Neuromodulators control the polarity of spike-timing-dependent synaptic plasticity
Open accessAbstract
Near coincidental pre- and postsynaptic action potentials induce associative long-term potentiation (LTP) or long-term depression (LTD), depending on the order of their timing. Here, we show that in visual cortex the rules of this spike-timing-dependent plasticity are not rigid, but shaped by neuromodulator receptors coupled to adenylyl cyclase (AC) and phospholipase C (PLC) signaling cascades. Activation of the AC and PLC cascades results in phosphorylation of postsynaptic glutamate receptors at sites that serve as specific "tags" for LTP and LTD. As a consequence, the outcome (i.e., whether LTP or LTD) of a given pattern of pre- and postsynaptic firing depends not only on the order of the timing, but also on the relative activation of neuromodulator receptors coupled to AC and PLC. These findings indicate that cholinergic and adrenergic neuromodulation associated with the behavioral state of the animal can control the gating and the polarity of cortical plasticity.
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Spike-timing and noradrenaline-dependent LTP in the cortex preferentially recruit phosphorylated S845 GluA1-containing receptors.
“Spike-timing and noradrenaline-dependent LTP in the cortex, for example, will preferentially recruit phosphorylated S845 GluA1-containing receptors (Seol et al., 2007).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Seol et al., 2007
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- Authors
- Seol, G. H., Ziburkus, J., Huang, S., Song, L., Kim, I. T., Takamiya, K., Huganir, R. L., Lee, H.-K., & Kirkwood, A.
- Affiliations
- Johns Hopkins University (US)
- University of Maryland, College Park (US)
- Corresponding author
- Kirkwood, Alfredo
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 55
- Issue
- 6
- Pages
- 919-929
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2756178
- OpenAlex
- W2015144766
- Cited by
- 429
- References
- 1
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 14 · 2023: 28 · 2022: 14 · 2021: 24 · 2020: 10 · 2019: 23 · 2018: 35 · 2017: 27 · 2016: 18 · 2015: 20 · 2014: 21 · 2013: 29 · 2012: 27
- FWCI
- 10.62
- Type
- journal article
- Language
- en
- Update notices
- erratum (2007-11-21)
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2146 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (R01-EY014882, RO1 EY12124)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- spike-timing-dependent plasticity, long-term potentiation, long-term depression, neuromodulation, adenylyl cyclase signaling, phospholipase C signaling, cholinergic modulation, adrenergic modulation, visual cortex, synaptic plasticity, behavioral state
- MeSH terms
- Adenylyl Cyclases, Animals, Electrophysiology, Mice, Inbred C57BL, Neuronal Plasticity, Type C Phospholipases, Receptors, Adrenergic, beta, Serine, Synapses, Visual Cortex, Blotting, Western, Long-Term Potentiation, Pyramidal Cells, Receptors, AMPA, Neurotransmitter Agents, Patch-Clamp Techniques, Rats, Long-Evans, Receptor, Muscarinic M1, Mice, Rats
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