved twice as much as rats that received the same rehabilitation without VNS. VNS delivered during physical rehabilitation represents a novel method that may provide long-lasting benefits towards stroke recovery.
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Cites
Plasticity during stroke recovery: from synapse to behaviour
Murphy, T. H., & Corbett, D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2735 · Cited by 1,938
The impact of physical therapy on functional outcomes after stroke: what's the evidence?
Van Peppen, R. P., Kwakkel, G., Wood-Dauphinee, S., Hendriks, H. J., Van der Wees, P. J., & Dekker, J. (2004) · Clinical Rehabilitation · doi:10.1191/0269215504cr843oa · Cited by 942
Modulation of visual cortical plasticity by acetylcholine and noradrenaline
Bear, M. F., & Singer, W. (1986) · Nature · doi:10.1038/320172a0 · Cited by 858
Vagus-nerve stimulation for the treatment of epilepsy
Ben-Menachem, E. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00220-x · Cited by 560
Vagus nerve stimulation: a new tool for brain research and therapy
George, M. S., Sackeim, H. A., Rush, A. J., Marangell, L. B., Nahas, Z., Husain, M. M., Lisanby, S., Burt, T., Goldman, J., & Ballenger, J. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00308-x · Cited by 461
Neuromodulators control the polarity of spike-timing-dependent synaptic plasticity
Seol, G. H., Ziburkus, J., Huang, S., Song, L., Kim, I. T., Takamiya, K., Huganir, R. L., Lee, H.-K., & Kirkwood, A. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.013 · Cited by 429
Carmichael, S. T., Archibeque, I., Luke, L., Nolan, T., Momiy, J., & Li, S. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.01.004 · Cited by 421
Cited by
Hulsey, D. R., Riley, J. R., Loerwald, K. W., Rennaker, R. L., Kilgard, M. P., & Hays, S. A. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2016.12.005 · Cited by 313
Self-citationDawson, J., Pierce, D., Dixit, A., Kimberley, T. J., Robertson, M., Tarver, B., Hilmi, O., McLean, J., Forbes, K., Kilgard, M. P., et al. (2016) · Stroke · doi:10.1161/strokeaha.115.010477 · Cited by 300
Self-citationVagal nerve stimulation for treatment-resistant depression
Carreno, F. R., & Frazer, A. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0537-8 · Cited by 208
Noble, L. J., Gonzalez, I. J., Meruva, V. B., Callahan, K. A., Belfort, B. D., Ramanathan, K. R., Meyers, E., Kilgard, M. P., Rennaker, R. L., & McIntyre, C. K. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.191 · Cited by 121
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Metadata
- Authors
- Khodaparast, N., Hays, S. A., Sloan, A. M., Hulsey, D. R., Ruiz, A., Pantoja, M., Rennaker, R. L., & Kilgard, M. P.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 60
- Pages
- 80-88
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2020482688
- Cited by
- 158
- References
- 7
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Khodaparast, N., Hays, S. A., Sloan, A. M., Hulsey, D. R., Ruiz, A., Pantoja, M., Rennaker, R. L., & Kilgard, M. P. (2013). Vagus nerve stimulation during rehabilitative training improves forelimb strength following ischemic stroke. Neurobiology of Disease. https://doi.org/10.1016/j.nbd.2013.08.002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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